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- Tasks: Lead analytical strategies and develop methods for biopharmaceutical drug candidates.
- Company: Immunocore is a pioneering biotech firm focused on transformative medicines for serious diseases.
- Benefits: Enjoy a collaborative environment, career development opportunities, and a commitment to diversity and inclusion.
- Why this job: Join a team that values innovation and makes a real impact on patient lives.
- Qualifications: BSc or MSc in biochemistry or related field; PhD preferred. Strong analytical science knowledge required.
- Other info: Equal opportunity employer committed to fostering an inclusive workplace.
The predicted salary is between 48000 - 72000 £ per year.
Immunocore (NASDAQ: IMCR) is a pioneering, commercial-stage T cell receptor biotechnology company whose purpose is to develop and commercialize a new generation of transformative medicines which address unmet patient needs in oncology, infectious diseases and autoimmune disease. Our leaders in R&D are internationally recognised as some of the biotech industry's most successful drug developers. We are creating not just an environment where great minds can interact but an innovation powerhouse answering the big questions. Focused on delivering first-in-class biological therapies to patients, we have developed a highly innovative soluble TCR platform. Our ImmTAX molecules underpin a new generation of precision engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical need, including oncology, infectious diseases and autoimmune diseases.
At Immunocore, we recognize that our employees are our greatest asset. We value the unique contributions each person brings to our team. By embracing Science, Trust, Respect, Integrity, Diversity, and Entrepreneurship (STRIDE), we create an environment where collaboration thrives, ideas flourish, and transformative changes happen. STRIDE represents more than just letters; it embodies our shared identity and drives our mission. We are dedicated to developing breakthrough therapies that transform patients' lives, advancing medicine, and supporting one another in these pursuits. Immunocore is proud to be an equal opportunity employer. As such, we are committed to fostering an inclusive workplace where everyone feels valued, respected, and empowered. We encourage applications from individuals of all backgrounds, regardless of race, color, religion, sex, sexual orientation, gender identity or expression, pregnancy, age, national origin, disability status, or any other characteristic protected by law.
As Principal Scientist, Analytical Development, you will shape and execute analytical strategies across Immunocore's therapeutic project portfolio, driving the development and oversight of robust impurity analytical methods and control strategies. Acting as a strategic partner within cross-functional teams, you'll provide expert technical consultancy and guide the technical transfer and validation of assays at contract manufacturers. Your leadership will be instrumental in delivering high-quality data and impactful contributions to the advancement of Immunocore's therapeutic pipeline.
KEY RESPONSIBILITIES- Set and influence analytical program strategies across our therapeutic project portfolio.
- Represent analytical development within cross-functional project teams, providing strategic support and technical consultancy.
- Lead development of robust impurity analytical methods to support effective development of the Immunocore therapeutic drug portfolio, including host cell protein ELISA, 2D Western blotting, DNA and endotoxin assays as well as HPLC of residual impurities.
- Lead development and oversight of product and process impurity control strategy and characterisation in aid of product development.
- Oversee technical transfer and validation of assays at contract manufacturers in line with ICH regulatory guidelines, and develop phase appropriate specifications.
- Support digital transformation program in defining key analytical outputs and identify methods to streamline data handling.
- Develop scientists of lower grades within the analytical development team.
- Prepare reports and presentations of high quality suitable for internal and external audiences.
- Be a lead author of relevant sections of CMC regulatory documentation, e.g., IND, IMPD, BLA, MAA and responses to any agency questions.
- Keep abreast of developments in area of expertise to advance company activities where deemed appropriate; providing in-depth analysis of new techniques and theories to advance the way the company works, raising and championing these with leaders and colleagues across the company.
- Review competing priorities for projects and provide clear and thorough recommendations, considering the overall goals of the project, department and company.
- Implement safe working practices in laboratories for the team according to Immunocore EHS policies.
- Strong knowledge of large molecule analytical science.
