At a Glance
- Tasks: Develop and optimise innovative drug products using advanced modelling techniques.
- Company: Leading biopharmaceutical company focused on cutting-edge drug development.
- Benefits: Competitive hourly rate, collaborative environment, and opportunities for professional growth.
- Other info: Exciting opportunity to work with AI/ML tools in a fast-paced environment.
- Why this job: Join a dynamic team and make a real impact on patient outcomes through innovative science.
- Qualifications: PhD or MSc in relevant scientific field with experience in PBPK/PBBM modelling.
The predicted salary is between 20.66 - 20.66 £ per hour.
Senior Scientist, Biopharmaceutics Modelling & Simulation (PBBM/PBPK)
Location
Sandwich, Kent
Rate
£20.66 per hour PAYE | £23.15 per hour Umbrella
Job Type
12-month contract
Role Summary
We are seeking a highly motivated Senior Scientist with expertise in Physiologically Based Pharmacokinetic (PBPK) and Physiologically Based Biopharmaceutics Modelling (PBBM) to support the development and optimization of innovative drug products across all stages of development.
The successful candidate will apply mechanistic modelling and simulation approaches to understand and predict the impact of drug substance properties, formulation design, dissolution, physiology, and clinical variables on in vivo performance and patient outcomes.
The scientist will work within multidisciplinary project teams and collaborate closely with scientists in biopharmaceutics, formulation development, clinical pharmacology and PDM (Pharmacokinetics, Distribution and Metabolism) to support model-informed drug development and regulatory decision-making.
Key Responsibilities
- Develop, verify, and apply PBBM and PBPK models using platforms such as Simcyp, Gastro Plus or equivalent software.
- Support the prediction and assessment of oral absorption, food effect, bioavailability, formulation bridging, dissolution and particle size specifications, and virtual bioequivalence.
- Perform model calibration, sensitivity analyses, scenario testing, and uncertainty assessments to support project decisions.
- Collaborate with laboratory scientists to design and interpret in vitro studies supporting model development and verification.
- Support the development of clinically relevant dissolution methods and in vitro-in vivo links where appropriate.
- Communicate modelling outcomes through technical reports, project team presentations, regulatory documents, and scientific publications.
- Contribute to innovation in modelling methodologies, automation, and data-driven approaches, including AI/ML-enabled predictive tools where appropriate.
- Required Qualifications
- Ph D or MSc in Pharmaceutical Sciences, Biopharmaceutics, Pharmacokinetics, Pharmacometrics, Chemical Engineering or a related scientific discipline.
For MSc candidates, substantial relevant industrial experience in PBPK, PBBM, pharmacometrics, mechanistic modelling or model-informed drug development is required.
- Demonstrated expertise in PBPK, PBBM, pharmacometrics, mechanistic modelling, or model-informed drug development.
- Strong understanding of oral absorption, dissolution, permeability, biopharmaceutics, and pharmacokinetics.
- Experience with PBPK/PBBM modelling software such as Simcyp, Gastro Plus, PK-Sim or similar platforms.
- Demonstrated ability to apply modelling to solve pharmaceutical development challenges.
- Strong written and verbal scientific communication skills.
- Evidence of scientific productivity through publications, presentations, technical reports or regulatory contributions.
- Preferred Qualifications
- Experience supporting regulatory submissions involving PBPK or PBBM analyses.
- Experience with virtual bioequivalence or clinically relevant dissolution specifications.
- Working knowledge of Python, R, MATLAB, or other scientific programming tools.
- Experience applying machine learning or data science approaches to pharmaceutical development.
- Experience across multiple drug modalities, including poorly soluble compounds, enabling formulations, peptides, or complex dosage forms
Guidant, Carbon60, Lorien & SRG - The Impellam Group Portfolio are acting as an Employment Business in relation to this vacancy.
Senior Scientist, Biopharmaceutics Modelling & Simulation in Sandwich employer: Lorien Careers
Join a leading pharmaceutical company that values innovation and flexibility, offering a dynamic work culture where your contributions directly impact global health outcomes. With opportunities for professional growth and the ability to work remotely from Maidenhead, you will collaborate with a talented team on diverse projects across various therapy areas, ensuring a rewarding and meaningful experience in health economics modelling.
StudySmarter Expert Advice🤫
We think this is how you could land Senior Scientist, Biopharmaceutics Modelling & Simulation in Sandwich
✨Get Familiar with Temporary Roles in Pharma
Temporary positions in the pharmaceutical industry often arise during specific periods, like product launches or seasonal hiring sprints. Keep an eye on timelines and be proactive in reaching out to companies, especially around these busy times!
✨Join Pharma Networking Events
Participate in local and virtual pharmaceutical networking events or job fairs. This is a fantastic way to get in front of hiring managers and learn more about temporary opportunities directly from those in the know.
✨Leverage Your University Career Services
If you’re a student or recent grad, tap into your university’s career services which often have specific connections to pharma companies looking to fill temporary roles. They might even have exclusive internship programmes that lead to temp jobs!
✨Be Visible Online and Offline
Utilise platforms like LinkedIn to share your interests in temporary roles and connect with industry professionals. Plus, consider writing about relevant pharmaceutical topics to showcase your knowledge and enthusiasm—this can help you stand out to hiring companies like Lorien Careers.
We think you need these skills to ace Senior Scientist, Biopharmaceutics Modelling & Simulation in Sandwich
Some tips for your application 🫡
Highlight Your Relevant Experience:In the pharmaceutical industry, it's crucial to showcase any relevant experience you have, whether it's internships, lab work, or coursework. Let’s emphasise your familiarity with drug development processes and any hands-on experience you've had with lab equipment or clinical trials in your CV.
Mention Certifications and Training:If you’ve got any certifications relevant to pharmaceuticals, like Good Clinical Practice (GCP) or a certification in pharmacovigilance, make sure to include them. These show your commitment to the field and can make a positive impact on your application for a temporary role at Lorien Careers.
Show Your Flexibility and Availability:Temporary positions often require immediate availability and flexibility in working hours. In your cover letter, make it clear when you can start and your ability to adapt to changing schedules, as this is key to a successful application.
Express Your Learning Goals:Since this is a temporary role, we suggest discussing what you hope to learn or gain from the experience at Lorien Careers. This not only shows your eagerness but also helps employers see you as someone who’s ready to make the most out of the opportunity.
How to prepare for a job interview at Lorien Careers
✨Know Your Regulations
In the pharmaceutical industry, it’s crucial to understand key regulations like GMP (Good Manufacturing Practices) or GCP (Good Clinical Practices). Brush up on these standards and be ready to discuss how they influence your work approach during your interview with Lorien Careers.
✨Emphasise Adaptability
Since this is a temporary role, show that you're ready to hit the ground running. Share examples from your past experiences that demonstrate your ability to adapt quickly to new environments or changes, especially in a fast-paced setting like pharmaceuticals.
✨Highlight Relevant Skills and Tools
Whether it’s laboratory techniques or software like LabWare or SAS, make sure you can confidently talk about your technical skills. If you have experience with any specific tools used in previous roles, relate that directly to how it can help Lorien Careers achieve its goals.
✨Prepare for Technical Questions
Be ready for technical questions related to drug development processes or quality assurance. We should expect scenarios where you might have to troubleshoot a problem or suggest improvements on a project—this shows your problem-solving capability in a temporary role.
