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- Tasks: Join our team to explore how influenza A virus manipulates host gene expression.
- Company: Be part of King's College London, a leader in infectious disease research.
- Benefits: Enjoy flexible working hours and professional development opportunities.
- Why this job: Contribute to impactful research while collaborating with passionate scientists.
- Qualifications: PhD in biological sciences required; experience in virology and molecular biology preferred.
- Other info: This is a fixed-term contract until 8 March 2026.
The predicted salary is between 28800 - 48000 £ per year.
This vacancy is open to internal applicants only.
About Us
The Regulatory Mechanisms in Transcription group in the Department of Infectious Diseases at King’s College London is uncovering how gene expression is adapted during host-pathogen interactions. We are interested in mechanisms that remove messenger (m)RNA from the translatable pool of mRNA through premature or delayed transcription termination mechanisms. Using influenza A virus and Candida albicans as pathogens, our studies reveal an intricate interplay between coding and non-coding fates of transcribed RNA that is frequently exploited by pathogens to shape the expressome to their advantage.
About the role
Viruses employ various approaches to avoid host cell defence mechanisms and coax host cells into virus particle production. During cellular influenza A infection, these include strategies to inhibit host gene transcription termination, preventing messenger (m)RNA polyadenylation, export, and translation. Although it is recognised that inhibition of host-gene mRNA expression aids the virus to promote expression of its own RNA (viral host shut off), not all circulating influenza strains are equally good at it, questioning its evolutionary importance.
We now seek a Postdoctoral Research Associate to join in our efforts to uncover the biological significance and mechanisms through which influenza A virus inhibits host gene transcription termination and mRNA expression. You will use a multidisciplinary approach that employs biochemistry, genetics, transcriptomics, molecular and cellular biology. You will be encouraged to use your own initiative and to work in collaboration with others to develop a comprehensive picture of how transcription termination affects RNA fate and consequently gene expression in influenza A infected cells.
The successful candidate will have obtained a PhD in a biological science such as molecular cell biology, virology or biochemistry. Experience with virology, in particular influenza A handling and rescue (cell-and egg-derived), titration through histochemistry, traditional plaque assays and FACS analysis; biochemistry, affinity interactome studies, mass-spectrometric analysis; cell-biology, in particular immunofluorescence, cellular fractionation; molecular biology, in particular cloning and RNA-expression analysis, library preparation and transcriptomics are desirable.
The appointee will be expected to show critical, innovative, but also methodological thinking. We are looking for individuals with a sound approach to problem solving, enthusiasm to disseminate their own research in seminars, conferences and research publications. Our laboratory is embedded in the highly collaborative department of infectious diseases. As a department, we are trying to nurture and train postdocs to be prepared for the academic and non-academic job market.
This is a full or part-time post (20 - 35 hours per week), and you will be offered a fixed term contract until 8 March 2026. Research staff at King’s are entitled to at least 10 days per year (pro-rata) for professional development.
Research Associate - INTERNAL ONLY - Strand, London, WC2R 2LS employer: King's College London
Contact Detail:
King's College London Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Research Associate - INTERNAL ONLY - Strand, London, WC2R 2LS
✨Tip Number 1
Familiarise yourself with the latest research in virology, particularly focusing on influenza A. This will not only help you understand the current challenges in the field but also allow you to engage in meaningful discussions during interviews.
✨Tip Number 2
Network with colleagues within the Department of Infectious Diseases. Building relationships with current staff can provide insights into the team dynamics and ongoing projects, which can be beneficial when discussing your fit for the role.
✨Tip Number 3
Prepare to showcase your problem-solving skills by thinking of specific examples from your past research experiences. Highlight how you've approached complex issues, especially in virology or molecular biology, as this aligns with the expectations of the role.
✨Tip Number 4
Demonstrate your enthusiasm for collaboration by being ready to discuss how you've worked effectively in teams before. The role emphasises a collaborative approach, so showing that you're a team player will make you stand out.
We think you need these skills to ace Research Associate - INTERNAL ONLY - Strand, London, WC2R 2LS
Some tips for your application 🫡
Understand the Role: Read the job description thoroughly to grasp the specific requirements and responsibilities of the Research Associate position. Highlight your relevant experience in virology, molecular biology, and any other areas mentioned.
Tailor Your CV: Customise your CV to reflect your qualifications and experiences that align with the role. Emphasise your PhD, relevant research projects, and any specific techniques or methodologies you have used that are mentioned in the job description.
Craft a Compelling Cover Letter: Write a cover letter that not only outlines your interest in the position but also demonstrates your understanding of the research group's work. Discuss how your skills and experiences make you a suitable candidate for the role.
Highlight Collaborative Experience: Since the role involves collaboration, mention any previous teamwork experiences in research settings. Showcase your ability to work with others and contribute to a collaborative environment, as this is valued in the department.
How to prepare for a job interview at King's College London
✨Know Your Research
Familiarise yourself with the latest research in virology, particularly regarding influenza A and its interaction with host cells. Be prepared to discuss how your previous work aligns with the group's focus on gene expression and transcription termination.
✨Showcase Your Skills
Highlight your experience with techniques mentioned in the job description, such as biochemistry, transcriptomics, and molecular biology. Be ready to provide specific examples of how you've applied these skills in past projects.
✨Demonstrate Collaboration
Emphasise your ability to work collaboratively within a team. Share experiences where you successfully collaborated with others to achieve research goals, as this role values teamwork and interdisciplinary approaches.
✨Prepare Questions
Have thoughtful questions ready about the group's current projects and future directions. This shows your genuine interest in the role and helps you assess if the position aligns with your career aspirations.
