Research Assistant (91454) in Liverpool

An exciting opportunity has arisen for a Research Assistant to join the Functional Genetics Group at LSTM, led by Professor Tony Nolan. The post-holder will contribute to a new project within the Target Malaria research consortium, focused on developing and testing genetic approaches, including gene drive technologies, to reduce the global burden of malaria.

The role sits within the Department of Vector Biology, one of the largest of its kind, offering a vibrant and collaborative research environment. Building on recent advances demonstrating transgenesis and genome editing in Anopheles funestus, this project aims to develop effective gene drive strategies in this important malaria vector species.

The successful candidate will assist the Post-Doctoral Research Associate with experimental design, data collection and analysis, and preparation of manuscripts. Key responsibilities will include:

• Provide molecular biology support, including molecular genotyping and basic cloning, to senior researchers
• Assist in the design of genetic constructs for the generation of transgenic lines
• Follow standard molecular biology protocols (DNA/RNA extractions, PCR and qPCR)
• Design and execute plasmid cloning and screening procedures
• Perform basic bioinformatic analysis and plasmid and primer design
• Assist in the design of guide RNAs for CRISPR-based genome editing
• Maintain a range of mosquito lines, ensuring steady supply of mosquitoes for experiments
• Conduct and assist in the design of phenotypic assays of genetically edited mosquitoes
• Inject mosquito embryos with DNA constructs
• Analyse offspring of CRISPR-injected mosquitoes to identify genome editing or transgenesis events
• Data recording, presentation and analysis
• Collate and analyse data using Excel, Prism, R or other appropriate software
• Prepare written data reports and PowerPoint presentations
• Present results from experiments to update the research team and wider research group on progress and findings
• Provide initial analysis of data and draft sections of reports and manuscripts for funders, external collaborators and journal submissions under guidance of line manager
• Develop standard operating procedures and risk assessments
• Ensure laboratory space is kept clean, safe and well supplied
• Organise and maintain lab reagents
• Assist with supervision of students and visitors to the lab
• Assist with the planning and organisation of resources for the smooth running of the laboratory, including overseeing the ordering of apparatus, equipment components and materials

The ideal candidate will have excellent interpersonal skills and the ability to work as an integral and flexible member of a fast-paced multi-disciplinary research team. You will be able to demonstrate:

• BSc in Biological Science or science related subject (or equivalent experience)
• Hands-on experience of molecular biology, including DNA cloning
• Experience of working within a research laboratory
• Experience of providing laboratory supervision to lab visitors and students
• Familiarity with the general theory of genetic control approaches, including gene drive, for population control of insects

Generous occupational pension schemes, government backed “cycle to work” scheme, and affiliated, discounted staff membership to the University of Liverpool Sports Centre are also offered.

Application Process: To apply for the position please follow the apply link and upload your CV and covering letter. Due to the volume of applications, we receive, we may close our vacancies early. It is therefore advisable to apply as early as possible if you would like to be considered for a role.

Inclusion is central to our values at LSTM. We seek to attract and recruit people who reflect the diversity across our communities, regardless of sexual orientation, gender identity, ethnicity, nationality, faith or belief, social background, age and disability. LSTM selects candidates based on skills, qualifications, and experience. We welcome conversations about flexible working; and applications from those returning to employment after a break from their careers.

About LSTM: Founded in 1898 and the oldest of its kind in the world, the Liverpool School of Tropical Medicine (LSTM) is an internationally recognised centre of excellence for teaching and research in tropical diseases. Through the creation of effective links with governments, NGOs, private organisations and global institutions and by responding to the health needs of communities, LSTM aims to promote improved health, particularly for people of the less developed/resource poorest countries in the tropics and sub-tropics.