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- Tasks: Lead innovative analytical methods for biopharmaceutical development and mentor junior scientists.
- Company: Join Immunocore, a pioneering biotech company transforming medicine with cutting-edge therapies.
- Benefits: Competitive salary, inclusive culture, and opportunities for professional growth.
- Why this job: Make a real impact in healthcare by developing breakthrough therapies for patients in need.
- Qualifications: Strong background in large molecule analytical science and method development.
- Other info: Collaborative environment focused on innovation and diversity.
The predicted salary is between 43200 - 72000 £ per year.
Overview
Job Details: Senior Scientist II Analytical Development – Bioprocess Analytics. Full details of the job.
Vacancy Name Senior Scientist II Analytical Development – Bioprocess Analytics
Vacancy No VN690
Employment Type Full Time
Location Oxford, UK
Department CMC
Responsibilities
- Contribute to analytical program strategies across the therapeutic project portfolio.
- Represent analytical development within cross-functional project teams, providing strategic support and technical consultancy.
- Lead development of robust impurity analytical methods to support effective development of the Immunocore therapeutic drug portfolio, including methods such as host cell protein ELISA, 2D Western blotting, host cell DNA and/or endotoxin assays as well as HPLC of residual impurities.
- Lead development and oversight of product and process impurity control strategy and characterisation in aid of product development.
- Oversee technical transfer and validation of assays at contract manufacturers in line with ICH regulatory guidelines, and develop phase appropriate specifications.
- Support digital transformation project in defining key analytical outputs and identify methods to streamline data handling.
- Develop scientists of lower grades within the analytical development team.
- Prepare reports and presentations of high quality suitable for internal and external audiences.
- Be a lead author of relevant sections of CMC regulatory documentation, e.g., IND, IMPD, BLA, MAA and responses to any agency questions.
- Keep abreast of developments in area of expertise to advance company activities where deemed appropriate; providing in-depth analysis of new techniques and theories to advance the way the company works, raising and championing these with leaders and colleagues across the company.
- Review competing priorities for projects and provide clear and thorough recommendations, considering the overall goals of the project, department and company.
- Implement safe working practices in laboratories for the team according to Immunocore EHS policies.
Qualifications
Experience & knowledge
Essential
- Strong knowledge of large molecule analytical science.
- Expert in analytical method development in support of impurity assessment of biopharmaceutical drug candidate development. Expertise in at least two of the following: host cell protein ELISA, 2D Western blotting, HPLC of residual impurities or endotoxin assays.
- Experienced in process-related impurity characterisation and control for biologic drug molecules.
- Experienced in phase-appropriate assay validation.
- Strong track record of collaborating on projects with a team.
- Excellent communicator that proactively interacts with cross-functional stakeholders.
- Presented detailed scientific findings to internal and external audiences.
- Mentored and coached less experienced colleagues in scientific practices and theory.
- Owned, participated and provided input to regulatory submission documentation and discussions.
Desirable
- Experience with Charge Aerosol Detector HPLC methods.
- Experience with low endotoxin recovery.
- Experience with extractable & leachable assessments.
- Bioinformatics and data management experience in a CMC setting.
- Built a network of external scientific contacts as both a contributor and recipient.
- Contributed to and influenced the strategic scientific direction within the CMC department and company on the whole.
- Relevant experience with people line-management in biopharmaceutical industry.
Education & qualifications
- Essential: BSc. Or MSc. in biochemistry, molecular biology or related discipline.
- Desirable: PhD in related discipline.
About the Company
Immunocore (NASDAQ: IMCR) is a pioneering, commercial-stage T cell receptor biotechnology company whose purpose is to develop and commercialize a new generation of transformative medicines which address unmet patient needs in oncology, infectious diseases and autoimmune disease. Our leaders in R&D are internationally recognised as some of the biotech industry’s most successful drug developers. We are creating not just an environment where great minds can interact but an innovation powerhouse answering the big questions.
Focused on delivering first-in-class biological therapies to patients, we have developed a highly innovative soluble TCR platform. Our ImmTAX molecules underpin a new generation of precision engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical need, including oncology, infectious diseases and autoimmune diseases.
At Immunocore, we recognize that our employees are our greatest asset. We value the unique contributions each person brings to our team. By embracing Science, Trust, Respect, Integrity, Diversity, and Entrepreneurship (STRIDE), we create an environment where collaboration thrives, ideas flourish, and transformative changes happen. STRIDE represents more than just letters; it embodies our shared identity and drives our mission. We are dedicated to developing breakthrough therapies that transform patients’ lives, advancing medicine, and supporting one another in these pursuits.
Immunocore is proud to be an equal opportunity employer. As such, we are committed to fostering an inclusive workplace where everyone feels valued, respected, and empowered. We encourage applications from individuals of all backgrounds, regardless of race, color, religion, sex, sexual orientation, gender identity or expression, pregnancy, age, national origin, disability status, or any other characteristic protected by law.
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Senior Scientist II Analytical Development - Bioprocess Analytics employer: Immunocore
Contact Detail:
Immunocore Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Senior Scientist II Analytical Development - Bioprocess Analytics
✨Tip Number 1
Network like a pro! Reach out to your connections in the biopharmaceutical industry, especially those who work at Immunocore or similar companies. A friendly chat can lead to insider info about job openings and even referrals.
✨Tip Number 2
Prepare for interviews by brushing up on your technical knowledge. Make sure you can confidently discuss methods like ELISA and HPLC, as well as your experience with impurity assessment. We want to see your expertise shine!
✨Tip Number 3
Showcase your leadership skills! If you've mentored others or led projects, be ready to share those experiences. We love candidates who can inspire and develop their teams, so let us know how you've made an impact.
✨Tip Number 4
Don’t forget to apply through our website! It’s the best way to ensure your application gets seen. Plus, it shows you're genuinely interested in joining our innovative team at Immunocore.
We think you need these skills to ace Senior Scientist II Analytical Development - Bioprocess Analytics
Some tips for your application 🫡
Tailor Your Application: Make sure to customise your CV and cover letter to highlight your experience in large molecule analytical science and method development. We want to see how your skills align with the specific requirements of the Senior Scientist II role.
Showcase Your Achievements: Don’t just list your responsibilities; share your accomplishments! Use quantifiable results where possible, like successful projects or improvements you’ve made in previous roles. This helps us see the impact you've had in your past positions.
Be Clear and Concise: When writing your application, clarity is key. Use straightforward language and avoid jargon unless it’s relevant to the role. We appreciate a well-structured application that’s easy to read and gets straight to the point.
Apply Through Our Website: We encourage you to submit your application through our website for the best chance of being noticed. It’s the easiest way for us to keep track of your application and ensure it reaches the right people!
How to prepare for a job interview at Immunocore
✨Know Your Analytical Methods
Make sure you brush up on your knowledge of large molecule analytical science, especially methods like host cell protein ELISA and HPLC. Be ready to discuss your experience with these techniques and how they relate to impurity assessment in biopharmaceuticals.
✨Showcase Your Team Collaboration Skills
Since this role involves working within cross-functional project teams, prepare examples of past collaborations. Highlight how you’ve contributed to team success and how you’ve communicated effectively with stakeholders.
✨Prepare for Regulatory Discussions
Familiarise yourself with CMC regulatory documentation processes. Be prepared to discuss your experience with IND, IMPD, BLA, and MAA submissions, as well as any challenges you've faced and how you overcame them.
✨Demonstrate Your Mentoring Experience
As a Senior Scientist, you'll likely be mentoring less experienced colleagues. Think of specific instances where you've coached others in scientific practices and how that has impacted their development and the team's performance.
