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- Tasks: Conduct cutting-edge research on bacterial-fungal interactions using super-resolution microscopy.
- Company: Join Heriot-Watt University, a leader in innovative research and collaboration.
- Benefits: Enjoy 33 days of annual leave, competitive salary, and flexible working options.
- Why this job: Make a real impact in microbiology while developing advanced imaging skills.
- Qualifications: PhD in super-resolution microscopy or related field with hands-on experience required.
- Other info: Collaborate with a dynamic team and access state-of-the-art facilities.
The predicted salary is between 31900 - 39900 ÂŁ per year.
Salary: Grade 7 (ÂŁ37,694 - ÂŁ47,389)
Contract: Full‑Time (35 hours per week), Fixed Term until 27/08/2026
Holiday Entitlement: 33 days annual leave, plus 9 buildings closed days for all full time staff.
Purpose of this role
This Research Associate position will support cutting-edge research into Type VI secretion systems (T6SS) and their roles in bacterial–fungal interactions. This project will employ novel fluorescent protein tools to visualise how bacterial effector proteins are delivered into fungal cells. Using advanced single- and dual-colour single-molecule localisation microscopy (3D PALM and dSTORM), we will track individual effector molecules from their packaging within the secretion machinery, through firing and membrane penetration, to their final sites of catalytic activity. We will also investigate the downstream consequences of effector toxicity within fungal cells. The position is based primarily at Heriot‑Watt University in the laboratory of Dr Colin Rickman, offering hands-on experience with state-of-the-art super-resolution imaging through the facilities of the Edinburgh Super-Resolution Imaging Consortium (ESRIC). This role provides an excellent opportunity to develop expertise not only in advanced microscopy, but also in data processing, quantitative analysis, and modern imaging workflows.
Key Duties & Responsibilities
- Conduct research on T6SS effector delivery from bacteria into fungal cells.
- Employ engineered fluorescent proteins to visualise effector trafficking.
- Perform single- and dual-colour single-molecule localisation microscopy (including 3D PALM and dSTORM).
- Track effector proteins from packaging within the secretion machinery through to their catalytic sites in fungal cells.
- Investigate cellular responses and downstream effects resulting from effector-mediated toxicity.
- Contribute to data acquisition, processing, quantitative analysis, and documentation.
- Work collaboratively within the laboratory of Dr Colin Rickman at Heriot‑Watt University.
Essential & Desirable Criteria
Essential
- PhD in super-resolution microscopy, with specialisation in the development of fluorescent proteins, or a submitted PhD thesis in this area at the start of employment.
- Hands-on experience with single- and dual-colour PALM (Photoactivation Localisation Microscopy) in 2D and 3D.
- Demonstrated research track record in analysing Type VI secretion systems within bacterial–fungal co-cultures using advanced fluorescence microscopy.
- Ability to operate and troubleshoot both Olympus TIRF microscopes and Leica SP8 confocal microscopes independently.
- Proficiency in 3D deconvolution and localisation analysis using SVI Huygens software.
- Strong capability to design, manage, and progress research independently.
- Excellent communication skills, including high-quality written outputs and effective oral presentations.
- Proven ability to work collaboratively within a research team at Heriot‑Watt and with external scientific collaborators.
Desirable
- Demonstrable hands-on experience culturing bacterial and fungal cells, including establishing and maintaining bacterial–fungal co-cultures.
- Experience in live and fixed sample preparation specifically for super-resolution microscopy.
- Direct experience working with photoactivatable fluorescent proteins, both in vitro and in vivo.
- Direct experience of analysis of datasets using ImageJ, SVI Huygens and Imaris and figure generation using Graphpad Prism and Adobe Illustrator.
- Experience collaborating within multidisciplinary scientific teams, including effective work with external collaborators beyond the immediate research group.
How to Apply
Applications can be submitted up to midnight (UK time) on Wednesday 11th February 2026. Please submit your CV & covering letter via the Heriot‑Watt online recruitment. We welcome and will consider flexible working patterns e.g., part-time working and job share options.
