Principal / Senior Scientist, Translational Research - Clinical Assays and Companion Diagnostics in London

At LabGenius Therapeutics, our mission is to discover the next generation of therapeutic antibodies by combining human and machine intelligence. We’ve pioneered the development of EVA™, a state-of-the-art automated platform enabling the closed-loop discovery of high-performing, non-intuitive antibody designs using proprietary, ML-grade datasets. For our wholly-owned therapeutic pipeline, we’re using our closed-loop discovery engine to establish a pipeline of highly selective T-cell engagers and ADCs for the treatment of solid tumours. LabGenius has raised >£55M and is backed by top-tier investors. The company is headquartered in London (UK) where we’ve established a cutting-edge antibody engineering facility, staffed by a multidisciplinary team of more than 50 scientists and engineers.

An experienced Translational Scientist with a strong background in clinical immunology is needed to lead the clinical translation strategy for our advancing pipeline. This role focuses on the development, validation, and clinical implementation of biomarker and clinical PK/PD assays, as well as driving Companion Diagnostic (CDx) or patient-stratification strategies. You will oversee the transition of assays into clinical-grade tests, managing the internal technical transfer of mature assays from preclinical groups and directing the external tech transfer and scale-up to clinical CROs, reference labs, and central laboratories globally.

What you’ll do in this role:

• Clinical Assay Development: Oversee the development, optimization, and validation of robust clinical assays to measure T-cell engagement, peripheral B-cell/target-cell depletion, and soluble biomarkers.
• Vendor & Outsource Management: Audit, select, and manage relationships with specialized clinical CROs and diagnostic vendors, ensuring all transferred assays meet strict GxP and regulatory standards.
• Internal Clinical Tech Transfers: Partner with internal preclinical translational and discovery biology groups to pull mature, validated biomarker assays into the clinical translation workflow.
• External Clinical CRO Tech Transfers: Direct and manage the formal technical transfer of validated biomarker, PK/PD, and receptor occupancy assays from internal R&D to global clinical CROs.
• CDx & Stratification Strategy: Lead the development of Companion Diagnostics and clinical biomarker strategies tailored for IO and autoimmune therapies.
• Regulatory Report Writing & Review: Author and critically review assay validation plans, qualification reports, data transfer agreements, and the biomarker/diagnostic sections of clinical protocols.

What we’re looking for:

• Education: PhD in Immunology, Oncology, Molecular Diagnostics, or a related field with robust clinical translational experience in the biopharma industry.
• Bi-directional Tech Transfer Expertise: Proven success in pulling assays from internal groups and executing formal, documented assay tech transfers to external clinical CROs.
• Regulatory & Technical Documentation: Deep understanding of regulatory frameworks governing clinical assays alongside expert proficiency in writing and reviewing clinical study documents.
• Immunology Knowledge: Solid grasp of clinical IO endpoints and TCE-specific clinical challenges.
• Technical Platforms: Extensive experience with clinical assay modalities including multiplex Immunohistochemistry, flow cytometry panels, and high-sensitivity immunoassay platforms.

What you’ll receive from us:

• Discretionary performance-linked annual bonus
• A generous stock option plan
• 3x Salary Life Insurance
• Health cash back plan on day-to-day health expenses
• Enhanced pension contribution
• Private Medical Insurance, including dental and optical
• Discounted gym membership
• 24/7 access to GP Services
• Access to the Cycle to Work scheme
• 25 days annual leave (plus bank holidays)
• Paid sick leave and income protection for long term leave
• Paid emergency leave
• Paid bereavement leave
• Moving home day
• Employee Assistance Programme
• Weekly team lunches
• A programme of social events

We believe that diversity makes for innovative, exceptional teams. We are an equal opportunity employer and do not discriminate based on gender, race, colour, religion or belief, national origin, age, sexual orientation, marital status, disability, or any other protected class. If you don't feel like you meet every single requirement of this role, we still want to hear from you!