VP Medicine Development Leader- Oncology

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting‑edge technology to transform people’s lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients’ needs and have the highest probability of success.

The VP Medicine Development Leader (MDL) is to strategically lead the optimal global development of a medicine, acting as the single point of accountability for the medicine from C2P2 to approval in first major market, but substantially contributing and influencing from pre‑C2P2 to post‑launch life‑cycle management, to ultimately deliver differentiated medicines of value.

By working with the various stakeholders across R&D and Pharma, the MDL defines the strategic vision and operational plan for the medicine, aligning it with the overall organizational strategy. The VP MDL creates and leads the matrix Medicine Development Team (MDT), which has responsibility for representing all the various R&D and commercial disciplines required to optimally deliver the development of the medicine (including clinical development, medical affairs, safety, regulatory, commercial and product development and manufacturing, amongst others).

Please note: This position requires an on‑site office‑based presence 2 to 3 days a week in the UK (London or Stevenage) or US (Collegeville/Upper Providence, PA or Waltham, MA).

Responsibilities

• Act as a single point of accountability in GSK for all aspects of a medicine in development globally from C2P2 to approval in first major markets.
• Provide key support to the Early Development Team (EDT) leading up to C2P2 to ensure smooth transfer of accountability and a successful C2P2 and transition from phase 1 to phase 2.
• Provide key support to the Medicines Commercialisation Team post‑approval in first major markets ensuring that the MDT provide optimal support to both registration and lifecycle management.
• Select members of the MDT, in consultation with the line leaders, and lead this multi‑disciplinary matrix team; support differentiated development for team members; own the performance of MDT and partner with line managers to drive performance.
• Establish a compelling vision for the medicine; position the medicine within the R&D strategy taking the competitive landscape into account; translate GSK’s strategy into asset strategy and actionable plans for multiple areas or functions.
• Deliver differentiated medicines of value for patients, stakeholders and markets, through an evidence package that supports regulatory approval, market access, and product life cycle.
• Deliver the Medicine Development Strategy that is aligned with the R&D disease strategy, as well as the asset Medicine Vision and Medicine Profile.
• Prioritise and maximise the asset’s portfolio options including developing multiple indications.
• Make clear evidence‑based go / no go / accelerate decisions, based on whether the results fulfil the strategy set out for the medicine, and identify clear inflection points.
• Embed core processes including cost efficiency, adoption of new technology, risk identification & management, compliance with policy.
• Identify and align resources (people and financial), team objectives and strategies behind the vision to ensure successful project completion.
• Proactively identify unmet medical needs that could be addressed through line extensions.
• Enhance patient focus by incorporating the voice of the patient into development plans.
• Promote organizational reputation and drive asset value by engaging and negotiating with internal and external stakeholders.
• Collaborate with other stakeholders but in particular EDLs and other MDLs to create strategies that support organizational vision; share optimal ways of working and knowledge.
• Ensure quality & compliance oversight in line with R&D expectations and project needs; assure quality of data and science.
• Prioritise and manage asset portfolio options to meet budget constraints.
• Model Values and Leadership Expectations internally and externally.
• Serve as the single point of contact and spokesperson to senior management and senior boards and other relevant internal governance committees and external Advisory Committees as needed.
• Increase visibility amongst the external communities (physicians, regulators, patients, payers), to bring medical solutions to patients with unmet medical needs, thereby enhancing reputation of GSK.
• Serve as the single accountable decision maker to resolve disputes among the MDT.
• Accountable for delivering and managing the asset resourcing plan and managing the asset budget to the agreed variance.
• Accountable for developing an ongoing patent strategy for the asset.
• Partner with Business Development to facilitate diligence reviews, product positioning and/or alternative business strategies and internal review and decision‑making processes in line with GSK governance procedures.

Basic Qualifications

• Advanced degree in a clinical or scientific discipline (MD, PhD, PharmD or equivalent).
• Filing experience BLA/NDA/MAA submissions as a core responsibility and have led development programs.
• Must demonstrate extensive broad drug development expertise and experience.
• Executive level pharmaceutical industry experience.
• Prior significant experience in leading successful development and registration of medicines.
• Deep experience in product development and/or commercial, especially in late phase Oncology development (from PoC onwards), clinical trial management with significant operational complexity, post‑approval studies, regulatory and manufacturing compliance.
• Highly developed ethics and integrity, with demonstrated ethical medical decision‑making skills.
• Understands the entirety of R&D across the development/commercial life cycle to allow impact across all functions: discovery, late stage development, regulatory, manufacturing and commercial.
• Track record of success working in highly complex, matrixed, global, and multi‑disciplinary organization with high accountability, minimal authority, and multiple lines of reporting.
• Experience working with regulators and regulatory requirements including an understanding of the legal and government frameworks within and across global geographies.
• Strong people management, leadership and motivational skills.
• In‑depth experience creating the strategy for pre‑ and post‑marketing studies, and driving the lifecycle process.
• Ability to work collaboratively and successfully across functions – research, commercial, regulatory, global medicine supply, legal, regions, etc.
• Ability to build relationships and create authentic alignment while leading high performing teams in a collaborative and purposeful manner to achieve defined objectives.
• Must be able to clearly demonstrate a thorough understanding of the healthcare environment including all key external stakeholders.

Preferred Qualifications

• Business acumen and experience of managing a sizable P&L which has organizational impact.
• Experience of building budgets and then leading the strategic and budget planning process.
• Track record of leading with high operational complexity.

If this role inspires you, please apply. We welcome applicants from all backgrounds and lived experiences. We are committed to inclusion and to creating a workplace where people can be themselves and do their best work.

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive.

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.