Senior Scientist II, Antibody Platform

Vacancy Name: Senior Scientist II, Antibody Platform

Vacancy No: VN515

Employment Type: Full Time

Location of role: Oxford, UK

Key Responsibilities

It’s the perfect time to join Immunocore, a pioneering biotech with a collegial atmosphere and a passion for harnessing every individual’s unique set of skills in our fight against disease.

As a Senior Scientist working in the Antibody Platform team, you will provide expertise in multi-specific antibodies and antibody-related technologies to drive in-house innovation and further advance Immunocore’s technologies and multi-specific platforms. This is an exciting technology-focused role, so innovation and execution are key factors for success. Working within the Antibody Platform team, you will provide scientific and technical laboratory expertise relating to antibody discovery, isolation, production, engineering, and optimisation.

With our successful launch in 2022 of the world’s first TCR-based medicine, KIMMTRAK, which is also the first launched treatment for any solid tumour, you will be joining us at the most exciting time in our history, and be part of a team that values innovation, trust, and collaboration.

1. Provide deep scientific and technical expertise in antibody research, including antibody fragments such as scFv and VHH, bispecifics, and multi-specifics.
2. Design and production of multi-specific antibody-based molecules, establishing robust expression, purification, and characterisation strategies.
3. Antibody fragment discovery via in vitro platforms such as phage display, library construction, selection, and screening.
4. Engineering of antibody fragments, including affinity maturation, format optimisation, and developability approaches.
5. Identify and work up innovative antibody technologies that will benefit our multi-specific discovery pipeline.
6. Analyse, interpret and effectively communicate plans and findings at departmental, project, and leadership team meetings, providing go/no-go recommendations.
7. Independently plan, design, and execute experimental projects of diverse scope, troubleshooting problems and providing recommendations on next steps.
8. Contribute to peer-reviewed publications, patents, and international conferences.
9. Contribute to internal and external collaborations.
10. Provide technical training to team members where required.
11. Ensure own work, and work of peers, follows Good Laboratory Practice, and adheres to Immunocore health and safety policies.

Person Specification

Experience and Knowledge

Essential

• Strong experience in molecular biology and advanced protein expression and purification techniques e.g. PCR, antibody V-gene cloning, antibody expression & purification in bacterial and/or mammalian systems.
• Experience in protein biophysical characterisation methods such as SPR or BLI.
• Experience in acting as technical lead on project teams, explaining complex concepts to key stakeholders.
• Track record of identifying, evaluating, and making recommendations on new technologies to pursue.
• Track record of solving scientific problems creatively.
• Track record of collaborating and contributing as a project team member.
• Effective communication of scientific concepts and findings.

Desirable

• Experience in engineering and evaluation of multi-specific antibody formats.
• Experience in troubleshooting and optimising expression and purification of complex antibody-based molecules.
• Knowledge of biologics drug discovery.
• Experienced in the use of automation e.g., colony picking, liquid handlers.

About the Company

Immunocore (NASDAQ: IMCR) is a pioneering, commercial-stage T cell receptor biotechnology company whose purpose is to develop and commercialize a new generation of transformative medicines which address unmet patient needs in oncology, infectious diseases, and autoimmune disease. Our leaders in R&D are internationally recognised as some of the biotech industry’s most successful drug developers. We are creating not just an environment where great minds can interact but an innovation powerhouse answering the big questions.

Focused on delivering first-in-class biological therapies to patients, we have developed a highly innovative soluble TCR platform. Our ImmTAX molecules underpin a new generation of precision-engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical need, including oncology, infectious diseases, and autoimmune diseases.

At Immunocore, we recognize that our employees are our greatest asset. We value the unique contributions each person brings to our team. By embracing Science, Trust, Respect, Integrity, Diversity, and Entrepreneurship (STRIDE), we create an environment where collaboration thrives, ideas flourish, and transformative changes happen. STRIDE represents more than just letters; it embodies our shared identity and drives our mission. We are dedicated to developing breakthrough therapies that transform patients’ lives, advancing medicine, and supporting one another in these pursuits.

Immunocore is proud to be an equal opportunity employer. As such, we are committed to fostering an inclusive workplace where everyone feels valued, respected, and empowered. We encourage applications from individuals of all backgrounds, regardless of race, color, religion, sex, sexual orientation, gender identity or expression, pregnancy, age, national origin, disability status, or any other characteristic protected by law.

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