Synthetic Chemistry Lead, London London

About Iso

Isomorphic Labs (IsoLabs) was launched in 2021 to advance human health by building on and beyond the Nobel‑winning AlphaFold system. Since then, our interdisciplinary team of drug discovery experts and machine learning specialists has built powerful new predictive and generative AI models that accelerate scientific discovery at digital speed. Our name comes from the belief that there is an underlying symmetry between biology and information science. By harnessing AI’s powerful capabilities, we can model complex biological phenomena to design novel molecules, anticipate how drugs will perform and develop innovative medicines to treat and cure some of the world’s most devastating diseases. We have built a world‑leading drug design engine comprising AI models that are capable of working across multiple therapeutic areas and drug modalities. We are continually innovating on model architecture and developing cutting‑edge capabilities to advance rational drug design. Every day, and with each new breakthrough, we’re getting closer to the promise of digital biology, and achieving our ambitious mission to one day solve all disease with the help of AI.

About the Synthetic Chemistry, CMC and Logistics team

Our dynamic team of Synthetic Chemists and CRO Leads are dedicated to transforming drug design and manufacturing. We work in partnership with our AI/ML and drug discovery colleagues to support all phases of chemistry, from early to late stages, as well as managing our extensive external CRO team. We promote a supportive atmosphere where the diverse expertise of every team member is recognised and appreciated. We maintain a strong growth mindset, with continuous development and learning as a priority.

Your impact

As part of the ongoing expansion of our Drug Design and Medical Research function, we are hiring Synthetic Chemists who are keen to impact medicinal chemistry projects and/or CMC projects. You will support the business alongside world‑leading AI/ML Drug Design Platform teams. You will deliver scientific expertise and strategic direction to drive improvements in the Platform and the advancement of active drug discovery programs.

What you will do

• Apply your Synthetic Chemistry expertise across Medicinal Chemistry and/or CMC projects.
• Act as a Synthetic Chemistry Lead in one or more active drug discovery programs.
• Collaborate both internally and with third‑party organisations, interacting within multidisciplinary teams to support the data‑driven delivery of high‑quality scientific solutions to complex technical problems.
• Work cross‑functionally with the Medicinal Chemistry, DMPK, Biology, and Technology teams.
• Represent the company externally, interacting with existing and prospective collaborators including Contract Research Organisations (CROs) and Contract Development & Manufacturing Organisations (CDMOs).
• Prepare detailed scientific proposals and reports to support new and ongoing programs.
• Embrace and champion our culture of inclusion and continuous professional development.

Skills and qualifications

• PhD in Synthetic Chemistry, or a related technical field, or equivalent industrial experience.
• 3+ years’ professional experience in a Chemistry role, operating within a biotech, pharma or CRO setting. 5+ years' experience for more senior positions.
• Solid technical foundation in synthetic chemistry with previous experience operating independently as an individual contributor.
• Excellent problem‑solving and decision‑making capabilities applied to complex synthetic chemistry challenges.
• Experience of working with and closely managing CRO and/or CDMO resources.
• A genuine passion for drug discovery and enthusiasm for the potential of AI/ML to transform the field.
• Excellent communication (written and verbal) and interpersonal skills, with an ability to work effectively in a cross‑functional, collaborative team environment.
• Track record of creative problem solving with a strong growth mindset, adaptability, and eagerness to learn new concepts and techniques.

We are committed to equal employment opportunities regardless of sex, race, religion or belief, ethnic or national origin, disability, age, citizenship, marital, domestic or civil partnership status, sexual orientation, gender identity, pregnancy or related condition (including breastfeeding) or any other basis protected by applicable law. If you have a disability or additional need that requires accommodation, please do not hesitate to let us know.

It’s hugely important for us to share knowledge and build strong relationships with each other, and we find it easier to do this if we spend time together in person. This is why we follow a hybrid model, and would require you to be able to come into the office 3 days a week (currently Tuesday, Wednesday, and one other day depending on which team you’re in). If you have additional needs that would prevent you from following this hybrid approach, we’d be happy to talk through these if you’re selected for an initial screening call.