At a Glance
- Tasks: Support groundbreaking research on novel therapies against pathogenic mycobacteria in a dynamic lab environment.
- Company: Join the Liverpool School of Tropical Medicine, a leader in tropical health research.
- Benefits: Enjoy 30 days annual leave, wellbeing support, and generous pension schemes.
- Other info: Opportunity for career growth with access to various learning and development resources.
- Why this job: Make a real impact in microbiology while developing your skills in a supportive setting.
- Qualifications: BSc in biological science and experience in microbiology or cell culture required.
The predicted salary is between 33951 - 38784 £ per year.
Full-time, fixed-term to 1st February 2027. Investigating novel therapies against pathogenic mycobacteria.
Responsibilities include laboratory maintenance and project-based activities. Essential experience in microbiology, cell culture, and genomics.
Salary: £33,951 - £38,784 p.a. (starting salary will be £33,951 p.a.). Full-Time, Fixed-term appointment to 1st February 2027 (possibility of extension subject to funding).
The Liverpool School of Tropical Medicine is seeking a Research Assistant to support a newly awarded MRC Impact Accelerator Account project investigating a novel host-directed therapy and antibiotic potentiator against pathogenic mycobacteria, including Mycobacterium abscessus and Mycobacterium tuberculosis.
The role will involve developing in vitro macrophage infection models, cytokine profiling, whole-genome sequencing of resistant bacteria, and investigating other Hazard Group 3 pathogens including Brucella spp.
The ideal candidate should have experience in microbiology, cell culture, immunology, molecular biology, or host-pathogen interactions, alongside experience with macrophage infection models, cytokine analysis, bacterial genomics, or pathogenic organisms. CL3 training and experience with Schedule 5 and SAPO-regulated work are essential.
Key responsibilities will include:
- General Laboratory Activities
- Support general maintenance tasks in the lab including media preparation, maintenance of bacterial cultures and autoclaving waste.
- Preparation of stock compounds, drugs, and reagents.
- Comply and implement all good working laboratory practices and health and safety regulations and assessments.
- Assist organisation, receipt and processing of clinical and reference bacterial strains.
- Project based laboratory activities
- Conduct checkerboard assays and MICs of bacterial strains.
- Perform multiplexed cytokine assays on treated vs non-treated cells.
- Work in Tissue Culture, CL2 and CL3 facilities to evaluate host directed therapy in a macrophage model of infection.
- Extract DNA and whole genome sequence bacteria cultured in various conditions.
- Assist with the supervision and training of postgraduate students working at CL2 and CL3.
- Project based office activities
- Analyse synergy of drug combinations using R packages.
- Map cytokine networks from data generated in the lab.
- Conduct command line bioinformatics of bacterial genomic data.
- Effectively prepare reports & presentations and communicate project updates at internal and external meetings.
- Assist in developing standard operating procedures and risk assessments and reviewing current health and safety documents.
Ideally you will demonstrate:
- BSc or equivalent in a biological science.
- MRes, MSc or equivalent in a biological science.
- Experience or training in microbiology and cell culture.
- Trained to work at CL3 with Schedule 5 and SAPO.
- Culture of Brucella clinical isolates for antimicrobial susceptibility testing.
- Experience of mycobacterial intracellular infection models for testing drugs.
- Maintenance and recording of laboratory data, methods and protocols.
Informal enquiries can be made to:
Additional benefits of joining LSTM:
- Access to support for your career growth through a variety of internal and external learning and development opportunities.
- Employee Assistance Platform offering a range of wellbeing initiatives and support, in addition to high-street discount offers.
- 30 days annual leave, plus 8 UK bank holidays, in addition to 6 Christmas closure days.
- Generous occupational pension schemes including USS (Universities Superannuation Scheme) and NHS pension schemes (subject to eligibility).
- Government backed 'cycle to work' scheme.
- Affiliated, discounted staff membership to the University of Liverpool Sports Centre.
- A range of enhanced family friendly policies.
Research Assistant (93186) employer: LGBT Jobs
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