Senior / Research Scientist (In-vitro / Cellular Pharmacology - Peptides), London

Isomorphic Labs is applying frontier AI to help unlock deeper scientific insights, faster breakthroughs, and life-changing medicines with an ambition to solve all disease. The future is coming—a future enabled by machine learning and a future in which diseases are curtailed or cured starting with better and faster drug discovery. Join an interdisciplinary team driving groundbreaking innovation and contribute toward ambitious goals within an inspiring and collaborative culture.

Isomorphic Labs (IsoLabs) was launched in 2021 to advance human health by building on and beyond the Nobel-winning AlphaFold system. Our interdisciplinary team of drug discovery experts and machine learning specialists has built powerful new predictive and generative AI models that accelerate scientific discovery at digital speed. By harnessing AI's powerful capabilities, we model complex biological phenomena to help design novel molecules, anticipate how drugs will perform and develop innovative medicines to treat and cure some of the world's most devastating diseases.

Join our expanding Exploratory Sciences team, focused on tackling proteins which are critical for disease biology but traditionally considered intractable. We work at the interface of machine learning, chemical biology and drug discovery to apply our platform to some of the toughest problems in drug discovery, collaborating closely with multiple teams across IsoLabs. We have a strong growth mindset and prioritise continued development and learning as we hope to build the next generation of drug discovery scientists. We are expanding our multi-disciplinary Peptides team within Exploratory Sciences, recruiting talented scientists to drive projects toward the clinic. This role is for an In-vitro / Cellular Pharmacologist specialising in peptides, within the Exploratory Sciences Biology team.

This role is ideal for experienced In-vitro / Cellular Pharmacologists with significant working knowledge of biophysical, biochemical and/or cell-based functional assays, and extensive experience providing quantitative in-vitro pharmacology expertise, especially within peptide-based drug discovery projects. You will deliver the development and application of a state-of-the-art peptide design platform, applying our platform in novel ways and driving portfolio projects toward the clinic. You will design and execute bold strategies to tackle problems that are currently considered impossible.

Ready to elevate your scientific career? IsoLabs offers a unique environment to tackle stimulating challenges, push your boundaries and accelerate personal and professional growth. If you are a skilled and ambitious scientist looking to take the next step in your career, joining Isomorphic Labs will challenge you with novel problems and provide an opportunity for professional growth and development.

What You Will Do

• Design efficient and comprehensive biological screening cascades for internal and partnered peptide drug design programs.
• Work with CROs to design decision-making experiments, and deliver high-quality biological data to inform the path to the clinic.
• Collaborate internally and with third-party organisations, interacting with multidisciplinary teams to support data-driven delivery of high-quality scientific solutions.
• Represent the company externally, engaging with existing and prospective collaborators and contract research organisations (CROs).
• Prepare detailed scientific proposals and reports to support new and ongoing programs.
• Embrace and champion our culture of inclusion and continuous professional development.

Skills And Qualifications (Essential)

• PhD, MSc or BSc in Biology or a related technical field, or equivalent industrial experience.
• 3+ years professional experience in a Biology role, in biotech/pharma or a Post Doc position.
• Experience designing and implementing biological screening cascades applied to drug design projects, from hit identification to candidate selection.
• Experience characterising peptide molecules for drug discovery applications.
• Working knowledge of experimental in-vitro pharmacology techniques including biophysical, biochemical and/or cellular assays.
• Experience working with CROs to acquire and interpret high-quality biological data in a timely manner.
• Dynamic, agile, and flexible approach with ability to work across multiple projects and therapeutic areas.
• Excellent communication (written and verbal) and interpersonal skills, with ability to work effectively in a cross-functional, collaborative team environment.
• Track record of creative problem solving with a growth mindset, adaptability, and eagerness to learn new concepts and techniques.

Nice to have

• Experience leading biology within drug discovery programs, ideally from inception to clinical candidate delivery.
• Structural biology and/or display-based techniques for peptide HitID.
• Experience working with Data Science groups on ingesting biological data.
• Track record contributing to drug design projects delivering Clinical Candidates.
• General knowledge of machine learning modelling applied to biological systems and drug discovery.
• Experience of target identification, validation and selection approaches.
• Track record of authorship of relevant scientific manuscripts.
• Experience coding in Python, or willingness to learn in role.

Culture and values

We are guided by our shared values. These values help guide our work and strengthen it.

• Thoughtful — curiosity, creativity and care; good people doing good, rigorous science every day.
• Brave — fearlessness, initiative and integrity; the scale of the challenge demands nothing less.
• Determined — pursuing our goal with confidence in our hypothesis, urgency and agility.
• Together — collaboration across fields and catalytic relationships to create real impact.
• Creating An Extraordinary Company — we value collaboration, learning, and the diverse experiences that create extraordinary impact.

We are committed to equal employment opportunities regardless of protected characteristics.

Hybrid working

We follow a hybrid model and expect to come into the office 3 days a week (currently Tuesday, Wednesday, and one other day depending on team). If you have additional needs that would prevent this, we can discuss them during the screening process.

Please note that when you submit an application, your data will be processed in line with our privacy policy.