At a Glance
- Tasks: Analyse ecDNA evolution using single cell RNA/ATAC sequencing and develop ctDNA detection approaches.
- Company: Join a vibrant, highly collegiate environment at UCL, London's Global University.
- Benefits: Enjoy 41 days holiday, a defined benefit pension scheme, and an on-site gym.
- Other info: Position is fixed term for 2 years, with potential for backdated payment upon PhD submission.
- Why this job: Contribute to groundbreaking research in cancer evolution and biomarker development.
- Qualifications: Proven track record in publications and experience with genomics data analysis required.
The predicted salary is between 40000 - 50000 £ per year.
We are seeking a collaborative and self-motivated bioinformatician postdoctoral fellow to work on extrachromosomal DNA (ecDNA) in a vibrant, highly collegiate environment. ecDNA are circular genomic structures that can drive ultra high copy number amplification and correlate with poor clinical outcomes. This project will analyse ecDNA evolution over time using single cell RNA/ATAC sequencing and develop a ctDNA based approach for detecting and monitoring ecDNA to support biomarker and treatment development.
The research will utilise existing whole genome sequencing data from the TRACERx lung cancer evolution and PEACE research autopsy programmes, and will be part of the eDyNAmiC Cancer Grand Challenge. The work will involve analysing large multi-region matched primary and metastatic tumour datasets, developing computational pipelines for ecDNA detection, and integrating ctDNA biomarker data to provide translational insights.
Successful applicants should have a proven track record of publications, previous experience with genomics data analysis, and fluency in at least one of the following programming languages: C++, Python or R. Strong skills in genomics and desirably experience in tumour biology, ctDNA/blood based biomarkers, evolutionary biology, statistics or mathematics are required.
Appointment at Grade 7 is dependent upon having been awarded a PhD; if this is not the case, initial appointment will be at Research Assistant Grade 6B, with payment at Grade 7 backdated to the date of final submission of the PhD thesis.
What we offer:
- 41 days holiday (including 27 days annual leave, 8 bank holidays and 6 closure days)
- Defined benefit career average revalued earnings pension scheme (CARE)
- Cycle to work scheme and season ticket loan
- On site gym
- Enhanced maternity, paternity and adoption pay
- Employee assistance programme: Staff Support Service
As London's Global University, we know diversity fosters creativity and innovation, and we want our community to represent the diversity of the world's talent. We are committed to equality of opportunity, fairness and inclusiveness, and to being a place where everyone belongs. We especially encourage applications from candidates likely to be underrepresented in UCL's workforce, including people from Black, Asian and ethnic minority backgrounds; disabled people; LGBTQI+ people; and for our Grade 9 and 10 roles, women.
Research Fellow - Bioinformatics - Extrachromosomal DNA and tumour evolution Scientist in London employer: Job Search Place Limited
UCL offers a dynamic research environment with a commitment to equality and diversity. Located in London, it provides extensive benefits including enhanced parental leave and a supportive employee assistance programme. The team focuses on innovative cancer research, making significant contributions to the field.
StudySmarter Expert Advice🤫
We think this is how you could land Research Fellow - Bioinformatics - Extrachromosomal DNA and tumour evolution Scientist in London
✨Get Involved in Local Research Communities
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We think you need these skills to ace Research Fellow - Bioinformatics - Extrachromosomal DNA and tumour evolution Scientist in London
Some tips for your application 🫡
Show Off Your Lab Skills:In the biotechnology field, it's super important to highlight your lab experience in your CV. Be sure to mention specific techniques or instruments you've mastered (think PCR, gel electrophoresis, etc.) and any relevant projects you've worked on. This will show Job Search Place Limited that you have the hands-on skills they need.
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Craft a Compelling Cover Letter:Since this is a full-time role, your cover letter should reflect not only your passion for biotechnology but also your long-term career ambitions. Share why you're excited about the work that Job Search Place Limited does and how you envision contributing to their goals. This shows that you’re not just looking for any job, but you're genuinely invested in this opportunity.
Include Your Papers and Projects:If you've published any papers or contributed to significant projects, mention them! These documents can boost your application and provide tangible evidence of your expertise in the biotechnology field. Don’t forget to link to any relevant publications or project summaries—this can set you apart from other candidates.
How to prepare for a job interview at Job Search Place Limited
✨Brush Up on Lab Techniques
Since you're eyeing a full-time gig in biotechnology, make sure you're well-versed in the lab techniques relevant to the role. Be ready to talk about PCR, CRISPR, or any specific methods mentioned in the job description at Job Search Place Limited. You might even be asked to demonstrate your understanding of these processes.
✨Know Your Bioinformatics Tools
Get comfortable with bioinformatics tools that are commonly used in the industry, like BLAST or Bioconductor. These are key in biotechnology, and having hands-on experience or at least familiarity can set you apart. Prepare to discuss any relevant projects you've worked on, especially if they involved data analysis or genomic research.
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✨Research Recent Biotech Innovations
Stay updated on the latest trends and breakthroughs in biotechnology. Knowing what's happening in the field can help you engage in more meaningful discussions during your interview. Bring up recent articles or advancements that excite you, especially those related to the work being done at Job Search Place Limited. This shows your passion for the industry!
