Manager - Biologics And Mammalian Expression in Bath

An exciting opportunity for a Senior Technical Manager to join a leading biologics development organisation based in a science-driven environment. This role offers a unique chance to provide high-level technical leadership and strategic direction within a biologics‐focused setting, supporting innovative programmes of work that push the boundaries of bioprocessing and biologics manufacturing.

Our client is seeking an experienced and visionary leader to manage a multidisciplinary team responsible for upstream biologics production, ensuring delivery of complex projects and continuous process improvement. The successful candidate will play a key role in shaping the future of biologics development by translating technical breakthroughs into operational success, all while fostering a high-performance, collaborative culture.

• Lead and direct the Synthetic and Mammalian Upstream Team, ensuring the effective delivery of a diverse project portfolio aligned with the organisation's strategic goals.
• Act as the technical expert and project lead on complex biologics manufacturing projects, including expression system development, process validation, and scale-up/down activities.
• Manage, develop, and motivate a team of scientists and engineers, setting objectives, conducting performance reviews, and ensuring their continuous technical and professional growth.
• Maintain and ensure compliance with all relevant SHE, GMP, Data Integrity, and quality standards, embedding best practices across all activities.
• Build and maintain relationships with external stakeholders, research organisations, and industry partners to facilitate collaborations, knowledge exchange, and business development opportunities.
• Act as a primary technical contact for clients and stakeholders during project delivery, providing expert advice and innovative solutions.
• Stay abreast of external developments in bioprocessing, gene and cell therapy technologies, and legislative changes, integrating new knowledge into team practices.
• Contribute to bid preparation and technical proposals, leveraging deep expertise to develop compelling value propositions.
• Ensure accurate documentation of technical data, methodologies, and decision-making processes in adherence to industry standards.

• A Degree or higher level in a Scientific discipline (e.g., Biochemistry, Cell Biology, Biological Sciences) plus relevant senior research or industrial experience.
• Proven expertise in upstream bioprocessing for biologics, including mammalian expression systems (such as CHO and HEK293) and recombinant protein production.
• Extensive practical experience with bioreactor scale-up, process optimization, and integrating analytical techniques like qPCR, SDS-PAGE, and ELISAs.
• Demonstrable leadership in managing multidisciplinary teams, fostering collaboration, and developing talent.
• Knowledge of GMP requirements for biopharmaceutical manufacturing and Data Integrity standards.
• Experience with high throughput bioreactor platforms and eukaryotic gene design, cloning, and transfection techniques.

This is more than a leadership role — it’s a chance to shape innovative biologics development in a state-of-the-art environment. You will have the opportunity to lead impactful projects, develop cutting-edge technologies, and work within a culture that values collaboration, growth, and scientific excellence. Our client offers a stimulating environment with opportunities for professional development, industry-leading facilities, and the chance to work at the forefront of biologics and gene therapy innovation.