Senior / Principal Scientist

Are you an ambitious scientist with a PhD and/or industry experience in bispecific or T-cell engager development, eager to accelerate novel cancer immunotherapies?Join a pioneering biotechnology company at the forefront of engineering TCR engagers for immuno-oncology application. This role is critical to advancing novel therapeutic candidates rapidly towards clinical development, with an IND submission targeted within a year.The client are seeking a dynamic Senior or Principal Scientist to lead crucial in vivo and in vitro validation of TCR engagers.This role specifically requires bispecific or T-cell engager experience with IND-enabling processes.Your technical responsibilities will span:TCR design and characterization.Protein science operations, including expression, purification, and biophysical analysis (e.g., SPR – experience preferred but not essential).Molecular biology duties such as cloning, mutagenesis, DNA isolation, and preparing libraries for deep sequencing (emphasis on cloning and PCR preferred).Cellular and immunological assays (e.g., cell killing assays, flow cytometry, IncuCyte-based assays, ELISA).Tissue culture management.Experience with NGS analysis pipelines (specifically data analysis using R) is desired.Experience overseeing outsourced in vivo studies (without needing to have performed them yourself) is a plus.You\’ll thrive in a flat hierarchy where everyone contributes hands-on. This is a fantastic opportunity for career progression, offering a highly collaborative and supportive cross-disciplinary environment. The client offers very competitive compensation, with flexibility for remote work as project demands allow.If you hold a PhD in Immunology, Cell Biology, Biochemistry, or a related field with 1-2+ years (Senior) or 3+ years (Principal) of relevant industry experience, and possess critical experience with bispecific or TCR engager validation towards IND, apply now to learn more about this impactful role!