Heriot‑Watt University is committed to securing equality of opportunity in employment and to the creation of an environment in which individuals are selected, trained, promoted, appraised, and otherwise treated on the sole basis of their relevant merits and abilities. Equality and diversity are all about maximising potential and creating a culture of inclusion for all. Heriot‑Watt University values diversity across our university community and welcomes applications from all sectors of society, particularly from under-represented groups.
About the Team
The Research Engagement Directorate provides high quality support for the Heriot‑Watt research community across three divisions: Research and Researcher Development, Legal, Policy, Strategy and Impact and the Research Futures Hub (incorporating the Graduate School). Working closely with the Business and Enterprise Directorate, RED works to deliver the Excelling in Research and Enterprise theme of Strategy 2025 and development of Heriot‑Watt’s new Strategy 2035.
About Heriot‑Watt University
At Heriot‑Watt we are passionate about our values and look to them to connect our people globally and to help us collaborate and celebrate our success through working together. Our research programmes can deliver real world impact which is achieved through the diversity of our international community and the recognition of creative talent that connects our global team. Our flourishing community will give you the freedom to challenge and to bring your enterprising mind and to help our partners with solutions that can be applied now and in the future. Join us and Heriot Watt will provide you with a platform to thrive and work in a way that also helps you live your life in balance with well-being and inclusiveness at the heart of our global community.
Research Associate in Super-resolution microscopy employer: Heriot-Watt University Malaysia
Contact Detail:
Heriot-Watt University Malaysia Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Research Associate in Super-resolution microscopy
✨Tip Number 1
Network like a pro! Reach out to your connections in the field of super-resolution microscopy. Attend relevant conferences or seminars, and don’t be shy about introducing yourself to researchers at Heriot-Watt University. You never know who might have a lead on the perfect opportunity!
✨Tip Number 2
Show off your skills! Prepare a portfolio showcasing your hands-on experience with single- and dual-colour PALM and any other relevant projects. This will not only impress potential employers but also give you confidence during interviews.
✨Tip Number 3
Practice makes perfect! Conduct mock interviews with friends or mentors to refine your communication skills. Focus on explaining complex concepts clearly, as this is crucial for roles involving advanced microscopy techniques.
✨Tip Number 4
Apply through our website! It’s the best way to ensure your application gets noticed. Tailor your CV and cover letter to highlight your expertise in T6SS and fluorescence microscopy, and make sure to emphasise your collaborative spirit!
We think you need these skills to ace Research Associate in Super-resolution microscopy
Some tips for your application 🫡
Tailor Your CV: Make sure your CV is tailored to highlight your experience in super-resolution microscopy and any relevant research on Type VI secretion systems. We want to see how your skills align with the role, so don’t hold back!
Craft a Compelling Cover Letter: Your cover letter is your chance to shine! Use it to explain why you’re passionate about this research area and how your background makes you a perfect fit for our team. Keep it engaging and personal.
Showcase Your Skills: Don’t forget to mention your hands-on experience with microscopy techniques like PALM and dSTORM. We love seeing specific examples of your work, so include any projects or results that demonstrate your expertise.
Apply Through Our Website: Remember to submit your application through the Heriot-Watt online recruitment portal. It’s the easiest way for us to review your application and get you into the process. Good luck!
How to prepare for a job interview at Heriot-Watt University Malaysia
✨Know Your Microscopy Inside Out
Make sure you brush up on your knowledge of super-resolution microscopy techniques, especially 3D PALM and dSTORM. Be ready to discuss your hands-on experience with these methods and how you've applied them in your research.
✨Showcase Your Research Track Record
Prepare to talk about your previous research involving Type VI secretion systems and bacterial-fungal interactions. Highlight specific projects, your role, and the outcomes to demonstrate your expertise and ability to contribute to the team.
✨Communicate Clearly and Confidently
Practice articulating your thoughts clearly, especially when discussing complex scientific concepts. Good communication skills are essential, so consider doing mock interviews or explaining your research to a friend to build confidence.
✨Be Ready for Collaboration Questions
Expect questions about teamwork and collaboration, as this role involves working closely with Dr Colin Rickman and other researchers. Prepare examples of how you've successfully collaborated in the past and how you can bring that experience to the new role.