Team Leader, Medicinal Drug Design, London, Lausanne

Isomorphic Labs is applying frontier AI to help unlock deeper scientific insights, faster breakthroughs, and life-changing medicines with an ambition to solve all disease. The future is coming. A future enabled and enriched by the incredible power of machine learning. A future in which diseases are curtailed or cured starting with better and faster drug discovery. Come and be part of an interdisciplinary team driving groundbreaking innovation and play a meaningful role in contributing towards achieving our ambitious goals, while being part of an inspiring and collaborative culture.

Isomorphic Labs (IsoLabs) was launched in 2021 to advance human health by building on and beyond the Nobel-winning AlphaFold system. Since then, our interdisciplinary team of drug discovery experts and machine learning specialists has built powerful new predictive and generative AI models that accelerate scientific discovery at digital speed. Our name comes from the belief that there is an underlying symmetry between biology and information science. By harnessing AI's powerful capabilities, we can model complex biological phenomena to help design novel molecules, anticipate how drugs will perform, and develop innovative medicines to treat and cure some of the world's most devastating diseases. We have built a world‐leading drug design engine comprising AI models that are capable of working across multiple therapeutic areas and drug modalities. We are continually innovating on model architecture and developing cutting‐edge capabilities to advance rational drug design. Every day, and with each new breakthrough, we're getting closer to the promise of digital biology, and achieving our ambitious mission to one day solve all disease with the help of AI.

We are a dynamic team of Medicinal Chemists transforming how drugs are designed. By partnering deeply with our AI/ML colleagues, we are doing more than just leveraging the Isomorphic Labs Drug Design Engine – we are actively shaping it. We use our domain expertise to challenge and refine our algorithms, creating a powerful symbiotic relationship that drives our internal and collaborative portfolios.

Your impact

• You will be responsible for line managing and mentoring a small team of talented and high‐performing Medicinal Chemists, fostering their scientific growth and career development.
• You will provide scientific leadership and strategic direction for key drug discovery projects, guiding them from initiation towards clinical candidate selection.
• Working alongside world‐leading AI/ML scientists, you will play a critical role in driving project success, enhancing our AI platform through technical expertise.

What You Will Do

• Provide line management for a team of 2–4 Medicinal Chemists. Set clear goals, provide regular feedback, support their professional development, and foster a collaborative and high‐performance team environment.
• Invent new medicines. Rapidly drive drug discovery programmes to value inflection points by deploying knowledge of modern discovery principles and synthetic organic chemistry, taking ownership as either a Medicinal Chemistry Lead or overall Project Lead.
• Collaborate cross‐functionally to support the data‐driven delivery of high‐quality scientific solutions to complex technical problems.
• Represent the company externally, interacting with existing and prospective collaborators and Contract Research Organisations (CROs).
• Provide strategic input and technical direction to our AI/ML platform teams.
• Effectively manage CRO resources and monitor KPIs to maintain delivery.
• Generate intellectual property positions and capture the value derived from IsoLabs' investment.
• Prepare detailed scientific proposals and reports to support new and ongoing programmes.
• Embrace and champion our culture of inclusion and continuous professional development.

Skills And Qualifications

Essential

• PhD in Medicinal Chemistry, Synthetic Organic Chemistry, or related technical field; or equivalent industrial experience.
• 8+ years' professional experience in a Medicinal Chemistry role, operating within a biotech or pharma setting.
• Proven track record of leading medicinal chemistry efforts on drug discovery projects, demonstrating significant contributions from hit identification through to lead optimisation or candidate nomination, with familiarity of DMPK optimisation.
• Experience contributing to structure‐based drug design problems.
• Experience leading a high‐performing scientific team, mentoring and empowering them to thrive in their roles.
• Excellent strategic thinking, problem‐solving and decision‐making capabilities applied to complex drug discovery challenges.
• Experience working with and closely managing CRO resources.
• Strong track record of scientific achievements, evidenced by publications, patents, and presentations.
• Genuine passion for drug discovery and enthusiasm for the potential of AI/ML to transform the field.
• Excellent communication (written and verbal) and interpersonal skills, with ability to work effectively in a cross‐functional, collaborative team environment.
• Track record of creative problem solving with a strong growth mindset, adaptability, and eagerness to learn new concepts and techniques.

Nice to have

• Experience of successful application of fragment‐based drug design approaches.

Culture and values

• Thoughtful: Thoughtful at Iso is about curiosity, creativity and care. It is about good people doing good, rigorous and future‐making science every single day.
• Brave: Brave at Iso is about fearlessness, but it's also about initiative and integrity. The scale of the challenge demands nothing less.
• Determined: Determined at Iso is the way we pursue our goal. It's a confidence in our hypothesis, as well as the urgency and agility needed to deliver on it. Because disease won't wait, so neither should we.
• Together: Together at Iso is about connection, collaboration across fields and catalytic relationships. It's knowing that transformation is a group project, and remembering that what we're doing will have a real impact on real people everywhere.

Creating An Extraordinary Company

We believe that to be successful we need a team with a range of skills and talents. We're building an environment where collaboration is fundamental, learning is shared and every employee feels supported and able to thrive. We value unique experiences, knowledge, backgrounds, and perspectives, and harness these qualities to create extraordinary impact.

We are committed to equal employment opportunities regardless of sex, race, religion or belief, ethnic or national origin, disability, age, citizenship, marital, domestic or civil partnership status, sexual orientation, gender identity, pregnancy or related condition (including breastfeeding) or any other basis protected by applicable law. If you have a disability or additional need that requires accommodation, please do not hesitate to let us know.

Hybrid working

It's hugely important for us to share knowledge and build strong relationships with each other, and we find it easier to do this if we spend time together in person. This is why we follow a hybrid model, and would require you to be able to come into the office 3 days a week (currently Tuesday, Wednesday, and one other day depending on which team you're in). If you have additional needs that would prevent you from following this hybrid approach, we'd be happy to talk through these if you're selected for an initial screening call.