Lead Biosensor Research Scientist in England

Level Zero is pioneering next-generation biosensor technology for precise, real-time monitoring of critical endocrine biomarkers. Recognised as one of the top 20 startups across all categories worldwide at TechCrunch Disrupt 2024 — and backed by top-tier organisations like SOSV and Entrepreneur First — we’re pushing the boundaries of biochemistry and nanotechnology to revolutionise personalised health. Our mission is bold: to revolutionise health management by delivering clinical-grade data directly to individuals, wherever they are.

We are excited to welcome a lead biosensor scientist with a strong background in lateral flow assay R&D, scale-up and experience in working with aptamers to join our rapidly growing start-up. The ideal candidate is expected to be proficient in bench and wet chemistry techniques. Moreover, they should have proven knowledge and experience in assay development and nanoparticle surface modifications (biomolecules, small molecules). It is essential for the candidate to have extensive experience in aptamer-based and antibody-based nanogold colourimetric biosensor R&D, including the designs, operation principles, troubleshooting, and analysis.

This is a full-time, in-person role primarily based in London.

• Lead the development and scale-up of LFA components and assay designs.
• Perform conjugation procedures between nanoparticles, aptamers, proteins, and small molecules, and optimize these procedures to meet performance parameters in assays.
• Validate aptamer biorecognition and the performance of functional gold nanostructures in different biological media using colourimetric assays.
• Fabricate biosensor devices, working from prototype iteration through to mass manufacture.
• Analyse and organise raw experimental data as technical reports.
• Work closely with the R&D leadership to optimize progress toward R&D milestones.
• Attend R&D-related trainings and seminars for continuous updates on the latest trends in hormone-sensing technologies.

• PhD in chemistry, materials science, biomedical engineering, bionanotechnology or a related discipline, with a focus in aptamer nanobiosensors.
• At least 4 years of industry experience.
• Proven knowledge and experience in lateral flow assay development, including launching assays to market.
• Proficiency in wet chemistry laboratory techniques, including nanomaterial characterisation and liquid-handling techniques.
• Experience and deep understanding of gold nanostructures: their use in biosensors, synthesis, and opportunities for surface modifications.
• Strong experience in assay development, particularly in unlocking key hurdles such as non-specific binding and signal-to-noise enhancement.
• Expertise in the R&D of colourimetric nanobiosensors and aptamer biorecognition.
• Experience with aptamers and small-molecule handling skills.
• Experience in leading a small team.

• Experience in gel electrophoresis and blotting methods.
• Experience with metallic nanostructure analytical skills such as ICP-MS or ICP-OES.

• We value culture as much as technical expertise, creating an environment that’s equal parts collaboration, curiosity, and fun.
• You live and breathe integrity, tackling challenges with honesty and transparency.
• You’re a self-starter who loves diving into the unknown, collaborating on complex problems, and taking full ownership of results.
• You excel at open, clear communication and see every piece of feedback as a springboard for growth—especially in a science and data-focused environment.
• You’re a technical leader capable of balancing complex timelines, motivating your team, and streamlining priorities.
• You’re motivated by creating real impact, particularly when advancing human health.
• You strike a balance between independence and collaboration, knowing when to seek support or invite others to join in.
• You’re confident in defending your ideas, while also valuing respectful, constructive debate as a path to better solutions.
• You thrive in the dynamic atmosphere of a startup, constantly evolving your skill set and fearlessly applying what you learn.

• A full-time role with a competitive salary and equity options, reflecting our value in your expertise and potential.
• An environment where you’ll collaborate directly with the founding team at a leading biosensor startup, gaining access to industry experts and thought leaders.
• The chance to grow with us, including ample opportunities for leadership, career advancement, and exploration.
• Travel to New York and other potential sites for R&D purposes.
• The excitement of working on cutting-edge technology, shaping strategic decisions, and driving innovation at an early-stage venture alongside a superstar team.

If you’re ready to be at the forefront of biosensing innovation and thrive in fast-paced, learning-rich environments, we’d love to hear from you. If your skills and experience do not align perfectly with this role, yet you believe you have something unique to offer, we’re keen to listen. Reach out to us with a short statement on how you can contribute and let’s discuss where you might fit into our team.

Location: London, United Kingdom