Senior/Principal Bioinformatician

We are looking for a driven and experienced Senior or Principal Bioinformatician to lead the design and execution of bioinformatic analyses that support a variety of drug discovery initiatives. The role involves leveraging both public and proprietary large-scale patient, genomic, and functional datasets to guide and inform the company’s drug discovery priorities.

Key Responsibilities

• Provide innovative solutions to complex biological problems to gain new insights into multiple aspects of drug discovery.
• Collaborate with colleagues across the company to translate business needs into high value analysis in a timely fashion
• Work as a team to exploit and expand the data science infrastructure to meet business needs in a rapidly evolving environment.
• Expand and maintain internal bioinformatic tools.
• Work to achieve scientific deliverables and milestones at agreed quality and timescales. Identify and mitigate risks as they emerge.
• Establish appropriate communication with line manager, project team members and other stakeholders to ensure they are kept informed of workloads, issues, progress, results, innovation and developments.
• Actively demonstrate best practice and behaviours to create a positive, productive and inclusive working environment.
• Communicate analytical products and outputs to stakeholders.
• Seek input and feedback from internal and external stakeholders about their requirements and prioritize your workload.
• Interact with the Leadership team, project teams and external collaborators to aid in the delivery of projects.
• Contribute to the general duties of the company and pass on skills and knowledge to other team members.

Skills Required

[E = Essential D/E = Essential at Principal level D = Desirable]

Essential:

• A PhD in bioinformatics, pharmacology, molecular biology or related scientific discipline and/or experience in bioinformatics gained in academia or industry (E)
• Knowledge of cancer biology, cancer genomics, or cancer therapeutics (E)
• Experience of using bioinformatics tools to guide drug development in areas such as biomarker identification, patient selection, mechanisms of action and resistance (E)
• A track record of developing analytical solutions to complex biological problems (E)
• Advanced knowledge of programming in Python or similar (E)
• Experience in the integration, analysis and functional interpretation of omics experiments/datasets (transcriptomics, proteomics, CRISPR) (E)
• Experience using statistical testing, including hypothesis testing and power analysis (E)

Desirable for Senior Role, Essential for Principal Role:

• Experience in the analysis of large-scale genomic and functional genomic datasets through the use of automated workflows (D/E)
• Experience in analysis of clinical data analysis (D/E)
• Experience with cloud computing and software containerization (D)

Desirable:

• Knowledge of current software development methodologies e.g. Scrum/Agile, CI/CD, Concurrent Version Systems (e.g. Git) (D)
• Previous experience developing, deploying and maintaining software tools (D/E)
• Previous experience of developing, deploying and/or maintaining web user interfaces and/or REST APIs (D)

This is a hybrid role that requires 3 days on-site per week