University of Cambridge: Research Associate (Fixed Term)

The Medical Research Council Mitochondrial Biology Unit (MRC MBU), University of Cambridge wishes to appoint a post-doctoral Research Associate to join the research group of Prof. Michal Minczuk at the MRC Mitochondrial Biology Unit. A world-renowned centre for research, the MRC MBU is a vibrant community focused on the involvement of mitochondria and their dysfunction in an ever-increasing range of human diseases.

The postholder will contribute to an experimental medicine programme within the newly established LifeArc Centre for Rare Mitochondrial Diseases focused on therapeutic mitochondrial genome editing. Mammalian mitochondria contain multiple copies of their own genome (mtDNA), which encodes 13 essential subunits of the oxidative phosphorylation (OXPHOS) system. Pathogenic variants in mtDNA can lead to mitochondrial diseases, a significant group of inherited conditions affecting about 1 in 5,000 individuals. These disorders currently lack effective treatments and are incurable, with diverse penetrance, presentation, and prognosis. This project aims to address this treatment gap.

The objective of the project is to apply methods for precise genome editing to correct pre-clinical cellular and organoid models that mimic common features of mtDNA disease. We aim to analyse the reversion of mitochondrial dysfunction phenotypes using single-cell genomics, proteomics, and specialised methods for assessing mitochondrial function. In the longer term, the data obtained from these experiments will be used to develop a proof-of-concept first-in-human experimental medicine approach to reduce the pathogenic mtDNA mutation burden in muscle, as a path towards the development of a muscle-specific gene therapy approach. The project will be carried out in collaboration with mitochondrial patient support and community groups and involve industry partners, enhancing the potential for clinical translation and commercialisation of the technologies.

Candidates should have (or be nearing completion of) a PhD in a relevant subject and a record of related research achievements. Knowledge of in vivo gene delivery and experience with mitochondrial genome editing tools are essential.

This is a fixed-term position for 4 years from the date of appointment. The University of Cambridge is committed, in its pursuit of academic and research excellence, to a pro-active and inclusive approach to equality, which supports and encourages all under-represented groups, promotes an inclusive culture, and values diversity. The MBU is part of the School of Clinical Medicine, which holds an Athena Swan Silver Award and supports an Academic Women's Forum. The University particularly encourages women and candidates from Black, Asian and Minority Ethnic backgrounds to apply.

Applicants must have (or be close to obtaining) a PhD. Appointment at Research Associate level is dependent on having a PhD. Those who have submitted but not yet received their PhD will initially be appointed as a Research Assistant (Grade 5, Point 38 £34,132) moving to Research Associate (Grade 7) upon confirmation of your PhD award.

Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application. Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

Closing date: 10th June 2025. Interview date: To be confirmed. Please quote reference SM46103 on your application and in any correspondence about this vacancy. The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. The University has a responsibility to ensure that all employees are eligible to live and work in the UK.