Purpose of the role
We are looking for a postdoctoral scientist to join Prof Christina
Zielinski’s group to work in the field of human T-cell regulation.
This role offers the opportunity to work at the forefront of human T
cell immunology using cutting edge cellular, molecular approaches,
protein biochemistry and imaging.
About the Zielinski Lab:
Our lab investigates novel functions, molecular pathways and the
translational relevance of human T cells in clinical situations such
as infections, autoimmunity and cancer. We are interested in the
identification and characterization of novel T cell functions in the
human tissue microenvironment and in their dissection at the
molecular level. We have recently shown that innate signalling
platforms are operative in human T cells and are interested in
further exploring their role for adaptive immunity and their
regulation.
About the role:
Your project will focus on the molecular regulation of new T cell
functions and signalling platforms using state-of-the-art and cutting
edge technologies in protein biochemistry, imaging, gene editing
etc. The project will involve studying the role and regulation of T cell
derived extracellular vesicles. As a postdoc, you will have the
opportunity to engage in multiple projects and to collaborate with
junior scientists of the team and to supervise junior team members.
You will also collaborate with clinicians to obtain human tissue
samples. Expertise in T cell biology and the regulation of
cytotoxicity and cell death is strongly encouraged as a prerequisite
for application. Computational (scRNAseq) and modelling expertise
is a plus.
You may also pursue a research agenda of your interest and
contribute with new technologies and T cell-related questions that
fit into the overall vision of our team.
Key responsibilities
Research and Scholarship:
- Develop research objectives and proposals for own or joint research.
- Conduct individual and collaborative research projects.
- Write up research work for presentation and publication.
- Continually update knowledge and understanding in field or specialism.
- Translate knowledge of advances in the subject areas into research activity.
- Manage own research and administrative activities, with guidance if required.
- Assist in the preparation of proposals and applications to external bodies, e.g. for
funding and contractual purposes. - Communicate material of a specialist or highly technical nature.
- Contribute to the general lab management.
Teaching and Learning Support: - May assist in the supervision of student projects.
- Provide limited supervision/instruction to classes.
- May assist in the development of student research skills.
- May plan and deliver seminars relating to research area.
Liaison and Networking: - Liaise with colleagues and students; build internal and external contacts and
participate in networks for the exchange of information and to form relationships for
future collaboration. - Planning and Organising:
- Contribute significantly to shaping the scientific direction of the project
- Identify, develop, and optimise techniques needed to achieve project aims
- Introduce innovative approaches where required.
- Write manuscripts for publication in peer-reviewed journals, contribute to reporting of
research results. - Plan the use of research resources, laboratories and workshops as appropriate.
- Plan and manage own research activity in collaboration with others.
- Contribute to planning of joint research projects led by principal investigator.
- Contribute to establishing biobanks (human tissue samples, PBMC) for project
associated investigations.
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