At a Glance
- Tasks: Discover and optimise novel ligands for targeted protein degradation using cutting-edge technologies.
- Company: University of Bath, part of a prestigious biosciences partnership.
- Benefits: Gain hands-on experience, extensive training, and collaborate with leading experts.
- Other info: Dynamic research environment with excellent career prospects in bioscience.
- Why this job: Make a real impact in drug discovery and contribute to groundbreaking research.
- Qualifications: Passion for science, relevant degree, and strong maths background required.
The predicted salary is between 19350 - 23650 £ per year.
University of Bath, United Kingdom
Application deadline: 02 Aug 2026
About The Project
This project is one of a number that are in competition for funding from the South West Biosciences Doctoral Training Partnership (SWBio DTP). The SWBio DTP is funded by BBSRC and involves a partnership of world-renowned universities, research institutes and industry, based mainly across the South West and Wales. This partnership has established international, national and regional scientific networks, and widely recognised research excellence and facilities. Studentships are available for entry in September 2026. First stage interviews will be held during the week commencing August 10th. All SWBio DTP projects will follow a structured training programme to ensure you are well equipped as a bioscience researcher, supporting careers into academia, industry and beyond.
Supervisory Team
- Lead supervisor: Dr Julien Licchesi (University of Bath)
- Co-supervisors: Professor Matthew Crump (University of Bristol), Professor Christiane Berger-Schaffitzel (University of Bristol), Dr Scott Lovell (University of Bath)
The Project
Targeted Protein Degradation (TPD) is transforming modern drug discovery by enabling the selective removal of disease-causing proteins rather than merely inhibiting them. Among TPD strategies, PROteolysis TArgeting Chimeras (PROTACs) have shown remarkable clinical success, particularly in prostate and breast cancers. These bifunctional molecules recruit an E3 ubiquitin ligase to a target protein, triggering ubiquitin-dependent proteasomal degradation. Despite this progress, only a small fraction of the ~600 human E3 ligases are currently used in PROTAC design. Expanding the repertoire of E3 ligases could greatly increase the range of druggable targets and the biological contexts in which PROTACs can be applied. A major challenge, however, is the limited availability of suitable ligands to recruit these underexplored E3 ligases.
Project Aims
This PhD project aims to discover and optimise novel ligands for an underexplored E3 ubiquitin ligase using high-throughput aptamer-SELEX technology. To further broaden the ligand discovery pipeline, complementary screens for affimers, macrocyclic peptides, and covalent ligands will also be undertaken. Ligand binding modes and affinities will be characterised using biophysical and structural biology techniques, including NMR spectroscopy, to guide rational design and optimisation. Promising candidates will be incorporated into next-generation BioPROTAC and PROTAC molecules, which will then be evaluated for target engagement and protein degradation potential in cellular assays using flow cytometry, western blotting, high-content microscopy, HiBiT-NanoLuc, and in vitro biochemical assays.
Training and Methods
This interdisciplinary project provides extensive training in molecular and structural biology, biophysical characterisation, ligand discovery and optimisation, and functional evaluation using cell-based assays. The successful candidate will gain hands-on experience with cutting-edge technologies and benefit from close collaboration with experts in chemical and structural biology, providing a strong foundation for a career in targeted protein degradation research and drug discovery.
Project Keywords: Targeted protein degradation, ubiquitin, chemical biology, PROTAC, Aptamer
Applicant Requirements
We are looking for a self-motivated candidate with genuine passion for scientific discovery. Prior laboratory experience with protein biochemistry, nucleic acid technologies, or biophysical methods would be advantageous. Applicants should have obtained, or be about to obtain, a First or Upper Second Class UK Honours degree, or the equivalent qualifications gained outside the UK, in an appropriate area of science or technology. Applicants with a Lower Second Class degree will be considered if they also have Master's degree awarded with Merit. In addition, due to the strong mathematical component of the taught course in the first year and the quantitative emphasis in our projects, a minimum of a grade B in A-level Maths or an equivalent qualification/experience is required. Physics A-level (grade B and above) or units in your degree with a significant mathematical component, e.g. maths, statistics, bioinformatics. Applicants must ensure they highlight their Maths background within their application and upload any supporting evidence. If English is not your first language, you will need to have achieved Academic IELTS 6.5 overall (with no less than 6.5 in any of the four skills). Find details of other acceptable tests and further information on our website.
Enquiries And Applications
Informal enquiries are welcomed and should be directed to Dr Julien Licchesi: j.licchesi@bath.ac.uk. Applications will close on Sunday August 2nd.
SWBio DTP PhD Project: Rational Design of Novel Degraders for Targeted Protein Degradation employer: Instruct-ERIC
The University of Oxford is an exceptional employer, offering a vibrant and collaborative work culture that fosters innovation and academic excellence. As a Postdoctoral Research Assistant in Structural Biology, you will have access to cutting-edge facilities and resources, alongside opportunities for professional development and networking within a world-renowned institution. Located in the historic city of Oxford, you will enjoy a stimulating environment that encourages both personal and professional growth while contributing to groundbreaking research in bacterial membrane biology.
StudySmarter Expert Advice🤫
We think this is how you could land SWBio DTP PhD Project: Rational Design of Novel Degraders for Targeted Protein Degradation
✨Get Your Foot in the Lab Door
Look for internship programmes specifically set up for life sciences or biotechnology students. Many companies, including Instruct-ERIC, offer structured pathways for interns, so check their careers page or your university's career services to snag those early opportunities.
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✨Get Involved in Research Projects
If you haven’t already, volunteer for or participate in research projects at your university. This hands-on experience not only builds your CV but also helps you make connections with faculty who can recommend you or point you to internship opportunities at companies like Instruct-ERIC.
✨Keep Your Application Needs in Mind
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We think you need these skills to ace SWBio DTP PhD Project: Rational Design of Novel Degraders for Targeted Protein Degradation
Some tips for your application 🫡
Highlight Your Lab Skills:For a biotech internship, showcasing any relevant lab skills is crucial. If you've worked with lab techniques like PCR, gel electrophoresis, or CRISPR, make sure these stand out in your CV. We want to see that you have hands-on experience and can contribute from day one.
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How to prepare for a job interview at Instruct-ERIC
✨Brush Up on Lab Techniques
As we're diving into the biotechnology world, it's essential to refresh your knowledge on commonly used lab techniques. Be prepared to discuss methods like PCR, gel electrophoresis, and CRISPR. They might even ask you to explain the principles behind them or how you've used them in your studies!
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Biotechnology often involves collaboration, so emphasising your ability to work in a team is crucial. Think about group projects or lab work where you collaborated with peers. Sharing these experiences will show Instruct-ERIC that you're not only a great individual contributor but also a team player, ready to thrive in their collaborative environment.
