At a Glance
- Tasks: Develop innovative enzymes using computational and experimental techniques in a collaborative research environment.
- Company: Join the Manchester Institute of Biotechnology, a leader in enzyme engineering and biocatalysis.
- Benefits: Enjoy 29 days annual leave, pension contributions, and flexible working arrangements.
- Other info: We celebrate diversity and promote a supportive work-life balance.
- Why this job: Make a real impact on drug discovery while working with top researchers globally.
- Qualifications: PhD in Chemistry or related field; strong background in synthetic organic chemistry required.
The predicted salary is between 30000 - 40000 £ per year.
We seek to appoint an outstanding and ambitious early career scientist to a Research Associate Position in Enzyme Engineering and Biocatalysis. The aim of the research is to develop enzymes with new and valuable catalytic functions using a range of computational and experimental techniques. The post is tenable for 18 months from 1st July 2026.
Project & Collaborations
The successful candidate will work within Prof Buller's research team based in the Manchester Institute of Biotechnology (MIB), with close collaboration across Prof Anthony Green's group (MIB) and Prof David Baker's group at the Institute for Protein Design, University of Washington. The project, funded by the Bill & Melinda Gates Foundation, focuses on engineering pyridoxal‑phosphate‑dependent decarboxylative aldolases for the stereoselective synthesis of γ‑hydroxy non‑canonical amino acids and downstream 1,3‑amino alcohols of relevance to antitubercular drug discovery.
Qualifications & Experience
- PhD (or equivalent) in Chemistry or a closely related discipline.
- Strong synthetic organic chemistry background and demonstrated experience applying biocatalysis to stereoselective synthesis.
- Familiarity with heterologous protein expression in E. coli, synthesis of functionalised ketones, or high‑throughput screening is advantageous.
- Full training in directed evolution and protein engineering will be provided.
- Capability to work independently and collaborate effectively with academic partners across institutions; excellent communication and organisational skills are essential.
Equality & Diversity
The Department of Chemistry is strongly committed to promoting equality and diversity, including the Athena SWAN Charter for gender equality in higher education. The Department holds a Silver Award which recognises good practice in relation to gender; including flexible working arrangements, family‑friendly policies, and support to allow staff to achieve a good work‑life balance. We particularly welcome applications from women for this post. Appointments will always be made on merit.
Benefits
- Generous employer contribution pension
- 29 days annual leave plus bank holidays, along with Christmas closure
- Ride to work and EV car scheme available
For more information, please see University of Manchester Benefits. You can also find information on our Flexible and Hybrid working.
Open Culture
We are an open place of enquiry and challenge. We embrace and celebrate difference, diversity and debate, and we pride ourselves on being a place of education, learning and community where we are able, within the law, to question and test received wisdom, express new ideas and explore controversial or unpopular topics and opinions. Find out more from our Freedom of Speech Policy.
Contact
Name: Prof Andrew Buller
Email: andrew.buller@manchester.ac.uk
General enquiries and administrative support: recruitmentservices.people@manchester.ac.uk
Technical and job portal support: https://jobseekersupport.jobtrain.co.uk/support/home
Applications close at midnight on the closing date.
RESEARCH ASSOCIATE IN ENZYME ENGINEERING AND BIOCATALYSIS in Manchester employer: Manchester University
The University of Manchester offers an exceptional environment for early career scientists, particularly in the field of enzyme engineering and biocatalysis. With a strong commitment to equality and diversity, generous benefits including a robust pension scheme and 29 days of annual leave, and a culture that fosters open inquiry and collaboration, this role provides a unique opportunity for professional growth and meaningful contributions to groundbreaking research. Located in the vibrant city of Manchester, employees benefit from a supportive community and access to world-class facilities.
StudySmarter Expert Advice🤫
We think this is how you could land RESEARCH ASSOCIATE IN ENZYME ENGINEERING AND BIOCATALYSIS in Manchester
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Some tips for your application 🫡
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Tailor Your Technical Skills:Make sure to emphasise your technical skills, especially those relevant to the biotechnology sector. Include any software tools or programming languages you've used, like R or Python for data analysis, which could be key for this role at Manchester University.
Craft a Compelling Cover Letter:Since this is a full-time role, your cover letter should reflect not only your passion for biotechnology but also your long-term career ambitions. Share why you're excited about the work that Manchester University does and how you envision contributing to their goals. This shows that you’re not just looking for any job, but you're genuinely invested in this opportunity.
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How to prepare for a job interview at Manchester University
✨Brush Up on Lab Techniques
Since you're eyeing a full-time gig in biotechnology, make sure you're well-versed in the lab techniques relevant to the role. Be ready to talk about PCR, CRISPR, or any specific methods mentioned in the job description at Manchester University. You might even be asked to demonstrate your understanding of these processes.
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Get comfortable with bioinformatics tools that are commonly used in the industry, like BLAST or Bioconductor. These are key in biotechnology, and having hands-on experience or at least familiarity can set you apart. Prepare to discuss any relevant projects you've worked on, especially if they involved data analysis or genomic research.
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Biotech often involves collaboration across multiple disciplines. Be ready to share stories that highlight your teamwork and communication skills, especially in research projects. Think about working with different teams at university or any internships – this is where you can show how well you fit into Manchester University's culture.
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Stay updated on the latest trends and breakthroughs in biotechnology. Knowing what's happening in the field can help you engage in more meaningful discussions during your interview. Bring up recent articles or advancements that excite you, especially those related to the work being done at Manchester University. This shows your passion for the industry!
