Principal Database Programmer

Principal Database Programmer – United States, Poland, Portugal, Spain, United Kingdom, Sweden

As a Principal Database Programmer, you will play a critical role in leading and executing database programming activities that support clinical studies. You will provide technical leadership, mentor junior programmers, and ensure the delivery of high‑quality, compliant, and efficient data management solutions. This role involves designing, validating, and maintaining databases, collaborating with cross‑functional study teams, and implementing best practices to improve operational performance. You will manage project deliverables, budgets, and system validation while contributing to the development of internal processes and standards. Your work will directly impact the accuracy, reliability, and timeliness of clinical trial data in a dynamic, remote‑friendly, and globally distributed environment.

Responsibilities

• Lead database programming activities for assigned clinical studies, ensuring compliance with regulatory requirements and internal standards
• Mentor and train junior database programmers on CDMS systems, programming practices, and study‑specific processes
• Set up and validate study databases and ePRO/IRT systems based on provided specifications
• Review and implement Data Validation Plans, perform database validation and UAT, and support data import/export tasks
• Collaborate with cross‑functional teams to manage project deliverables, budgets, and study timelines
• Support clinical data management activities, including executing database locks and providing user support for EDC studies
• Contribute to process improvement, SOP development, and system validation initiatives

Requirements

• Bachelor\’s degree in Life Sciences, Computer Science, or a related field
• Minimum of 8 years of database programming experience in the pharmaceutical or CRO industry, including at least 5 years at a senior level
• Proficiency with CDMS systems and understanding of industry standards for programming in GxP environments (e.g., 21 CFR Part 11, GAMP)
• Experience with SAS programming, data listings, SDTM datasets, and define.XML is preferred
• Strong leadership skills with the ability to manage multiple tasks and meet deadlines
• Excellent verbal and written communication skills with the ability to work effectively with sponsors and internal teams
• Client‑facing experience, including participating in bid defense meetings, is a plus
• Ability to work effectively in a remote and globally distributed team environment

Benefits

• Competitive salary and performance‑based bonuses
• Flexible work arrangements, including fully remote options
• Opportunities for personal and professional development in a global clinical research environment
• Collaborative team culture that values mentorship, innovation, and operational excellence
• Exposure to diverse clinical studies across multiple therapeutic areas
• Contribution to projects that directly impact patient outcomes and clinical research advancement