At a Glance
- Tasks: Lead innovative biomarker strategies in clinical development for oncology and rare diseases.
- Company: Join Ipsen, a global biopharmaceutical leader focused on transformative medicines.
- Benefits: Enjoy competitive salary, health benefits, and opportunities for professional growth.
- Other info: Dynamic work environment with a focus on innovation and teamwork.
- Why this job: Make a real impact on patient lives through cutting-edge research and collaboration.
- Qualifications: PhD in relevant field with experience in biomarker activities and clinical studies.
The predicted salary is between 80000 - 90000 £ per year.
About Ipsen: Ipsen is a mid-sized global biopharmaceutical company with a focus on transformative medicines in three therapeutic areas: Oncology, Rare Disease and Neuroscience. Supported by nearly 100 years of development experience, with global hubs in the U.S., France and the U.K, we tackle areas of high unmet medical need through research and innovation. Our passionate teams in more than 40 countries are focused on what matters and endeavour every day to bring medicines to patients in 88 countries. We build a workplace that champions human-centric leadership and fosters a culture of collaboration, excellence and impact. At Ipsen, every individual is empowered to be their true selves, grow and thrive alongside the company's success. Join us on our journey towards sustainable growth, creating real impact on patients and society!
Job Description:
To develop and lead clinical biomarker strategies that enable data-driven decision-making across clinical development and maximise the value of Ipsen's oncology and rare disease portfolio. The Biomarker Lead serves as a strategic partner to cross-functional development teams, ensuring biomarker approaches are scientifically robust, aligned with program objectives, and support critical development milestones.
Main Responsibilities & Technical Competencies:
- Develop and lead clinical biomarker strategies across Ipsen's oncology and rare disease portfolio to support critical development and portfolio decisions.
- Define biomarker plans to support target engagement, pharmacodynamic and mechanistic understanding, patient stratification, and support efficacy assessment across clinical development.
- Provide strategic leadership for biomarker data generation from early clinical development through late-stage and registration-enabling studies, as appropriate.
- Select and apply the most appropriate biomarker technologies and analytical approaches to address program objectives, including cellular, tissue-based, genomic, transcriptomic, proteomic, and emerging platform technologies.
- Drive implementation of biomarker strategies within clinical studies, including development of protocols, schedules of activities, laboratory manuals, biomarker analysis plans, and study-related documentation.
- Provide scientific oversight of biomarker assay development, fit-for-purpose validation, and analytical performance assessments to ensure data quality and fitness for intended use.
- Collaborate with Clinical Development, Translational Pharmacology, Companion Diagnostics, Clinical Pharmacology, Biostatistics, Clinical Operations, Regulatory Affairs, and external partners to ensure successful execution and interpretation of biomarker activities.
- Lead the selection, oversight, and performance management of external laboratories, CROs, and other vendors supporting biomarker development and analysis.
- Contribute to biomarker components of statistical analysis plans and integrate biomarker findings into study interpretation and development strategy.
- Author, review, and contribute to biomarker sections of protocols, study reports, regulatory submissions, briefing documents, and health authority responses.
- Represent Biomarkers on cross-functional project teams and governance forums, effectively communicating biomarker strategies, risks, opportunities, and key findings.
- Manage biomarker budgets, contracts, timelines, and outsourcing activities in accordance with Ipsen processes and standards.
- Maintain current knowledge of emerging biomarker science, diagnostic technologies, and global regulatory expectations relevant to biomarker and precision medicine development.
- Ensure compliance with applicable regulations, industry standards, Good Clinical Practice (GCP), Good Laboratory Practice (GLP), and Ipsen SOPs.
Behavioural Competencies Required:
- Communicates Effectively - Translates complex scientific concepts into clear, impactful messages tailored to diverse audiences, from technical experts to senior leaders and non-scientific stakeholders.
- Influences - Builds alignment and gains commitment across cross-functional teams and external partners to advance biomarker strategies and achieve program objectives.
- Manage Complexity - Evaluates scientific opportunities and competing priorities critically, focusing efforts on biomarker approaches that generate meaningful evidence and support decision-making.