- Expert in analytical method development in support of biopharmaceutical drug candidate development, including host cell protein ELISA, 2D Western blotting as well as HPLC of residual impurities and endotoxin assays.
- Experienced in process-related impurity characterisation and control for biologic drug molecules.
- Experienced in phase-appropriate assay validation.
- Strong track record of collaborating on projects with a team.
- Excellent communicator that proactively interacts with cross-functional stakeholders.
- Presented detailed scientific findings to internal and external audiences.
- Mentored and coached less experienced colleagues in scientific practices and theory.
- Owned, participated and provided input to regulatory submission documentation and discussions.
- Experience with Charge Aerosol Detector HPLC methods.
- Experience with extractable & leachable assessments.
- Bioinformatics and data management experience in a CMC setting.
- Built a network of external scientific contacts as both a contributor and recipient.
- Contributed to and influenced the strategic scientific direction within the CMC department and company on the whole.
- Relevant experience with people line-management in biopharmaceutical industry.
Desirable: PhD in related discipline.
Principal Scientist I Analytical Development employer: Immunocore
Contact Detail:
Immunocore Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Principal Scientist I Analytical Development
✨Tip Number 1
Network with professionals in the biopharmaceutical industry, especially those who have experience in analytical development. Attend relevant conferences or webinars to connect with potential colleagues and learn about the latest trends in large molecule analytical science.
✨Tip Number 2
Familiarise yourself with Immunocore's specific therapeutic projects and their innovative soluble TCR platform. Understanding their pipeline will allow you to tailor your discussions and demonstrate how your expertise aligns with their goals during interviews.
✨Tip Number 3
Prepare to discuss your experience with impurity analytical methods and regulatory guidelines. Be ready to provide examples of how you've successfully led projects or contributed to the development of robust analytical strategies in previous roles.
✨Tip Number 4
Showcase your leadership skills by highlighting any mentoring or coaching experiences you've had. Immunocore values collaboration and development, so demonstrating your ability to guide less experienced colleagues will resonate well with their team culture.
We think you need these skills to ace Principal Scientist I Analytical Development
Some tips for your application 🫡
Tailor Your CV: Make sure your CV highlights relevant experience in large molecule analytical science and method development. Use specific examples that demonstrate your expertise in techniques like ELISA, Western blotting, and HPLC.
Craft a Compelling Cover Letter: In your cover letter, express your passion for biopharmaceuticals and how your background aligns with Immunocore's mission. Mention your experience in cross-functional teams and your ability to mentor others, as these are key aspects of the role.
Showcase Your Communication Skills: Since excellent communication is essential for this position, include examples of how you've effectively presented scientific findings to diverse audiences. Highlight any experience you have in preparing regulatory documentation.
Demonstrate Leadership Experience: If you have experience mentoring or leading teams, be sure to include this in your application. Discuss how you've contributed to the strategic direction of projects and supported less experienced colleagues in their development.
How to prepare for a job interview at Immunocore
✨Showcase Your Analytical Expertise
Be prepared to discuss your experience with large molecule analytical science in detail. Highlight specific methods you've developed, such as host cell protein ELISA or HPLC techniques, and be ready to explain how these have contributed to successful drug development.
✨Demonstrate Cross-Functional Collaboration
Immunocore values teamwork, so share examples of how you've worked effectively within cross-functional teams. Discuss any challenges you faced and how you overcame them, showcasing your ability to communicate and collaborate with diverse stakeholders.
✨Prepare for Regulatory Discussions
Since the role involves contributing to regulatory documentation, brush up on your knowledge of IND, IMPD, BLA, and MAA submissions. Be ready to discuss your previous experiences with regulatory bodies and how you navigated those processes.
✨Emphasise Mentorship and Leadership Skills
As a Principal Scientist, you'll be expected to mentor junior scientists. Share your experiences in coaching and developing others, and provide examples of how you've fostered a collaborative and supportive environment in your previous roles.
