At a Glance
- Tasks: Lead innovative projects in epigenomics to tackle Alzheimer's and dementia research.
- Company: Join the UK Dementia Research Institute at Imperial College London, a leader in scientific innovation.
- Benefits: Competitive salary, 41 days off, generous pension, and career development opportunities.
- Other info: Collaborative environment with mentoring opportunities and strong national research links.
- Why this job: Make a real impact in dementia research while working with cutting-edge technologies.
- Qualifications: Experience in (epi)genomics, nuclei isolation, and single-cell genomic technologies.
The predicted salary is between 49017 - 57472 € per year.
Launched in 2017, the UK DRI stands as a beacon of scientific innovation, representing an unprecedented £300 million investment in dementia research - the largest of its kind in UK history. The purpose of the UK DRI is to transform the outlook for people living with or at risk of neurodegenerative conditions through research.
Applications are invited for a Research Associate in oligodendrocyte and neuroimmune epigenomics to join the lab of Dr Alexi Nott in the UK DRI at Imperial. Following a new collaborative UK DRI Key Questions Award with Dr Sarah Marzi, Dr Rikesh Rajani, and Dr Dervis Salih, we are seeking to appoint a dynamic postdoctoral researcher to lead one or more projects to characterise the epigenome of oligodendrocytes and neuroimmune cell types in early Alzheimer's and resilience to dementia using patient-derived samples. This post is funded for three years: the first 1.5 years based at Imperial on the White City Campus under the guidance of Dr Alexi Nott, where you will profile the epigenome of brain-derived oligodendrocytes and neuroimmune cell types. The second phase of the project will be in the lab of Dr Sarah Marzi, at the Denmark Hill Campus of King's College London, to examine the epigenome of macroglia at single-cell resolution.
You will contribute to the design and generation of large-scale 'omics datasets with a primary focus on epigenomic analysis at cell-type-enriched and single-nuclei resolution to address major research questions relevant to Alzheimer's and resilience to dementia.
What you would be doing
- Using your experience in (epi)genomics of the brain, you will generate cell-type-enriched and single-nuclei CUT&Tag data from patient-derived brain tissue and stem cell model systems.
- Work collaboratively as part of a multi-site, multidisciplinary research team.
What we are looking for
- A motivated and organised researcher who is excited by the science we do!
- Experience in nuclei isolation, preferably from brain and/or human tissue.
- Experience of fluorescence-activated nuclei sorting (FANS), and/or FACS.
- Experience in epigenomics and/or single-cell genomic technologies.
What we can offer you
- This role is part of the UK Dementia Research Institute (UK DRI) at Imperial College London, located in the Department of Brain Sciences. Postdocs in the UK DRI at Imperial enjoy excellent career development opportunities with access to a range of cutting-edge technologies.
- An inclusive and collegial working environment with the opportunity to mentor, supervise and teach students.
- Strong national links through the UK DRI with attendance at its annual scientific meeting 'Connectome'.
- The opportunity to continue your career at a world-leading institution and be part of our mission to continue science for humanity.
- Grow your career: gain access to Imperial's sector-leading dedicated career support for researchers as well as opportunities for promotion and progression.
- Sector-leading salary and remuneration package (including 41 days off a year and generous pension schemes).
- Be part of a diverse, inclusive and collaborative work culture with various staff networks and resources to support your personal and professional wellbeing.
This is a Full time fixed term role based at our White City Campus. If you require any further details about the role, please contact: Dr Alexi Nott at a.nott@imperial.ac.uk and Dr Sarah Marzi at sarah.marzi@kcl.ac.uk.
Research Associate in Epigenomics - UK Dementia Research Institute - London employer: Imperial College London
The UK Dementia Research Institute at Imperial College London is an exceptional employer, offering a dynamic and inclusive work environment that fosters collaboration and innovation in the field of dementia research. With access to cutting-edge technologies and strong career development opportunities, employees can thrive while contributing to meaningful scientific advancements. Located in the vibrant White City Campus, the institute provides a supportive culture with generous benefits, including 41 days of annual leave and a robust pension scheme, making it an attractive place for researchers passionate about making a difference.
StudySmarter Expert Advice🤫
We think this is how you could land Research Associate in Epigenomics - UK Dementia Research Institute - London
✨Tip Number 1
Network like a pro! Reach out to current or former employees at the UK Dementia Research Institute on LinkedIn. A friendly chat can give us insights into the team culture and maybe even a referral!
✨Tip Number 2
Prepare for the interview by diving deep into the latest research in epigenomics and dementia. We want to show that we’re not just passionate but also knowledgeable about the field!
✨Tip Number 3
Practice our pitch! We should be ready to explain how our experience aligns with the role. Highlight specific projects or skills that relate directly to the job description.
✨Tip Number 4
Don’t forget to apply through our website! It’s the best way to ensure our application gets seen by the right people. Plus, it shows we’re serious about joining the team!
We think you need these skills to ace Research Associate in Epigenomics - UK Dementia Research Institute - London
Some tips for your application 🫡
Tailor Your CV:Make sure your CV is tailored to the role of Research Associate in Epigenomics. Highlight your experience in (epi)genomics, nuclei isolation, and any relevant technologies like FACS or FANS. We want to see how your skills align with what we're looking for!
Craft a Compelling Cover Letter:Your cover letter is your chance to shine! Use it to express your passion for dementia research and how you can contribute to our mission at the UK DRI. Be genuine and let us know why you're excited about this opportunity.
Showcase Your Collaborative Spirit:Since this role involves working in a multidisciplinary team, make sure to highlight any previous collaborative projects you've been part of. We love seeing how you work with others to achieve common goals!
Apply Through Our Website:Don't forget to apply through our website! It’s the best way to ensure your application gets to us directly. Plus, you’ll find all the details you need about the role and our team there.
How to prepare for a job interview at Imperial College London
✨Know Your Epigenomics Inside Out
Make sure you brush up on your knowledge of epigenomics, especially in relation to neurodegenerative conditions like Alzheimer's. Be prepared to discuss your previous research experiences and how they relate to the role, particularly any work with nuclei isolation or single-cell genomic technologies.
✨Show Your Collaborative Spirit
This position involves working within a multidisciplinary team across multiple sites. Highlight your teamwork skills and any past experiences where you've successfully collaborated with others. Be ready to share examples of how you’ve contributed to group projects and what you learned from those experiences.
✨Prepare Questions for Your Interviewers
Demonstrate your genuine interest in the role by preparing thoughtful questions for Dr Alexi Nott and the team. Ask about the specific projects you'll be involved in, the lab culture, or how success is measured in this role. This shows that you're not just interested in the job, but also in the impact of your work.
✨Practice Your Presentation Skills
You might be asked to present your previous research during the interview. Make sure you can clearly explain your methodologies and findings, and how they relate to the work at the UK DRI. Practising your presentation will help you communicate your ideas effectively and confidently.
