At a Glance
- Tasks: Conduct cutting-edge research in in situ structural biology using advanced microscopy techniques.
- Company: Join the prestigious University of Leeds and be part of a leading research team.
- Benefits: Enjoy a competitive salary, access to state-of-the-art facilities, and opportunities for professional growth.
- Other info: Collaborate with experts and access top-notch resources for innovative research.
- Why this job: Make a real impact in structural biology and advance your career in a dynamic research environment.
- Qualifications: PhD in in situ Structural Biology or related field with experience in cryoEM and cryoET.
The predicted salary is between 34650 - 42350 £ per year.
Are you an ambitious researcher looking for your next challenge? Do you have an established background in in situ structural biology? Do you want to further your career in one of the UK's leading research intensive Universities?
We seek to appoint a Postdoctoral Research Fellow to the research team led by Prof. Elton Zeqiraj in the Faculty of Biological Sciences at the University of Leeds, Leeds, UK. The position is initially available for 3 years. The successful applicant will undertake in situ structural analysis using advanced cryoEM, cryoET and cutting-edge correlative microscopy methods. A major aspect of the post is setting up new pipelines for in situ structural biology and cryoET from cell systems using modern techniques to study ribosome quality control mechanisms. In addition, you will resolve the mode of action and target engagement of signalling proteins using signal particle cryoEM and sub-tomogram averaging. The position will suit someone interested in protein structure, in situ imaging / structural biology and cell signalling.
The project builds on recent work from the laboratory on quality control mechanisms and the mode of action of signalling proteins, which the successful applicant will extend into a native cellular context using in situ cryoET and correlative imaging.
You should have (or be very close to completing) a PhD in in situ Structural Biology, or a related discipline. You should have a strong background in cryoEM, CryoET or related methods, and experience with setting up pipelines for cryoET data processing and/or FIB milling. Experience with in situ structural biology is essential.
The Astbury Centre for Structural & Molecular Biology at the University of Leeds has excellent facilities for in situ structural biology and is fully equipped for cryo-electron microscopy (two Titan Krios 300 kV with Falcon-4 detectors and Selectris energy filters), FIB-milling (Hydra Bio plasma-FIB) high pressure freezing equipment. Computational resources with dedicated workstations are available in the Zeqiraj laboratory and through high performance computer clusters within the University. Additionally, the centre has protein crystallography and protein production facilities with expertise in multi-subunit expression in insect cell, yeast and bacterial expression systems. Other facilities provide capabilities for biophysical interactions, including the latest Biacore, MST, Dianthus (Nanotemper), ITC and Mass Photometry instruments. The University provides state-of-the-art infrastructure for insect cell and mammalian cell culture, high-throughput screening, imaging, mammalian genetics, chemical biology and proteomics.
The deadline for applications is 31 August 2026.
Postdoctoral Research Fellow in In situ Structural Biology in Leeds employer: Instruct-ERIC
The University of Oxford is an exceptional employer, offering a vibrant and collaborative work culture that fosters innovation and academic excellence. As a Postdoctoral Research Assistant in Structural Biology, you will have access to cutting-edge facilities and resources, alongside opportunities for professional development and networking within a world-renowned institution. Located in the historic city of Oxford, you will enjoy a stimulating environment that encourages both personal and professional growth while contributing to groundbreaking research in bacterial membrane biology.
StudySmarter Expert Advice🤫
We think this is how you could land Postdoctoral Research Fellow in In situ Structural Biology in Leeds
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We think you need these skills to ace Postdoctoral Research Fellow in In situ Structural Biology in Leeds
Some tips for your application 🫡
Show Off Your Lab Skills:In the biotechnology field, it's super important to highlight your lab experience in your CV. Be sure to mention specific techniques or instruments you've mastered (think PCR, gel electrophoresis, etc.) and any relevant projects you've worked on. This will show Instruct-ERIC that you have the hands-on skills they need.
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How to prepare for a job interview at Instruct-ERIC
✨Brush Up on Lab Techniques
Since you're eyeing a full-time gig in biotechnology, make sure you're well-versed in the lab techniques relevant to the role. Be ready to talk about PCR, CRISPR, or any specific methods mentioned in the job description at Instruct-ERIC. You might even be asked to demonstrate your understanding of these processes.
✨Know Your Bioinformatics Tools
Get comfortable with bioinformatics tools that are commonly used in the industry, like BLAST or Bioconductor. These are key in biotechnology, and having hands-on experience or at least familiarity can set you apart. Prepare to discuss any relevant projects you've worked on, especially if they involved data analysis or genomic research.
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