At a Glance
- Tasks: Develop predictive models of epigenetic dynamics and collaborate with top researchers.
- Company: Join the prestigious John Innes Centre at Oxford University.
- Benefits: Access to cutting-edge technology, training opportunities, and a supportive research environment.
- Other info: Work in an interdisciplinary team with excellent career advancement potential.
- Why this job: Make a real impact in understanding fundamental biological processes.
- Qualifications: PhD in Theoretical Physics, Bio-Mathematics, or Computational Biology preferred.
The predicted salary is between 36000 - 60000 £ per year.
Overview
The main purpose of the position is to develop predictive computational models of epigenetic dynamics, collaborating with the experimental group of Prof Rob Klose in the Dept of Biochemistry, Oxford University. The models will enhance understanding of how the Polycomb system silences gene expression and how a silenced memory state can be stably maintained through many cell cycles. The position is funded by Wellcome and would suit an individual with a high degree of independence and vision, able to advance the project independently. The successful candidate will have a rare opportunity to work on fundamental biological processes in an interdisciplinary environment, with seamless collaboration with a leading experimental group.
The ideal candidate will possess (or soon complete) a PhD in Theoretical Physics, Bio-Mathematics or Computational Biology. They will possess a strong interest in biological problems and have achieved demonstrable scientific success in previous roles. Prior experience of biological modelling is desirable but not essential.
Languages: ENGLISH
About the John Innes Centre
The John Innes Centre is an independent, international centre of excellence in plant and microbial sciences. We nurture a creative, curiosity-led approach to answering fundamental questions in bioscience, and translate that knowledge into societal benefits. Our strategic vision, Healthy Plants, Healthy People, Healthy Planet, sets out our ambitious long-term goals for the game changing impact of our science globally. Our employees enjoy access to state-of-the-art technology and a diverse range of specialist training opportunities, including support for leadership and management. Click here to find out more about working at the John Innes Centre.
About the Howard Group
The Howard group combines simple, predictive mathematical and biophysical modelling with long-lasting experimental collaborations to dissect biological mechanisms too complex to unravel by experiments alone. In many cases we are able to rationalise complex biological dynamics into simple underlying mechanisms, with few components and interactions.
Our approach is highly interdisciplinary and relies heavily on the techniques of statistical physics and applied mathematics, as well as on close collaboration with experimental groups. At present there are two main research areas in the group: probing how epigenetic memory states are set up and then stably maintained, and understanding patterning dynamics in sub-cellular biological systems. For epigenetics, we work on both histone modification memory systems, particularly the Polycomb silencing system, as well as on DNA methylation. For patterning, the main application at present is to the dynamics of crossover positioning in meiosis.
The group regularly publishes in the most prominent multidisciplinary journals, with recent papers in Nature, Science, Cell Systems, eLife, Molecular Cell and PNAS. Several previous members of the Howard group now hold independent faculty positions of their own, including in Warwick, Glasgow, Sydney, Amsterdam and Munich.
Job offer Postdoctoral Researcher employer: John Innes Centre
The John Innes Centre offers an exceptional environment for a Postdoctoral Researcher, fostering a culture of creativity and collaboration in the heart of Oxford. With access to cutting-edge technology and a commitment to employee development through diverse training opportunities, you will be part of a pioneering team dedicated to advancing our understanding of epigenetic dynamics. This role not only provides a unique chance to contribute to impactful research but also positions you within a vibrant academic community that values independence and innovation.
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We think this is how you could land Job offer Postdoctoral Researcher
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We think you need these skills to ace Job offer Postdoctoral Researcher
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