At a Glance
- Tasks: Uncover molecular machinery of sphingolipids in bacteria using advanced techniques.
- Company: Join the prestigious University of Oxford's Sir William Dunn School of Pathology.
- Benefits: Gain invaluable research experience and contribute to groundbreaking discoveries.
- Other info: Fixed-term position with potential for extension and excellent career development.
- Why this job: Make a real impact in bacterial biology and antimicrobial resistance research.
- Qualifications: PhD in structural biology and experience with cryo-EM required.
The predicted salary is between 31500 - 38500 £ per year.
We are seeking an ambitious Postdoctoral Research Assistant to join the laboratory of Dr Georgia Isom at the Sir William Dunn School of Pathology, University of Oxford, to uncover the molecular machinery that transports sphingolipids to the surface of Gram‑negative bacteria. This exciting project combines cryo‑electron microscopy, native mass spectrometry, proteomics, and bacterial cell biology to answer a fundamental question in bacterial membrane biology.
For decades, sphingolipids were thought to be almost exclusively eukaryotic membrane components, with only a handful of unusual bacteria capable of producing them. Our recent discoveries have overturned this view, revealing that sphingolipid biosynthesis is widespread across diverse bacteria. Emerging evidence suggests sphingolipids are key determinants of membrane homeostasis, environmental adaptation, antimicrobial resistance and host‑pathogen interactions. Yet one of the biggest questions in the field remains unanswered: how are sphingolipids transported across the bacterial cell envelope to reach the cell surface?
As the successful candidate, you will drive this project by combining structural and mechanistic approaches to identify and characterise sphingolipid transport systems. You will determine high resolution single particle cryo-EM structures of sphingolipid transporters. In parallel, you will assess sphingolipid‑transporter interactions and the role of the sphingolipids in membrane homeostasis using a combination of mass spectrometry and cellular electron microscopy methods.
The post-holder should hold, or be close to completion of, a PhD in structural biology and have experience of solving high resolution structures using single particle cryo-EM. You should be highly motivated, organised and able to work independently as well as part of a team.
This is a fixed‑term appointment available for 2 years in the first instance (with funds to extend) with the position available from autumn/winter 2026. Interviews will be held soon thereafter.
Informal enquiries could be sent to Dr Georgia Isom via email: georgia.isom@path.ox.ac.uk.
Postdoctoral Research Assistant in Structural Biology employer: Instruct-ERIC
The University of Oxford is an exceptional employer, offering a vibrant and collaborative work culture that fosters innovation and academic excellence. As a Postdoctoral Research Assistant in Structural Biology, you will have access to cutting-edge facilities and resources, alongside opportunities for professional development and networking within a world-renowned institution. Located in the historic city of Oxford, you will enjoy a stimulating environment that encourages both personal and professional growth while contributing to groundbreaking research in bacterial membrane biology.
StudySmarter Expert Advice🤫
We think this is how you could land Postdoctoral Research Assistant in Structural Biology
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We think you need these skills to ace Postdoctoral Research Assistant in Structural Biology
Some tips for your application 🫡
Showcase Relevant Lab Skills:In the biotech world, your lab skills are paramount. Make sure your CV highlights specific techniques and equipment you’ve used, such as PCR, gel electrophoresis, or cell culture. This will give us a clear picture of what you can bring to Instruct-ERIC as a temporary teammate.
Highlight Your Research Experience:If you’ve worked on any research projects — whether during your studies or in previous positions — make sure to detail these in your application. Include the objective, your role, and what you achieved. This will help us see your potential and fit for the temporary position at Instruct-ERIC.
Keep It Concise and Relevant:Especially for a temporary role, we want to see a clear and focused application. Tailor your CV and cover letter to emphasise the qualifications and experiences that are most relevant to the biotech field and the specific role at Instruct-ERIC. This shows us you’re genuinely interested and capable.
Be Clear About Your Availability:Since it’s a temporary role, let us know right away when you’re available to start and how long you can commit. Include this in your cover letter — this kind of transparency saves us all time and helps us find the right fit quickly at Instruct-ERIC.
How to prepare for a job interview at Instruct-ERIC
✨Brush Up on Your Biotech Basics
Understanding the fundamental concepts in biotechnology is crucial. Be ready to discuss core topics like genetics, molecular biology, or bioinformatics, especially if you're asked technical questions. We suggest revisiting your coursework or recent projects to refresh your memory.
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Since this is a temporary role, they’re likely looking for someone who can jump in and get up to speed quickly. Share experiences where you’ve adapted to new environments, tools, or teams in a short space of time. It shows you're ready to tackle the challenge head-on!
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If you’ve got hands-on experience in lab settings, now’s the time to showcase it. Talk about specific techniques you’ve mastered, like PCR or chromatography, and any relevant safety protocols you’ve followed. These details help paint you as an effective team member from day one.
✨Be Prepared to Explain Your Passion
Hiring managers want to see your motivation, especially for a temporary position in a fast-paced field like biotechnology. Be ready to discuss what excites you about the industry, your career goals, and how this role at Instruct-ERIC aligns with them. It’s all about showing that you’re not just looking for a job, but a stepping stone in your biotech journey.
