Senior Research Investigator, (Biologics Pharmacology), London

Isomorphic Labs is applying frontier AI to help unlock deeper scientific insights, faster breakthroughs, and life-changing medicines with an ambition to solve all disease. The future is coming, enabled and enriched by the incredible power of machine learning, where diseases are curtailed or cured starting with better and faster drug discovery.

About Iso

Isomorphic Labs (IsoLabs) was launched in 2021 to advance human health by building on and beyond the Nobel-winning AlphaFold system. Our interdisciplinary team of drug discovery experts and machine learning specialists has built powerful new predictive and generative AI models that accelerate scientific discovery at digital speed. Our name comes from the belief that there is an underlying symmetry between biology and information science. By harnessing AI’s powerful capabilities, we can model complex biological phenomena to help design novel molecules, anticipate how drugs will perform, and develop innovative medicines to treat and cure some of the world’s most devastating diseases.

Your Impact

We’re seeking a Senior Research Investigator specialising in biologics drug development to contribute to the pharmacology and translational biology strategy of our novel large molecule therapeutics, harnessing the transformative power of our cutting-edge AI drug design engine. This role requires a unique blend of scientific expertise and the intellectual curiosity to explore uncharted territory in therapeutic design.

What You Will Do

• Translational Biology Strategy: Design, execute, and oversee comprehensive pharmacology plans for our large molecule therapeutics.
• In Vivo & In Vitro Evaluation: Lead the design and execution of in vivo efficacy and complex in vitro functional assays to ensure high-quality data generation.
• Drive Project Milestones: Act as the Biology Lead for assigned projects, coordinating complex internal workflows and external CROs to efficiently progress candidates toward critical go/no-go decisions and program milestones.
• New Target Identification: Collaborate with computational biology and design teams to identify, evaluate, and bring new biologics projects into the portfolio, assessing biological feasibility and therapeutic potential.
• Collaborative Platform Building: Partner closely with interdisciplinary teams (ML, Biology, CompBio) to help build our generative AI platform, ensuring the pharmacology data you generate is effectively fed back into design loops.

Essential Skills and Qualifications:

• PhD in Immunology, Cancer Biology, Molecular Biology, Biochemistry, Pharmacology or a related scientific discipline.
• 5+ years’ professional experience in an industry role within a biotech or pharma setting.
• A strong scientific expertise in, and in-depth understanding of, disease models and their use in biologics drug development.
• Significant experience in the design and execution of studies to support project progression in the field of biologics drug discovery and development.
• Experience within the immunology, inflammation or oncology therapeutic areas.
• A proficiency with modalities such as multi-specifics or antibody drug conjugates (ADCs).
• Demonstrated proficiency in fostering and managing external collaborations with Contract Research Organizations (CROs) and world-leading academic groups.
• Excellent communication (written and verbal) and interpersonal skills, with a proven ability to work effectively in a cross-functional, collaborative team environment.

Culture and values

We are guided by our shared values. It's not about finding people who think and act in the same way. These values help to guide our work and will continue to strengthen it.

• Thoughtful: Curiosity, creativity and care.
• Brave: Fearlessness, initiative and integrity.
• Determined: Confidence in our hypothesis, urgency and agility needed to deliver on it.
• Together: Connection, collaboration across fields and catalytic relationships.

Creating an extraordinary company

We believe that to be successful we need a team with a range of skills and talents. We're building an environment where collaboration is fundamental, learning is shared and every employee feels supported and able to thrive. We value unique experiences, knowledge, backgrounds, and perspectives, and harness these qualities to create extraordinary impact.

Hybrid working

It’s hugely important for us to share knowledge and build strong relationships with each other, and we find it easier to do this if we spend time together in person. This is why we follow a hybrid model, and would require you to be able to come into the office 3 days a week.