Director Clinical Pharmacology in London

This role is based in the UK or US, with remote working or placement at other European GSK sites possible for the right candidate.

The Director, Clinical Pharmacology sits within the newly established Clinical Pharmacology and Quantitative Medicine (CPQM) organisation, which aims to be a centre of excellence in Model‑Informed Drug Development (MIDD) by integrating clinical pharmacology, digital medicine, translational imaging and mechanistic/systems modelling.

Main responsibilities

• Design & Execute Model Informed and Clinical Pharmacology strategies: Develop and implement robust MIDD & ClinPharm evidence strategies to de‑risk and accelerate RIIRU programmes, aiming for faster development, optimal dosing and stronger regulatory positioning across respiratory, inflammation, neurodegeneration and emerging areas, and supporting business development opportunities.
• Ensure robust ways of working and regulatory‑ready evidence: Draft and review clinical pharmacology regulatory content to support timely approvals and optimal labelling, maintaining up‑to‑date knowledge of FDA, EMA, CDE, PMDA and ICH expectations and embedding regulatory considerations into study design and MIDD strategies.
• Build cross‑functional partnerships: Work closely with CPQM peers (digital medicine, translational imaging, MIDD specialists, mechanistic/systems modelling) and cross‑functional partners (biology, data science, computational biology, clinical, etc.), maintaining strong networks and sharing best practices within the CPMS community of practice.
• External engagement & scientific leadership: Raise GSK’s profile in MIDD, clinical pharmacology, QSP and AI/ML integration through publications, conference presentations and active participation in scientific and regulatory fora to influence method adoption and regulatory dialogue.

Basic Qualifications

• PhD in life sciences or related discipline, MD, or PharmD, with experience in clinical pharmacology, modelling and simulation in pharmaceutical research and development.
• Significant experience in clinical pharmacology, modelling/simulation and drug development to solve practical problems in the pharmaceutical industry.
• Experience in pharmacometrics and their application to clinical questions in drug development.

Preferred Qualifications

• Additional experience in respiratory and immunology would be beneficial.
• Demonstrated experience of collaboration in a multi‑discipline team, using effective communication and taking personal accountability for timely delivery of results.
• Evidenced experience making sound judgement in complex situations and adapting to changing business needs by prioritising multiple tasks.
• Experience working with senior stakeholders in a cross‑functional environment.
• Track record of implementation of Model‑Informed Drug Development (MIDD) approaches to accelerate patient access to novel therapies and expand therapeutic indications of marketed drugs.
• Drive and learning agility to build knowledge on a drug‑disease system, symptom progression, standard of care and trial design.

Compensation & Benefits

For candidates based in Cambridge, MA; Waltham, MA; Rockville, MD; or San Francisco, CA, the annual base salary ranges from $188,100 to $313,500. In addition, this position offers an annual bonus and eligibility to participate in GSK’s share‑based long‑term incentive programme. Available benefits include health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave.

EEO Statement

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, colour, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.