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- Tasks: Manage the Islet Isolation Facility and ensure high standards for clinical cell transplantation.
- Company: Join King's College Hospital, a leader in innovative healthcare and research.
- Benefits: Indefinite contract, competitive salary, and opportunities for research development.
- Other info: Collaborative environment with excellent career growth and research opportunities.
- Why this job: Make a real difference in diabetes and transplant medicine while advancing your career.
- Qualifications: PhD or equivalent experience in health sciences, with strong management skills.
The predicted salary is between 55000 - 65000 £ per year.
About Us
We are seeking to appoint an Islet Isolation Facility Manager or Senior Islet Isolation Facility Manager, depending on experience, to the King's College Hospital Islet Isolation Laboratory. King's College Hospital Islet Isolation Laboratory is one of three HTA licensed facilities in the UK contributing to the national islet transplant programme. We receive donor pancreases and produce human islets for transplantation (by hepatic infusion). From our isolation centre, islets are shipped to a total of five possible NHS islet transplant centres: King's (our local clinical team), Oxford, Edinburgh, Manchester and Newcastle.
The King's Islet Isolation Laboratory sits within the Cell Therapy Unit in King's College Hospital, Denmark Hill. The unit was established in 2012 to prepare human cells from donor organs under Good Manufacturing Practice (GMP) conditions for clinical use. It is a joint facility shared by Bone Marrow Transplantation, engineered CAR‑T immunological therapy group, the Hepatocyte Biology and Transplantation Group and Islet Transplantation Group of King's College Hospital. This unit is a licensed cell isolation laboratory by Human Tissue Act Authorities to produce human tissue for clinical use and research. The lab also processes pancreases removed for the purpose of islet auto transplantation.
The King's Islet Isolation Team, under the leadership of Prof Victoria Salem, is also very closely linked with the King's College London Islet Biology Research Group and clinical diabetes service. The successful applicant will be based at the clinical trial unit (isolation facilities) in King's College Hospital and research offices in the adjacent James Black Centre at the Denmark Hill Hospital Campus within the School of Cardiovascular & Metabolic Medicine & Sciences (SCMMS). You will also be afforded research laboratory space in the Department of Diabetes at the Guy's Campus with the basic islet biology group. This provides an outstanding multi‑disciplinary environment for the pursuit of cutting‑edge diabetes, cardiovascular and metabolic research.
The Islet Isolation Facility Manager or Senior Islet Isolation Facility Manager will work as part of the senior clinical cell isolation team to ensure that the islet service is maintaining the standards required of a licensed laboratory by HTA Authority. You will also be part of the on call team and assist in the isolation of human pancreatic islets of Langerhans for clinical cell transplantation and for research. You will work very closely with Professor Victoria Salem, the clinical academic lead for the service, to ensure that the islet facility, auto‑ and allo‑transplant services are at the cutting edge of service delivery and research‑driven innovation.
Therefore, as well as ultimate responsibility of running the facility to HTA and GMP standards and line management of the 6 junior islet scientists, you will also maintain excellent collaborative ties with the UK islet transplant network such as attending national (NHSBT) Pancreas Advisory Group meetings, sharing best practice with other isolation centres and presenting islet science at national and international meetings. We also expect to support you to develop your own independent programme in human islet research.
Candidates without previous experience of human islet isolation but with a track record in high‑level laboratory practice and management, preferably in HTA approved facilities and previous independent research activity may be offered the G7 Islet Isolation Facility Manager, with a view to rapid upskilling in post. This is a full‑time post (35 hours per week), and you will be offered an indefinite contract. As part of the clinical isolation team you will be part of a 1:2 on‑call rota shared with the Oxford Islet Isolation Facility. In general, this on‑call rota rolls in 7‑day on/off cycles. During a typical on call period we receive on average one donor pancreas that takes up to 3 days to run through all the steps of digestion and culture prior to certified release of islets. This may therefore entail out of hours work during that on‑call period, and time off in lieu is provided to cover time that is spent isolating out of regular office hours. The team is designed to enable full coverage of annual, study and leave agreed in advance. It will also be understood that 50% of your time should be dedicated to research and service development. Since there is a strong expectation of research and development activity you will be afforded time for this element.
About You
To be successful in this role, we are looking for candidates to have the following skills and experience:
- Essential criteria – Grade 7
- PhD in a physical or health science discipline or equivalent experience with strong analytical and critical thinking skills
- Ability to assess and organise resources, plan and progress work activities effectively and manage and prioritise high workload and conflicting demands.
- Demonstrated ability to manage complex workflows, prioritise high‑pressure tasks, and coordinate 24‑hour service delivery
- Excellent communication skills (written and verbal), communicating with and engaging staff and diverse stakeholders with the ability to work collaboratively across functions and organisations
- Ability to devise solutions and develop creative approaches to solve problems
- Practical experience in scientific methods and techniques, specifically cGMP or Clean Room Practice.
