Research Lead (Formulation Sciences), London London

Isomorphic Labs is applying frontier AI to help unlock deeper scientific insights, faster breakthroughs, and life-changing medicines with an ambition to solve all disease. The future is coming. A future enabled and enriched by the incredible power of machine learning. A future in which diseases are curtailed or cured starting with better and faster drug discovery. Come and be part of an interdisciplinary team driving groundbreaking innovation and play a meaningful role in contributing towards us achieving our ambitious goals, while being a part of an inspiring and collaborative culture.

About Iso

Isomorphic Labs (IsoLabs) was launched in 2021 to advance human health by building on and beyond the Nobel-winning AlphaFold system. Since then, our interdisciplinary team of drug discovery experts and machine learning specialists has built powerful new predictive and generative AI models that accelerate scientific discovery at digital speed. Our name comes from the belief that there is an underlying symmetry between biology and information science. By harnessing AI’s powerful capabilities, we can use it to model complex biological phenomena to help design novel molecules, anticipate how drugs will perform and develop innovative medicines to treat and cure some of the world’s most devastating diseases.

Your impact

As part of the ongoing expansion of our Drug Design and Medical Research function (DDMR), we are looking to recruit a Formulation expert keen to impact drug discovery projects. You will be supporting the business alongside world leading AI/ML Drug Design Platform teams. You will collaborate to deliver scientific expertise and strategic direction to drive both improvements in the Platform and apply this to real drug design projects. As a member of the DPC and Preclinical formulation team, you will be responsible for supporting the rapid progression of multiple drug discovery/DPC and preclinical development projects by providing (pre)-formulation expertise to the program team leveraging significant external CRO resources.

What you will do

• Develop and execute comprehensive (pre)-formulation strategies for small molecules across the drug discovery and preclinical development lifecycle working closely with the drug design, pre-clinical and CMC function.
• Design and refine innovative formulation technologies, such as solid dispersions and co-crystals, to optimise solubility, stability, and manufacturability.
• Develop and interpret stability studies utilising ICH and ASAP methodologies, while implementing rigorous in-process controls to ensure product performance.
• Collaborate across multi-disciplinary preclinical teams to deliver seamless and integrated solutions.
• Author technical reports, protocols, and regulatory submissions in strict alignment with internal policies and global regulatory requirements.

Skills and qualifications

• PhD in pharmaceutical science, or a related technical field, or equivalent experience.
• 6+ years of professional experience within a biotech or pharma setting.
• Demonstrated expertise in the development of oral solid dosage forms.
• Demonstrated experience of supporting IND packages.
• Deep technical proficiency in preformulation, manufacturing processes, and the implementation of advanced drug delivery technologies.
• Rigorous understanding of global regulatory guidelines, including ICH and FDA.
• Excellent communication (written and verbal), interpersonal and influencing skills, with an ability to work effectively in a cross-functional, collaborative team environment.

Nice to have

• Specialised knowledge and practical experience in the development of amorphous dispersions is highly advantageous.

Culture and values

We are guided by our shared values. It's not about finding people who think and act in the same way. These values help to guide our work and will continue to strengthen it.

• Thoughtful: Thoughtful at Iso is about curiosity, creativity and care. It is about good people doing good, rigorous and future-making science every single day.
• Brave: Brave at Iso is about fearlessness, but it’s also about initiative and integrity. The scale of the challenge demands nothing less.
• Determined: Determined at Iso is the way we pursue our goal. It’s a confidence in our hypothesis, as well as the urgency and agility needed to deliver on it.
• Together: Together at Iso is about connection, collaboration across fields and catalytic relationships.

Creating an extraordinary company

We believe that to be successful we need a team with a range of skills and talents. We're building an environment where collaboration is fundamental, learning is shared and every employee feels supported and able to thrive. We value unique experiences, knowledge, backgrounds, and perspectives, and harness these qualities to create extraordinary impact.

We are committed to equal employment opportunities regardless of sex, race, religion or belief, ethnic or national origin, disability, age, citizenship, marital, domestic or civil partnership status, sexual orientation, gender identity, pregnancy or related condition (including breastfeeding) or any other basis protected by applicable law.

If you have a disability or additional need that requires accommodation, please do not hesitate to let us know. It’s hugely important for us to share knowledge and build strong relationships with each other, and we find it easier to do this if we spend time together in person. This is why we follow a hybrid model, and would require you to be able to come into the office 3 days a week (currently Tuesday, Wednesday, and one other day depending on which team you’re in).