Molecular Design Engineer

This job is with GSK, an inclusive employer. We create a place where people can grow, be their best, be safe, and feel welcome, valued and included. We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme. We embrace modern work practices; our Performance with Choice programme offers a hybrid working model, empowering you to find the optimal balance between remote and in-office work.

Are you a forward-thinking scientist passionate about bridging the gap between computational design and experimental work? Within the Large Molecule Research (LMR) department at GSK, we are pivoting from traditional wet-lab process-reliant sequence generation to a pioneering, AI-driven computational design paradigm. We are seeking a diligent and motivated Molecule Design Engineer to join our Antibody Engineering team within the Molecular Design and Engineering (MDE) section. Positioned at the interface of molecular design, structural biology, and property prediction, you will drive optimization of biopharmaceuticals.

In this highly collaborative role, you will bridge wet-lab molecular biology and the cutting-edge predictive tools provided by our partners. By owning our in silico risk-scoring systems, evaluating predictive models with real-world experimental data, and leading targeted engineering efforts, you will directly shape the developability of GSK's next generation of life-changing biopharmaceuticals.

In this role you will:

• Work within the GSK project portfolio:
• Identify risks and liabilities in early-stage biologics using predictive models and sequence and structure analysis.
• Interpret the impact of identified risks on project progression.
• Mitigate risks by designing de-risked, more developable variants, including complex antibody formats such as multispecifics.
• Deliver the DNA required to express designed molecules.
• Advance technologies within Large Molecule Research:
• Act as a liaison between Large Molecule Research and computational teams developing predictive models and deploying them on GSK IT infrastructure.
• Evaluate predictive models using experimental data.
• Develop in silico risk-scoring systems and interpret how identified risks may affect molecule progression.
• Design and run engineering strategies to mitigate identified risks.
• Build and maintain computational tools, such as dashboards, to support these activities.

Essential skills:

• Experience in antibody discovery and/or design, with a strong understanding of how antibody sequence and structure influence function and developability.
• Experience with, or knowledge of, bispecifics and other complex antibody formats.
• Skilled in designing expression constructs and plasmids.
• Experience navigating complex data systems, analysing datasets, and using data to support model building, molecule design, and decision-making.
• Skilled in using AI tools (Copilot, Claude), generating Python scripts, SQL queries, using BigQuery, Spotfire or similar software, and working in cloud-based environments such as Google Cloud Platform (GCP).
• Excellent communication and stakeholder involvement within complex matrix project teams.

Nice to have:

• Experience in protein/antibody modelling and interpretation of the structure data.
• Application of AI for biologics discovery and optimization.

This role will temporarily be based at Stevenage. However, the Company plans to relocate its offices to Cambridge. The location of this role will therefore subsequently change to Cambridge in accordance with timelines to be set by the Company. The relocation is currently proposed to take effect by early 2029.

Why GSK? Uniting science, technology and talent to get ahead of disease together. GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases - to impact health at scale.

People and patients around the world count on the medicines and vaccines we make, so we're committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.