- Experience of line and team management in a laboratory setting
- Understanding of HTA regulatory landscape
- Able to work a shift pattern, including on call, meeting the requirement to respond and get to site within 90 minutes
- Knowledge of islet research (particularly human islets)
- Knowledge of clinical islet isolation experience
- Experience of pancreatic islet biology, diabetic or transplant medicine
- Publication record
- PhD in a physical or health science discipline or equivalent experience with strong analytical and critical thinking skills
- Ability to assess and organise resources, plan and progress work activities effectively and manage and prioritise high workload and conflicting demands.
- Demonstrated ability to manage complex workflows, prioritise high‑pressure tasks, and coordinate 24‑hour service delivery
- Excellent communication skills (written and verbal), communicating with and engaging staff and diverse stakeholders at all levels with the ability to work collaboratively across functions and organisations
- Ability to devise solutions and develop creative approaches to solve problems
- Knowledge and experience of pancreatic islet biology, diabetic or transplant medicine.
- Practical experience in scientific methods and techniques and cGMP or Clean Room Practice
- Experience of line and team management in a scientific regulated laboratory setting
- Understanding of HTA regulatory landscape for clinical cell therapies
- Able to work a shift pattern, including on call, meeting the requirement to respond and get to site within 90 minutes
- Extensive clinical islet isolation experience
- Experience in Islet research (particularly human islets)
- Previous research experience in human islet isolation and islet transplantation
- Publication record
At King's, we believe that the diversity of our community and a culture that is welcoming, open, inclusive and collaborative, are great strengths of the university. The Equality Act of 2010 protects the rights of our students and staff and provides a framework to fulfil our duties to eliminate unlawful discrimination, harassment and victimisation and in addition, to advance equality of opportunity and foster good relations between those who share a protected characteristic and those who do not. At times, this will include balancing rights and beliefs that can feel in tension.
Islet Isolation Facility Manager or Senior Islet Isolation Facility Manager employer: King’s College London
Contact Detail:
King’s College London Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Islet Isolation Facility Manager or Senior Islet Isolation Facility Manager
✨Tip Number 1
Network like a pro! Reach out to professionals in the islet isolation and transplant field. Attend conferences, workshops, or even local meet-ups. You never know who might have a lead on your dream job!
✨Tip Number 2
Show off your skills! Prepare a portfolio or presentation that highlights your experience in islet isolation and management. This can be a great conversation starter during interviews and shows you're serious about the role.
✨Tip Number 3
Practice makes perfect! Conduct mock interviews with friends or mentors. Focus on articulating your experience with HTA regulations and GMP standards, as these are crucial for the role at King's College Hospital.
✨Tip Number 4
Apply through our website! It’s the best way to ensure your application gets noticed. Plus, we love seeing candidates who take the initiative to engage directly with us.
We think you need these skills to ace Islet Isolation Facility Manager or Senior Islet Isolation Facility Manager
Some tips for your application 🫡
Tailor Your Application: Make sure to customise your CV and cover letter to highlight your relevant experience and skills that match the job description. We want to see how your background aligns with our needs at the Islet Isolation Facility.
Showcase Your Communication Skills: Since excellent communication is key for this role, don’t shy away from demonstrating your written and verbal skills in your application. Use clear and concise language to convey your ideas and experiences.
Highlight Relevant Experience: If you have experience in HTA licensed facilities or scientific methods, make it front and centre in your application. We’re looking for candidates who can manage complex workflows and understand the regulatory landscape.
Apply Through Our Website: We encourage you to submit your application through our website. It’s the best way to ensure your application gets to us directly and is considered promptly. Plus, it’s super easy!
How to prepare for a job interview at King’s College London
✨Know Your Stuff
Make sure you brush up on your knowledge of islet biology and the latest research in the field. Familiarise yourself with the HTA regulatory landscape and Good Manufacturing Practice (GMP) standards, as these will be crucial in your role.
✨Showcase Your Leadership Skills
As a potential manager, it's important to demonstrate your ability to lead a team effectively. Prepare examples of how you've managed complex workflows or high-pressure situations in the past, and be ready to discuss your approach to line management.
✨Communicate Clearly
Excellent communication skills are key for this role. Practice articulating your thoughts clearly and concisely, especially when discussing technical topics. Be prepared to engage with diverse stakeholders and show how you can foster collaboration across functions.
✨Be Ready for Problem-Solving
Expect questions that assess your problem-solving abilities. Think of specific challenges you've faced in previous roles and how you devised creative solutions. Highlight your analytical skills and your ability to think critically under pressure.