- Adaptability - Remains effective and resilient in a rapidly changing environment, adjusting priorities and approaches in response to evolving program and portfolio needs.
- Collaborates - Builds productive relationships across functions, fosters an inclusive and supportive team environment, and leverages diverse expertise to achieve shared goals.
Knowledge & Experience:
- Experience supporting biomarker activities across clinical development, including design and implementation of biomarker plans within clinical studies.
- Strong understanding of translational science and the role of biomarkers in informing target engagement, pharmacodynamic activity, mechanism of action, patient stratification, efficacy, and safety.
- Experience applying a range of biomarker technologies and platforms, including tissue-based, cellular, genomic, transcriptomic and proteomic approaches.
- Knowledge of biomarker assay development, fit-for-purpose validation, analytical performance assessment, and data quality requirements for clinical studies.
- Strong scientific problem-solving skills, with the ability to critically evaluate opportunities, risks, and evidence to support practical, decision-focused biomarker strategies.
- Excellent written, verbal, and presentation skills, with the ability to communicate complex scientific concepts effectively to both technical and non-technical audiences.
- Experience in oncology and/or rare disease drug development is strongly preferred.
Education / Certifications (essential):
- PhD in Immunology, Oncology, Life Sciences, or a related scientific discipline. Equivalent combinations of education, scientific training, and relevant industry experience may be considered.
Language(s) (essential):
- English: Business level, oral and written
Senior Principal Scientist employer: Ipsen Group
Ipsen Group in Wrexham is an excellent employer that prioritises employee growth and development within the pharmaceutical manufacturing sector. With a strong commitment to innovation and excellence, employees benefit from a collaborative work culture that values safety and compliance, alongside opportunities for meaningful contributions to drug substance production. The location offers a supportive environment where team members can thrive and make a real impact in their roles.
StudySmarter Expert Advice🤫
We think this is how you could land Senior Principal Scientist
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We think you need these skills to ace Senior Principal Scientist
Some tips for your application 🫡
Show Off Your Lab Skills:In the biotechnology field, it's super important to highlight your lab experience in your CV. Be sure to mention specific techniques or instruments you've mastered (think PCR, gel electrophoresis, etc.) and any relevant projects you've worked on. This will show Ipsen Group that you have the hands-on skills they need.
Tailor Your Technical Skills:Make sure to emphasise your technical skills, especially those relevant to the biotechnology sector. Include any software tools or programming languages you've used, like R or Python for data analysis, which could be key for this role at Ipsen Group.
Craft a Compelling Cover Letter:Since this is a full-time role, your cover letter should reflect not only your passion for biotechnology but also your long-term career ambitions. Share why you're excited about the work that Ipsen Group does and how you envision contributing to their goals. This shows that you’re not just looking for any job, but you're genuinely invested in this opportunity.
Include Your Papers and Projects:If you've published any papers or contributed to significant projects, mention them! These documents can boost your application and provide tangible evidence of your expertise in the biotechnology field. Don’t forget to link to any relevant publications or project summaries—this can set you apart from other candidates.
How to prepare for a job interview at Ipsen Group
✨Brush Up on Lab Techniques
Since you're eyeing a full-time gig in biotechnology, make sure you're well-versed in the lab techniques relevant to the role. Be ready to talk about PCR, CRISPR, or any specific methods mentioned in the job description at Ipsen Group. You might even be asked to demonstrate your understanding of these processes.
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Get comfortable with bioinformatics tools that are commonly used in the industry, like BLAST or Bioconductor. These are key in biotechnology, and having hands-on experience or at least familiarity can set you apart. Prepare to discuss any relevant projects you've worked on, especially if they involved data analysis or genomic research.
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✨Research Recent Biotech Innovations
Stay updated on the latest trends and breakthroughs in biotechnology. Knowing what's happening in the field can help you engage in more meaningful discussions during your interview. Bring up recent articles or advancements that excite you, especially those related to the work being done at Ipsen Group. This shows your passion for the industry!
