Formulation Development Scientist in Oxford

Location of role: Oxford, UK

Department: CMC

Key Responsibilities

• The role will cover developing and performing In Use Stability studies to assess device compatibility for clinical use.
• Supporting assays to assess characteristics, quantity, identity, activity and purity of administered drug product to make recommendations on the suitability of different patient delivery systems for Immunocore’s bio-pharmaceuticals.
• The role will require precision, meticulous data recording and an ability to critically analyse data for regulatory submissions and to advise clinical sites on potential patient safety issues.
• To work in close collaboration with other formulation team members, CMC teams and related functions to input into the formulation related sections for regulatory filings, development reports and other development related documents.

Key Responsibilities – All Scientists

• Conducting experiments, observing, interpreting and responding to results.
• Maintaining and increasing technical knowledge in relevant fields through self-study, observation, attending relevant conferences and training courses.
• Maintaining accurate records of all work by completing laboratory notebooks on time, following Company procedures.
• Ensuring that laboratory equipment is operated in accordance with safety and risk guidelines; acting promptly to report any faults or problems to the relevant member of staff.
• Operating in accordance with the Company’s Health and Safety policies, especially within a laboratory environment.

Specific Responsibilities

• Experiments: independently testing and, increasingly, leading lines of investigation. Proposing new experiments based on emerging data and other related information. Providing support on technical aspects to others.
• To conduct In Use Stability studies to assess impact of closed system transfer devices.
• To conduct studies to determine compatibility of plastics, stress factors on drug administration product and other deviations from pharmacy preparation procedure that may occur to determine impact.
• Represent IUS team in formulation team meetings.
• Communicate key findings to managers and scientists in other groups.
• Review/sign-off of routine assays.
• Writing of SOPs.
• Contributing to regulatory documentation.
• Participation in laboratory maintenance.
• Introduce new science into the formulation group.

Priorities

• Establishing priorities for own work and team-based projects; making decisions on prioritisation based on the overall goals of the team, department and project, using direct evidence and personal experience as guidance.

Technical Knowledge

• Sharing knowledge with the wider team and, across departments representing the department both internally and externally. May also act as a mentor or manager to other colleagues, especially new hires, sharing scientific and company knowledge.
• Increasingly providing analysis of new techniques and theories from outside the Company to advance the way the company works; sharing these with leaders across the Company.

Laboratory records

• Ensuring that all records and information are up to date, on time and recorded to the correct standard. Supporting and encouraging others to achieve this.

Laboratory equipment

• Providing technical guidance to others within the team on how to use equipment most effectively; making recommendations regarding acquisition of new pieces of equipment.

Health & Safety

• Championing and helping others to understand H&S within the company, providing ad-hoc training as required.

Reporting

• Communicating and presenting research findings at meetings with colleagues, senior management and partners.

Essential - Experience and Knowledge

• Background in plate based assays eg ELISAs and MSD assays.
• Experience in working independently with accuracy and precision.
• Strong expertise in sub-visible particle analysis, and other compendial techniques such as pH, Western Blotting, SDS PAGE and core lab techniques.

Desirable

• Experience of In Use Stability studies and an understanding of clinical devices in the IV infusion process.
• Familiar with biopharmaceutical stability study principles.
• Familiarity with drug delivery formats.
• Proactive in ensuring high quality of their own work and seeking additional responsibilities to help meet team goals.
• Presented detailed scientific findings and papers to internal and external audiences.

Education & Qualifications

• Essential: BSc.Hons., or MSc. In Biochemistry, Biophysical Chemistry, Physical Chemistry, Molecular Biology, Bio-Manufacturing or related discipline.
• Desirable: PhD in related discipline.

About the Company

Immunocore (NASDAQ: IMCR) is a pioneering, commercial-stage T cell receptor biotechnology company whose purpose is to develop and commercialize a new generation of transformative medicines which address unmet patient needs in oncology, infectious diseases and autoimmune disease. Our leaders in R&D are internationally recognised as some of the biotech industry’s most successful drug developers. We are creating not just an environment where great minds can interact but an innovation powerhouse answering the big questions.

Focused on delivering first-in-class biological therapies to patients, we have developed a highly innovative soluble TCR platform. Our ImmTAX molecules underpin a new generation of precision engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical need, including oncology, infectious diseases and autoimmune diseases.

At Immunocore, we recognize that our employees are our greatest asset. We value the unique contributions each person brings to our team. By embracing Science, Trust, Respect, Integrity, Diversity, and Entrepreneurship (STRIDE), we create an environment where collaboration thrives, ideas flourish, and transformative changes happen. STRIDE represents more than just letters; it embodies our shared identity and drives our mission. We are dedicated to developing breakthrough therapies that transform patients’ lives, advancing medicine, and supporting one another in these pursuits.

Immunocore is proud to be an equal opportunity employer. As such, we are committed to fostering an inclusive workplace where everyone feels valued, respected, and empowered. We encourage applications from individuals of all backgrounds, regardless of race, color, religion, sex, sexual orientation, gender identity or expression, pregnancy, age, national origin, disability status, or any other characteristic protected by law.