At a Glance
- Tasks: Lead a scientific team in oncology pharmacology from discovery to regulatory approval.
- Company: Join Jazz Pharmaceuticals, a global biopharma innovating life-changing medicines.
- Benefits: Competitive salary, bonuses, flexible vacation, and comprehensive health benefits.
- Other info: Dynamic work environment with opportunities for mentorship and career growth.
- Why this job: Make a real impact in oncology and help transform patients' lives.
- Qualifications: Ph.D. in relevant fields with extensive oncology drug development experience.
The predicted salary is between 51750 - 63250 £ per year.
Jazz Pharmaceuticals is a global biopharma company whose purpose is to innovate to transform the lives of patients and their families. We are dedicated to developing life-changing medicines for people with serious diseases — often with limited or no therapeutic options. We have a diverse portfolio of marketed medicines, including leading therapies for sleep disorders and epilepsy, and a growing portfolio of cancer treatments. Our patient-focused and science-driven approach powers pioneering research and development advancements across our robust pipeline of innovative therapeutics in oncology and neuroscience. Jazz is headquartered in Dublin, Ireland with research and development laboratories, manufacturing facilities and employees in multiple countries committed to serving patients worldwide.
Brief Description
This individual will be responsible for leading scientific team members assigned to oncology assets ranging from discovery through regulatory approval. This individual will both manage the oncology pharmacology team and serve a lead on one or more programs themselves. Primary responsibilities of the oncology pharmacology team include:
- Establishing efficacy in relevant disease models
- Demonstrating differentiation relative to relevant comparators
- Determining PK/PD/efficacy relationships
- Characterizing mechanisms of action
- Identifying predictive disease models, indications, and biomarkers
- Driving preclinical discovery
- Supporting research and development of Jazz products and drug candidates overall
- Designing and executing studies that address clinically relevant priorities
Operational tasks include:
- Designing and executing experiments that are outsourced or performed by in-house bench researchers or academic collaborators
- Reviewing and contributing to clinical protocols
- Reviewing and authoring technical reports
- Coauthoring sections of regulatory documents ranging from IND to NDA/BLA submissions
- Communicating relevant research at internal and external forums
The oncology pharmacology team is cross-functional, including participation in matrix teams assigned to specific products that include but are not limited to Clinical Development, Bioanalytical, Toxicology, Clinical Pharmacology, Biomarkers Regulatory Affairs, and Project Management. Collaborate with and represent ORP on internal teams—to design, develop, implement, and oversee execution of strategies and experiments supporting nonclinical studies in hematologic malignancies and solid tumors.
Essential Functions
- Design and execute experiments to elucidate efficacy, tolerability, mechanism of action, and biomarkers associated with complex combinations of multiple therapeutic modalities (small molecules, biologics, ADCs, bi-specifics, cell therapies, and other emerging platforms)
- Critically evaluate biochemical and cellular assays
- Communicate effectively across JAZZ functional teams, highly matrixed, cross functional environments
- Demonstrate strong interpersonal, negotiation, and influence skills
- Independently develop experimental strategies, analyze data, and present results to non‑clinical and governance-level teams
- Collaborate with CROs to outsource studies, develop protocols, manage timelines and budgets, and partner with academic labs for Jazz sponsored research
- Serve as a project team leader and/or as lead pharmacology representative across various oncology programs
- Mentor junior scientists and provide scientific leadership and professional growth opportunities
Required Knowledge, Skills, and Abilities
- Industry experience evaluating therapeutic potential of drug candidates from hit to lead optimization through discovery to late phase studies, with deep expertise in oncology drug development
- Broad background in preclinical oncology with strong familiarity with emerging therapeutic modalities, competitive landscapes, and strategic assessment of diverse drug mechanisms
- Extensive experience in Immuno Oncology (I/O), including I/O relevant in vivo and in vitro models, immune cell biology, and integration of immunological endpoints into pharmacology programs
- Demonstrated experience working across multiple drug modalities, including small molecules, biologics, ADCs, bi-specifics, T cell engagers, cell and gene therapies, and RNA based therapeutics
- Strong foundational understanding of the interdependencies between Nonclinical Pharmacology, Toxicology, DMPK, and Clinical Pharmacology
