Machine Learning Scientist — Large Multimodal Models (Post-Training)

We are seeking a Machine Learning Scientist to join the Enchant team at Iambic Therapeutics. Our mission is to deliver better medicines through innovation in AI-based discovery technologies. In this role, you will research and develop post-training methods for Enchant - our multimodal transformer model trained on a wide variety of biomedical data - pushing the boundaries of what large-scale foundation models can achieve in drug discovery.

The role centers on designing and evaluating post-training approaches for large multimodal language models including supervised fine-tuning, parameter-efficient fine-tuning, reinforcement learning, preference or reward-based optimization, and other emerging post-training methods. You will develop rigorous evaluations and training infrastructure that make it possible to rapidly iterate on these approaches at scale and work closely with colleagues across machine learning, software engineering, and drug discovery to put powerful foundation models into the hands of scientists making real therapeutic decisions. We are hiring across multiple levels and welcome candidates ranging from recent PhD graduates to experienced researchers with a strong publication or deployment record. This is a remote position, with the option to be on-site in our Bristol office.

Key Responsibilities

• Research and develop post-training strategies for large-scale multimodal foundation models
• Design reward functions, training objectives, data-generation strategies, and evaluation protocols for reinforcement learning and other post-training approaches applied to multimodal LLMs
• Build systematic experimentation and hyperparameter optimization workflows to efficiently explore post-training recipes, model configurations, and training strategies
• Develop and apply inference optimization techniques to support deployment in both high-throughput model evaluation and interactive discovery workflows
• Design and maintain rigorous benchmarking and evaluation frameworks that measure model quality across modalities, downstream tasks, and scientific use cases
• Collaborate with ML and software engineering colleagues to productionize models, evaluation systems, and inference services
• Partner with computational chemists, medicinal chemists, and biologists to ensure model development and post-training objectives are grounded in drug discovery needs
• Communicate results to internal teams, external partners, and at conferences
• Write high-quality research and engineering code: refactor, test, document, and package ML components to support team velocity

Qualifications

• PhD in machine learning, computer science, computational chemistry, physics, or a related computational STEM field, or equivalent industry experience demonstrating comparable depth
• Strong Python and PyTorch skills, including implementing, training, debugging and evaluating deep learning models end-to-end
• Demonstrated experience training large-scale transformer models
• Demonstrated experience in one or more of the following:
• Reinforcement learning approaches such as RLHF, RLAIF, PPO, GRPO, RL with verifiable rewards, or related methods (strongly preferred)
• Supervised fine-tuning, full-parameter fine-tuning, parameter-efficient fine-tuning (LoRA), or related methods
• Systematic hyperparameter optimization or large-scale experimentation using tools such as Optuna, Ray Tune, or similar frameworks
• Strong engineering practices: reproducible experimentation, clean code, testing, and performance-aware debugging
• Comfort with modern ML infrastructure (e.g., Docker, CUDA, Kubernetes, experiment tracking tools such as Weights & Biases)

Preferred

• Experience with multimodal or multi-task model architectures
• Training and inference optimization (e.g., mixed precision, kernel optimization, quantization, distributed strategies)
• Familiarity with biomedical, chemical, or biological data domains
• Distributed training at scale
• HPC or large-scale training operations experience

About Iambic Therapeutics

Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need.

MISSION & CORE VALUES

Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.

Pay And Benefits

We offer a competitive compensation package, private medical insurance, life assurance, pension contributions, and flexible holiday allowances to our team. Our UK office provides a modern and collaborative work environment, right in the centre of Bristol.