At a Glance
- Tasks: Design and execute experiments in spatial transcriptomics and proteomics using cutting-edge technologies.
- Company: Leading research organisation in London with a focus on innovation and collaboration.
- Benefits: Competitive salary, state-of-the-art facilities, and opportunities for professional development.
- Other info: Inclusive environment that fosters curiosity and international collaboration.
- Why this job: Join a dynamic team and contribute to groundbreaking research in translational science.
- Qualifications: Ph.D. in relevant field with experience in spatial transcriptomics and FFPE tissue handling.
The predicted salary is between 30000 - 40000 £ per year.
We are seeking a highly motivated Scientist / Recent Ph.D Graduate with a background in Molecular Biology, Cell Biology, or a related field. The ideal candidate will have experience in spatial transcriptomics and proteomics, particularly using FFPE tissue samples, and a strong background in 10X Genomics library preparation for NGS. You’ll work in a fast-paced, collaborative environment, driving the development and optimization of cutting-edge spatial omics workflows in support of translational research and clinical discovery.
Key Responsibilities:
- Design, execute, and troubleshoot experiments using 10X Genomics Visium and related platforms for spatial transcriptomics.
- Process and analyze FFPE and fresh frozen tissue samples for transcriptomic and proteomic profiling.
- Prepare high-quality NGS libraries for Illumina sequencing, ensuring data integrity and reproducibility.
- Optimize protocols and workflows for challenging tissues (e.g., fibrotic, adipose, cartilage, bone).
- Collaborate with bioinformaticians, pathologists, and clinical researchers to interpret spatial omics data.
- Maintain accurate records, contribute to publications, and present findings at internal and external meetings.
Required Qualifications:
- Ph.D. in Molecular Biology, Cell Biology, Biotechnology, or related discipline with a focus on spatial transcriptomics or proteomics.
- Proven experience handling FFPE tissues for transcriptomic and protein-based methods.
- Expertise in 10X Genomics library preparation and workflows for NGS (e.g., Chromium, Visium).
- Familiarity with Illumina sequencing platforms and general NGS QC metrics.
- Experience working with difficult tissue types such as fibrotic, adipose, cartilage, or bone.
- Hands-on experience in single-cell technologies (e.g., scRNA-seq, CITE-seq) is a strong plus.
Preferred Skills:
- Strong understanding of tissue processing, histology, and immunostaining techniques.
- Excellent organizational and communication skills.
- Ability to work both independently and within cross-functional teams.
What We Offer:
- Competitive salary and benefits package.
- Access to state-of-the-art facilities and research platforms.
- Opportunities for professional development and international collaboration.
- A dynamic and inclusive working environment that supports innovation and curiosity.
RA- Tissue Profiling 12 month FTC in City of London employer: Hlx Life Sciences
Join a leading research institution in London, where you will be part of a dynamic and inclusive team dedicated to advancing the field of spatial omics. With access to state-of-the-art facilities and a strong emphasis on professional development, this role offers a unique opportunity to contribute to groundbreaking translational research while collaborating with experts across various disciplines. Experience a fast-paced work culture that fosters innovation and curiosity, making it an excellent place for recent Ph.D. graduates to thrive.
