Chemistry Lead (Induced Proximity), London

Isomorphic Labs is applying frontier AI to help unlock deeper scientific insights, faster breakthroughs, and life-changing medicines with an ambition to solve all disease. The future is coming, enabled and enriched by the incredible power of machine learning, where diseases are curtailed or cured starting with better and faster drug discovery.

About Iso

Isomorphic Labs (IsoLabs) was launched in 2021 to advance human health by building on and beyond the Nobel-winning AlphaFold system. Our interdisciplinary team of drug discovery experts and machine learning specialists has built powerful new predictive and generative AI models that accelerate scientific discovery at digital speed. Our name comes from the belief that there is an underlying symmetry between biology and information science. By harnessing AI’s powerful capabilities, we can model complex biological phenomena to help design novel molecules, anticipate how drugs will perform, and develop innovative medicines to treat and cure some of the world’s most devastating diseases.

About The Exploratory Sciences Team

Join our expanding Exploratory Sciences team, focused on tackling proteins critical for disease biology, traditionally considered intractable. We are a small, multidisciplinary team within the Drug Design and Medical Research function at Isomorphic Labs, working at the interface of machine learning, chemical biology, and drug discovery. We collaborate closely with multiple teams across Isomorphic Labs and prioritise continued development and learning to build the next generation of drug discovery scientists.

Your impact

As a member of the Induced Proximity team, you will deliver the development and application of a state-of-the-art induced proximity design platform, applying it in novel ways and driving portfolio projects towards the clinic. You will need to design and execute bold strategies to tackle problems currently considered impossible, collaborating with world-leading AI/ML and Drug Design Platform teams.

Ready to elevate your scientific career? Isomorphic Labs offers ambitious scientists a unique environment to tackle stimulating challenges, pushing your boundaries and accelerating your personal and professional growth.

What You Will Do

• Apply your knowledge of cutting-edge molecular glue design and synthesis to tackle long-standing challenges in drug discovery.
• Utilise internal AI/ML models to solve challenging drug discovery problems.
• Collaborate internally and with third-party organisations, interacting within multidisciplinary teams to support data-driven delivery of high-quality scientific solutions.
• Represent the company externally, interacting with existing and prospective collaborators and contract research organisations (CROs).
• Prepare detailed scientific proposals and reports to support new and ongoing programs.
• Embrace and champion our culture of inclusion and continuous professional development.

Skills And Qualifications

• PhD in Chemistry, or a related technical field, or equivalent experience.
• 3+ years professional experience in a Chemistry role, either in a biotech or pharma setting, or within a Post Doc position.
• Practical experience in the design and synthesis of chemical inducers of proximity/molecular glues, ideally with experience of applying these skills to active drug discovery projects.
• Broad knowledge of current chemical biology techniques.
• Experience of coding in Python, or a willingness to learn in-role.
• A genuine passion and enthusiasm for applying AI/ML to drug design.
• Excellent communication (written and verbal) and interpersonal skills, with an ability to work effectively in a cross-functional, collaborative team environment.
• A track record of creative problem solving with a strong growth mindset, adaptability, and eagerness to learn new concepts and techniques.

• Experience working with or managing activities at contract research organisations (CROs).
• Experience of contributing to structure-based drug design (SBDD) problems.
• Experience of applying ML methods to Drug Discovery problems.
• Track record of authorship of relevant scientific manuscripts.

Culture and values

We are guided by our shared values. It’s not about finding people who think and act in the same way. These values help to guide our work and will continue to strengthen it.

• Thoughtful: Curiosity, creativity, and care in rigorous and future-making science.
• Brave: Fearlessness, initiative, and integrity in facing challenges.
• Determined: Confidence in our hypothesis and urgency to deliver on it.
• Together: Connection and collaboration across fields for impactful transformation.

Creating An Extraordinary Company

We believe that to be successful we need a team with a range of skills and talents. We’re building an environment where collaboration is fundamental, learning is shared, and every employee feels supported and able to thrive. We value unique experiences, knowledge, backgrounds, and perspectives, and harness these qualities to create extraordinary impact.

We are committed to equal employment opportunities regardless of sex, race, religion or belief, ethnic or national origin, disability, age, citizenship, marital status, sexual orientation, gender identity, pregnancy or related condition, or any other basis protected by applicable law.

Hybrid working

It’s important for us to share knowledge and build strong relationships, which is why we follow a hybrid model, requiring you to come into the office 3 days a week. If you have additional needs that would prevent you from following this hybrid approach, we’d be happy to discuss these if selected for an initial screening call.