At a Glance
- Tasks: Join our team to explore host-pathogen interactions using advanced structural biology techniques.
- Company: Be part of the vibrant University of Leicester's AKV lab, a leader in innovative research.
- Benefits: Enjoy a 3-year funded position with access to state-of-the-art facilities and international support.
- Other info: Collaborative environment with opportunities for career growth and networking.
- Why this job: Make a real impact in cutting-edge research while developing your expertise in structural biology.
- Qualifications: PhD in relevant fields and experience in protein structure determination required.
The predicted salary is between 35000 - 45000 £ per year.
The AKV lab (https://www.akv-lab.com/) is seeking to recruit a highly motivated and enthusiastic Postdoc/Research Associate to join our group and contribute to elucidating the molecular mechanisms associated with host-pathogen interactions and DNA-repair complexes. The project will involve extensive use of membrane protein biochemistry and single particle cryo-EM to characterise the dynamic interplay between membrane integrated complexes and DNA-repair complexes in mediating fine modulation of host pathogen interactions.
About us: The AKV-lab is based at the Institute for Structural and Chemical Biology (LISCB) and the Molecular and Cell Biology Division (MCB), University of Leicester, UK. The University offers excellent support for international researchers and fosters a vibrant, multicultural academic community. Our interdisciplinary research environment provides access to state‑of‑the‑art facilities for biochemistry, microbiology, X‑ray crystallography, and cryo‑electron microscopy (cryo‑EM), including an in‑house Titan Krios 300 keV microscope.
The postholder will have the opportunity to develop expertise in membrane protein biochemistry, protein–DNA complex characterisation, cryo‑EM, and complementary biophysical and biochemical methods. You will lead an independent research project, progressing from initial cloning to the purification of membrane protein complexes, followed by structure determination and biochemical/biophysical mechanistic analysis. This project will focus on complex, multi‑component membrane assemblies as well as protein‑DNA complexes involved in DNA‑repair, investigated both in‑vitro and live‑cell environments. The research will employ a diverse array of structural biology techniques, including single‑particle cryo‑EM, cross‑linking mass spectrometry, electrophysiology, molecular microbiology, bioinformatics and live‑cell imaging.
About the position: This postdoctoral position is funded by the European Advanced Multiscale Biological imaging with European Research infrastructures (AMBER) program for 3 years and the successful candidate will be based at LISCB/MCB, UK working under the supervision of Dr. Abhinav Koyamangalath Vadakkepat and Dr. Amanda Chaplin. The last date of application is 1st July. Since the application involves the candidate to apply with an extensive proposal, interested candidates are advised to contact Dr Abhinav Koyamangalath Vadakkepat, MCB & LISCB, University of Leicester (akv10@leicester.ac.uk) as early as possible.
Candidate profile:
- PhD in Structural Biology, Biochemistry, Biophysics, Molecular Biology, or a closely related discipline
- Within eight years of PhD submission
- Must not have resided or undertaken their principal activity (work, study, etc.) in the UK for more than 12 months within the three years immediately preceding the call deadline
- Demonstrable experience in designing and executing workflows for protein structure determination, encompassing molecular biology and biochemical techniques such as DNA cloning, mutagenesis, protein purification and structural studies.
- Strong motivation to address fundamental biological questions and contribute to innovative research directions
- Excellent teamworking, communication, and organisational skills, with the ability to work independently within a collaborative research environment
- Expertise in membrane protein expression and purification
- Familiarity with cryo‑EM workflows, including sample preparation, data collection, and processing
- Familiarity with liposome reconstitution and electrophysiology
For informal discussions regarding this position or future opportunities, please contact: Dr Abhinav Koyamangalath Vadakkepat, MCB & LISCB, University of Leicester (akv10@leicester.ac.uk) and Dr Tennie Videler (hv33@le.ac.uk).
Postdoctoral Research Associate in Structural Biology at LISCB, University of Leicester, UK employer: Instruct-ERIC
The University of Leicester offers an exceptional environment for researchers, particularly in the field of Structural Biology, with access to cutting-edge facilities and a supportive, multicultural academic community. As a Postdoctoral Research Associate at the AKV lab, you will have the opportunity to lead innovative research projects while developing your expertise in advanced techniques such as cryo-EM and protein biochemistry, all within a collaborative and dynamic setting that prioritises employee growth and development.
StudySmarter Expert Advice🤫
We think this is how you could land Postdoctoral Research Associate in Structural Biology at LISCB, University of Leicester, UK
✨Tip Number 1
Network like a pro! Reach out to your contacts in the field of structural biology and let them know you're on the lookout for opportunities. A friendly chat can lead to insider info about openings that aren't even advertised yet.
✨Tip Number 2
Don’t just apply, engage! When you find a position that excites you, take the time to contact the hiring manager or relevant faculty member. A quick email expressing your enthusiasm and asking questions can set you apart from the crowd.
✨Tip Number 3
Showcase your skills! Prepare a portfolio or presentation that highlights your previous research and how it relates to the job. This can be a great conversation starter during interviews and shows you’re serious about contributing to their team.
✨Tip Number 4
Apply through our website! We make it easy for you to submit your application directly, ensuring it gets into the right hands. Plus, it shows you’re proactive and keen on joining our vibrant community at the University of Leicester.
We think you need these skills to ace Postdoctoral Research Associate in Structural Biology at LISCB, University of Leicester, UK
Some tips for your application 🫡
Tailor Your Proposal:Make sure your application proposal is specifically tailored to the project at the AKV lab. Highlight your relevant experience in structural biology and how it aligns with the research on host-pathogen interactions and DNA-repair complexes.
Showcase Your Skills:Don’t hold back on showcasing your skills! Emphasise your expertise in membrane protein biochemistry, cryo-EM, and any other techniques mentioned in the job description. We want to see what you can bring to the table!
Reach Out Early:If you have questions or need clarification, don’t hesitate to contact Dr Abhinav Koyamangalath Vadakkepat early on. It shows initiative and helps you understand the expectations better, which can strengthen your application.
Apply Through Our Website:Remember to submit your application through our website! It’s the best way to ensure your application gets the attention it deserves. Plus, it keeps everything organised for us and you.
How to prepare for a job interview at Instruct-ERIC
✨Know Your Research Inside Out
Make sure you’re well-versed in the latest developments in structural biology, especially related to membrane proteins and DNA-repair complexes. Familiarise yourself with the AKV lab's recent publications and projects, as this will show your genuine interest and help you engage in meaningful discussions during the interview.
✨Prepare for Technical Questions
Expect questions about your experience with techniques like cryo-EM, protein purification, and molecular biology workflows. Brush up on your knowledge of these methods and be ready to discuss specific challenges you've faced and how you overcame them. This will demonstrate your hands-on expertise and problem-solving skills.
✨Showcase Your Teamwork Skills
Since the role involves collaboration, be prepared to share examples of how you've successfully worked in teams. Highlight your communication skills and any experiences where you contributed to a project’s success through effective collaboration. This will reassure the interviewers that you can thrive in their vibrant, multicultural academic community.
✨Ask Insightful Questions
Prepare thoughtful questions about the lab's research focus, future projects, or the team dynamics. This not only shows your enthusiasm for the position but also helps you gauge if the lab environment aligns with your career goals. It’s a great way to leave a lasting impression!
