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- Tasks: Lead safety assessments for innovative drug discovery projects using AI-driven strategies.
- Company: Join Isomorphic Labs, a pioneering company in AI and drug design.
- Benefits: Competitive salary, hybrid working model, and opportunities for professional growth.
- Why this job: Make a real impact on global health by advancing drug discovery with cutting-edge technology.
- Qualifications: Ph.D. in Toxicology or related field with 7-10 years of experience.
- Other info: Collaborative culture focused on inclusion and continuous learning.
The predicted salary is between 72000 - 108000 Ā£ per year.
About Isomorphic Labs
Isomorphic Labs (IsoLabs) was launched in 2021 to advance human health by building on and beyond the Nobel-winning AlphaFold system. Since then, our interdisciplinary team of drug discovery experts and machine learning specialists has built powerful new predictive and generative AI models that accelerate scientific discovery at digital speed. Our name comes from the belief that there is an underlying symmetry between biology and information science. By harnessing AI's powerful capabilities, we can model complex biological phenomena to design novel molecules, anticipate drug performance, and develop innovative medicines for some of the world's most devastating diseases. We have built a worldāleading drug design engine and continually innovate on model architecture and capabilities to advance rational drug design. Every day, we get closer to the promise of digital biology and our ambitious mission to solve all disease with the help of AI.
Preclinical Development Team
The Preclinical Development team accelerates delivery of highāquality candidates by developing innovative, AIāfirst solutions. Collaboration with drug discovery disciplines and AI/ML researchers ensures safety, druggability, and developability are central to our drug design engine. We shape the development of stateāofātheāart toxicology predictive models and rethink drug discovery from HitID to First in Human trials by optimizing model context.
Toxicology Lead ā Your Impact
As a Toxicology Lead, you will develop safety assessment strategies for drug discovery and development projects from inception to regulatory submission. Working closely with the drug design platforms (small molecules and biologics), you will drive the optimisation of Iso's assets with an AIāfirst approach. You will guide development of our AI predictive toxicology platform to increase success probability and contribute to reducing animal testing in collaboration with AI/ML research and data strategy teams.
What You Will Do
- Design and implement safety assessment strategies with an AIāfirst approach for small molecules and biologics drug discovery projects.
- Design screening cascades and mechanistic experiments to support project progression in a dataādriven manner.
- Develop SAR understanding of toxicology main liabilities to optimise chemical and biological matter where needed.
- Define regulatory safety assessment packages to support successful acceptance by regulatory agencies.
- Author toxicology sections of regulatory documents.
Predictive toxicology strategy
- Partner with Machine Learning colleagues to build the predictive toxicology aspects of the drug design platform and identify, generate and analyse data to develop and improve predictive toxicology models.
- Identify stateāofātheāart technologies and methods that could bring transformational benefits to our platform or ways of working.
CRO interactions
- Maintain and develop close relationships with the CRO network to ensure high quality and timely data generation.
- Leverage external scientific expertise to enhance the team's impact.
- Oversee delivery of data generation campaigns purposefully designed to support AIābased toxicology models.
People
- Mentor junior members of the team.
- Embrace and champion a culture of inclusion and continuous professional development.
Skills and Qualifications
- Essential Ph.D. in Toxicology, Pharmacology, Biology, or DVM/MD with relevant experience.
- Board certification.
- 7ā10+ years of professional experience in a Toxicology role within biotech or pharma.
- Demonstrated experience filing successful INDs/CTAs for small molecules and biologics.
- Deep understanding of global regulatory guidelines for safety assessment.
- Experience partnering closely with Discovery and Clinical teams.
- Excellent written and verbal communication and interpersonal skills.
- Track record of creative problem solving with a growth mindset, adaptability, and eagerness to learn new concepts.
Nice to have
- Experience with peptides and other new modalities.
- Good understanding of machine learning techniques.
- Familiarity with Python and KNIME.
Culture and values
- Thoughtful ā curiosity, creativity, and care.
- Brave ā fearlessness, initiative, and integrity.
- Determined ā confidence in hypotheses and urgency.
- Together ā collaboration and catalytic relationships.
Hybrid working
We follow a hybrid model and require you to come into the office 3 days a week (currently Tuesday, Wednesday, and one other day depending on your team). If you have additional needs that prevent you from following this hybrid approach, we'd be happy to discuss accommodations if you're selected for an initial screening call.
Equal Employment Opportunity Statement
We are committed to equal employment opportunities regardless of sex, race, religion or belief, ethnic or national origin, disability, age, citizenship, marital, domestic or civil partnership status, sexual orientation, gender identity, pregnancy or related condition (including breastfeeding) or any other basis protected by applicable law. If you have a disability or additional need that requires accommodation, please let us know.
Toxicology Lead, London, Lausanne employer: Isomorphic Labs
Contact Detail:
Isomorphic Labs Recruiting Team
StudySmarter Expert Advice š¤«
We think this is how you could land Toxicology Lead, London, Lausanne
āØTip Number 1
Network like a pro! Reach out to people in the industry, attend relevant events, and connect with professionals on LinkedIn. You never know who might have the inside scoop on job openings or can put in a good word for you.
āØTip Number 2
Prepare for interviews by researching the company and its culture. Understand their mission and values, especially how they relate to AI and drug discovery. This will help you tailor your answers and show that you're genuinely interested in joining the team.
āØTip Number 3
Practice makes perfect! Conduct mock interviews with friends or use online platforms to get comfortable with common questions. Focus on articulating your experience in toxicology and how it aligns with the role at Isomorphic Labs.
āØTip Number 4
Donāt forget to apply through our website! Itās the best way to ensure your application gets seen. Plus, it shows youāre serious about wanting to be part of our innovative team at Isomorphic Labs.
We think you need these skills to ace Toxicology Lead, London, Lausanne
Some tips for your application š«”
Tailor Your Application: Make sure to customise your CV and cover letter for the Toxicology Lead role. Highlight your relevant experience in toxicology and any AI-driven projects you've worked on. We want to see how your background aligns with our mission at Isomorphic Labs!
Showcase Your Communication Skills: Since excellent written communication is key, ensure your application is clear and concise. Use straightforward language and avoid jargon unless necessary. We appreciate a well-structured application that reflects your ability to communicate complex ideas effectively.
Demonstrate Your Problem-Solving Mindset: In your application, share examples of creative problem-solving from your past experiences. We love candidates who can think outside the box and adapt to new challenges, especially in the fast-paced world of drug discovery and AI.
Apply Through Our Website: We encourage you to submit your application directly through our website. This way, youāll ensure it reaches the right people and stands out in our system. Plus, itās super easy and quick to do!
How to prepare for a job interview at Isomorphic Labs
āØKnow Your Stuff
Make sure you brush up on your toxicology knowledge, especially around safety assessment strategies and regulatory guidelines. Be ready to discuss your past experiences with filing INDs/CTAs and how you've tackled challenges in drug discovery.
āØShowcase Your AI Savvy
Since the role involves an AI-first approach, highlight any experience you have with machine learning techniques or predictive modelling. If youāve worked with Python or KNIME, be sure to mention it and discuss how you can leverage these skills in the role.
āØCollaboration is Key
Isomorphic Labs values teamwork, so be prepared to talk about how you've collaborated with cross-functional teams in the past. Share examples of how youāve partnered with Discovery and Clinical teams to drive projects forward.
āØEmbrace the Culture
Familiarise yourself with the companyās values: Thoughtful, Brave, Determined, and Together. Think of examples from your career that demonstrate these traits, as theyāll want to see how you fit into their culture and contribute to a positive work environment.
