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- Tasks: Lead cutting-edge analyses to identify new drug targets for cardiometabolic diseases.
- Company: Major European pharmaceutical client with a focus on R&D AI.
- Benefits: Permanent position in Central London or Oxford with competitive salary and benefits.
- Why this job: Make a real impact on drug discovery using advanced AI and data analysis.
- Qualifications: Master’s or PhD in biology, extensive pharma experience, and strong leadership skills.
- Other info: Collaborative environment with opportunities for scientific innovation and career growth.
The predicted salary is between 72000 - 108000 ÂŁ per year.
Insight Global are seeking a Senior Principal Scientist on behalf of a major European pharmaceutical client of ours, within their R&D AI team. This role is a permanent position, based in either Central London or Oxford.
Overview
As Senior Principal Scientist, you will perform cutting edge analyses of cellular phenotype data derived from ultra-high throughput genetic and compound screens to identify new drug targets for cardiometabolic disease. You will have direct impact on our early pipeline and lead the scientific deliveries from our flagship genome-scale in‑vitro perturbation screens producing high‑content imaging and functional genomics data and help us translate these into compelling drug projects.
Responsibilities Include
- Scientific leadership and execution of high-value AI and data analysis projects for target discovery
- Translation of ultra-high throughput in‑vitro screening analysis results/insights into drug target candidates and pipeline projects
- Systems biology‑guided interrogation of high‑dimensional cell‑painting embeddings & omics (incl. DRUG‑seq/perturb‑seq) data derived from genetic & chemical perturbations
- Keep pace with cutting edge biology‑focused AI methods and contribute to the development of internal evaluations/benchmarks to keep our models focused on value to our discovery pipeline
- Develop collaborative and strategic relationships with key stakeholders in our therapy areas to ensure alignment with the global drug discovery strategy and portfolio
Must-Have Requirements Include
- Master’s degree or a PhD in cellular/molecular/computational biology
- Extensive experience in a pharma/tech bio context
- Scientific leadership experience in cross‑functional teams with a track record of progressing novel biological hypotheses, ideally focused on drug target identification within a pharma industry context
- Experience applying cutting edge AI and systems biology methods to generate, analyse and interpret high‑dimensional datasets, preferably from HCI/omics data on in‑vitro genetic/compound screens
- Independence and motivation to perform in‑depth biology‑focused data analysis and work with project and leadership teams to progress targets
- Experience working in Python/R to curate and analyse data
- Experience in CMD‑relevant cellular/molecular biology is an advantage
Senior Principal Scientist employer: Insight Global
Contact Detail:
Insight Global Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Senior Principal Scientist
✨Tip Number 1
Network like a pro! Reach out to your connections in the pharma and AI sectors. Attend industry events or webinars, and don’t be shy about introducing yourself. You never know who might have the inside scoop on job openings or can put in a good word for you.
✨Tip Number 2
Show off your expertise! Prepare a portfolio or presentation that highlights your previous work in cellular/molecular biology and AI methods. This will not only demonstrate your skills but also give you something tangible to discuss during interviews.
✨Tip Number 3
Practice makes perfect! Conduct mock interviews with friends or mentors in the field. Focus on articulating your experience with high-dimensional datasets and drug target identification. The more comfortable you are discussing your background, the better you'll perform when it counts.
✨Tip Number 4
Apply through our website! We’re always on the lookout for talented individuals like you. Make sure to tailor your application to highlight your scientific leadership and experience with AI in drug discovery. Let’s get you into that Senior Principal Scientist role!
We think you need these skills to ace Senior Principal Scientist
Some tips for your application 🫡
Tailor Your CV: Make sure your CV is tailored to the Senior Principal Scientist role. Highlight your experience in cellular/molecular biology and any relevant AI projects you've worked on. We want to see how your background aligns with our needs!
Craft a Compelling Cover Letter: Your cover letter is your chance to shine! Use it to explain why you're passionate about drug discovery and how your skills can contribute to our R&D AI team. Let us know what excites you about this opportunity!
Showcase Your Leadership Skills: Since this role involves scientific leadership, be sure to highlight your experience leading cross-functional teams. Share specific examples of how you've progressed novel biological hypotheses in your previous roles.
Apply Through Our Website: We encourage you to apply directly through our website. It’s the best way for us to receive your application and ensures you’re considered for the role. Plus, it shows us you’re keen to join our team!
How to prepare for a job interview at Insight Global
✨Know Your Science
Make sure you brush up on the latest trends in cellular and molecular biology, especially those related to drug target identification. Be ready to discuss your previous projects and how they relate to the role, showcasing your scientific leadership and experience in cross-functional teams.
✨Showcase Your AI Skills
Since this role involves cutting-edge AI methods, be prepared to talk about your experience with Python or R. Bring examples of how you've applied these tools to analyse high-dimensional datasets, particularly in a pharma context, and how that can translate into value for their discovery pipeline.
✨Demonstrate Collaboration
Highlight your ability to develop strategic relationships with stakeholders. Prepare examples of how you've worked with different teams to align on drug discovery strategies, as collaboration is key in this role. Show them you can lead and inspire others in a scientific setting.
✨Ask Insightful Questions
Prepare thoughtful questions about their R&D AI team and the specific challenges they face in drug target discovery. This shows your genuine interest in the role and helps you understand how you can contribute to their goals, making you a more compelling candidate.
