Senior Scientist / Research Scientist (Biologics), London

Isomorphic Labs is applying frontier AI to help unlock deeper scientific insights, faster breakthroughs, and life‑changing medicines with an ambition to solve all disease. The future is coming, enabled and enriched by the incredible power of machine learning, where diseases are curtailed or cured starting with better and faster drug discovery. Join an interdisciplinary team driving groundbreaking innovation and play a meaningful role in contributing towards achieving our ambitious goals while being part of an inspiring and collaborative culture.

About Iso

Isomorphic Labs (IsoLabs) was launched in 2021 to advance human health by building on and beyond the Nobel‑winning AlphaFold system. Our interdisciplinary team of drug discovery experts and machine learning specialists has built powerful new predictive and generative AI models that accelerate scientific discovery at digital speed. Our name reflects the belief that there is an underlying symmetry between biology and information science. By harnessing AI's capabilities, we can model complex biological phenomena to help design novel molecules, anticipate how drugs will perform, and develop innovative medicines to treat and cure some of the world’s most devastating diseases.

Your Impact

We’re seeking a Senior Scientist / Research Scientist specialising in biologics to contribute to the design of novel large‑molecule therapeutics harnessing the transformative power of our cutting‑edge AI drug design engine. This role requires a unique blend of scientific expertise and the intellectual curiosity to explore uncharted territory in therapeutic design.

• De Novo Biologics Design: Independently lead the hands‑on design optimisation and rigorous experimental validation of novel large‑molecule therapeutics taking concepts from initial idea to well‑characterised lead molecules.
• Drive Project Milestones: Serve as the technical expert for assigned projects coordinating complex internal workstreams and managing external collaborations/CROs to efficiently progress candidates towards critical go/no‑go decisions.
• Platform Implementation: Drive the practical application and implementation of cutting‑edge generative AI and ML tools within drug design workflows to propose, evaluate, and prioritise novel therapeutic concepts.
• Collaboration: Cultivate productive relationships with interdisciplinary teams (ML, Biology, Chemistry) and external partners fostering seamless collaboration to deliver high‑quality data‑driven scientific solutions that drive breakthroughs.
• Advance Experiments: Guide the technical evolution of experimental designs and protocols fostering a culture of scientific excellence.

Essential Skills and Qualifications

• PhD in Immunology, Molecular Biology, Biochemistry or a related scientific discipline.
• 3 years professional experience in an industry role operating within a biotech or pharma setting.
• Strong scientific expertise and hands‑on experience in antibody discovery, engineering, and optimisation strategies including proficiency with multispecifics and antibody drug conjugates (ADCs).
• In‑depth understanding of protein structure‑function relationships and extensive experience applying de‑novo design or advanced protein engineering principles (e.g. affinity maturation, liability de‑risking, developability assessment).
• Genuine passion and enthusiasm for applying AI/ML to drug design and how this can transform the field.
• Excellent communication (written and verbal) and interpersonal skills with an ability to work effectively in a cross‑functional collaborative team environment.
• Track record of creative problem‑solving of some of the most difficult problems in drug discovery with a strong growth mindset, adaptability, and eagerness to learn new concepts and techniques.

Nice to Have

• Demonstrated proficiency in fostering and managing external collaborations with Contract Research Organizations (CROs).
• Experience within immunology and/or oncology therapeutic areas specifically within the realm of biologics discovery.
• Experience leveraging machine learning or computational biology techniques for biologics design and optimisation.

Culture and values

We are guided by our shared values. It’s not about finding people who think and act in the same way. These values help to guide our work and will continue to strengthen it.

• Thoughtful: Curiosity, creativity, and care. Good people doing good, rigorous and future‑making science every single day.
• Brave: Fearlessness, initiative, and integrity. The scale of the challenge demands nothing less.
• Determined: Confidence in our hypothesis as well as the urgency and agility needed to deliver on it.
• Together: Connection, collaboration across fields, and catalytic relationships. Transformation is a group project.

Creating an extraordinary company

We believe that to be successful we need a team with a range of skills and talents. We’re building an environment where collaboration is fundamental, learning is shared, and every employee feels supported and able to thrive. We value unique experiences, knowledge, backgrounds, and perspectives and harness these qualities to create extraordinary impact.

We are committed to equal employment opportunities regardless of sex, race, religion or belief, ethnic or national origin, disability, age, citizenship, marital, domestic or civil partnership status, sexual orientation, gender identity, pregnancy or related condition (including breastfeeding) or any other basis protected by applicable law.

Hybrid working

It’s hugely important for us to share knowledge and build strong relationships with each other, which is why we follow a hybrid model requiring you to come into the office 3 days a week (currently Tuesday, Wednesday, and one other day depending on your team). If you have additional needs that would prevent you from following this hybrid approach, we would be happy to discuss these if you’re selected for an initial screening call.