- Deep understanding of cancer signaling pathways and their therapeutic exploitation
- Proven experience leading multiple complex pharmacology programs at diverse CROs, including GLP and non-GLP environments
- Expertise designing and executing studies evaluating efficacy, tolerability, mechanism of action, and biomarker strategies for small molecule and biologic agents
- Ability to integrate preclinical and clinical datasets, innovate, and apply novel methodologies to advance therapeutic programs
- Proficiency with analytical tools (e.g., GraphPad Prism) and biomarker data analysis
- Direct people management experience, including mentorship, performance development, and leadership of scientific teams
- Strong leadership qualities, self motivation, and demonstrated success networking across internal teams, academia, industry, and regulatory agencies
- Excellent ability to assess program needs, oversee CRO activities, develop/review protocols, monitor execution, interpret results, and prepare high quality reports for regulatory submissions
- Experience authoring nonclinical components of IND, NDA/BLA/MAA submissions, briefing packages, DSURs, IBs, and fast track designation documents
- Strong project management skills with the ability to manage multiple complex programs simultaneously
- Demonstrated success leading in fast paced, highly matrixed environments, aligning diverse stakeholders and driving decision making
- Strong analytical and creative problem-solving skills
- Embody and model Jazz core values
Required/Preferred Education and Licenses
- Ph.D. in biology, biochemistry, immunology, pharmacology, or a related discipline, with experience leading early oncology programs and developing nonclinical models for characterizing therapeutic efficacy and pharmacodynamics, including substantial oncology and immuno-oncology experience
Senior Director, Oncology Pharmacology in City of London employer: Jazz Pharmaceuticals
Jazz Pharmaceuticals is an exceptional employer, offering a dynamic work culture that prioritises innovation and collaboration in the biopharma industry. With a strong commitment to employee growth, we provide numerous opportunities for professional development and a competitive benefits package, including flexible paid vacation and comprehensive health insurance. Located in vibrant cities like London and Cambridge, our employees enjoy a stimulating environment that fosters creativity and teamwork while making a meaningful impact on patients' lives worldwide.
StudySmarter Expert Advice🤫
We think this is how you could land Senior Director, Oncology Pharmacology in City of London
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We think you need these skills to ace Senior Director, Oncology Pharmacology in City of London
Some tips for your application 🫡
Showcase Your Relevant Experience:When applying for a role in the pharmaceutical industry, it's crucial to highlight any relevant experience you have. Whether that's internships, lab work, or even related coursework, make sure to weave this into your CV and cover letter. We want to see how your background aligns with the role you're applying for at Jazz Pharmaceuticals!
Emphasise Your Understanding of Regulations:The pharmaceutical industry is heavily regulated, so it's important to indicate your familiarity with industry standards and regulations. In your cover letter, mention any training or certifications you've received that are relevant, or discuss projects where you’ve navigated compliance. This will show Jazz Pharmaceuticals that you're not just a fit for the job but also a safety-conscious candidate!
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How to prepare for a job interview at Jazz Pharmaceuticals
✨Understand the Science
Make sure you brush up on key pharmaceutical concepts and recent developments in the industry. You might get asked some technical questions during the interview at Jazz Pharmaceuticals that show your grasp of drug development processes or regulatory requirements, so be ready to discuss them clearly.
✨Showcase Relevant Experience
If you have any hands-on experience or internships in a laboratory setting, be sure to highlight these in your responses. Think about the projects you worked on, the methodologies you used, and the impact you made. It's all about telling a story that connects your background to the role you're applying for.
✨Know Their Products
Take some time to familiarise yourself with Jazz Pharmaceuticals’s product range and recent breakthroughs. Understanding their portfolio not only shows your enthusiasm for the role but also allows you to ask insightful questions that demonstrate your interest in actively contributing to their projects.
✨Be Ready for Regulatory Scenarios
In a full-time pharmaceutical role, understanding the regulatory landscape is crucial. Prepare for situational questions that may test your problem-solving skills concerning compliance and safety standards. You could be asked how you'd handle a hypothetical issue regarding a drug’s market release, so think through your approach.
