Executive Medical Director/Clinical Development Lead, GU

For candidates seeking to be located at our Stevenage site, this role will temporarily be based at Stevenage. However, the Company plans to relocate its offices to Cambridge, UK. The location of this role will therefore subsequently change to Cambridge, UK in accordance with timelines to be set by the Company. The relocation is currently proposed to take effect by early 2029.

Cancer is unrelenting, but so are we. At GSK, we are committed to transforming outcomes for people with cancer through innovative science, bold ambition, and strong partnerships across the healthcare ecosystem. We focus our science where it can matter most — advancing care in cancers with high unmet need, grounded in a deep understanding of disease biology and deliberate scientific choices that connect discovery to meaningful impact in the real world.

With GSK's growing portfolio in GU (genitourinary) cancers, we have an exciting opportunity for a Clinical Development Lead (CDL) – Oncology GU. Operating at the asset level as the enterprise clinical strategy leader, you will be accountable for defining the clinical strategy, scientific narrative, and decision framework across the asset lifecycle. The CDL serves as a full strategic partner within the Medicine Development Team (MDT) core quad, positioning Clinical Development at the centre of product strategy, governance, and investment decisions.

The CDL owns the clinical roadmap and serves as the recognised clinical authority and visible leader for the asset’s strategic vision, shaping how clinical strategy, scientific insight, development innovation, and decision velocity are understood and experienced across the organisation, representing Clinical Development in both internal and external settings. You will be accountable for the strategic direction and clinical positioning of the asset, with operational study-level delivery led by Senior Scientists within the programme. This role is critical to enabling a more dynamic, data-driven, and technology-enabled model of clinical development, increasing speed, precision, and decision quality.

In This Role You Will:

• Define and own the clinical strategy, scientific narrative, integrated benefit–risk position, and decision framework across the asset, ensuring a coherent and differentiated clinical position throughout the lifecycle.
• Accountable for strategic outcomes across the asset, with study-level delivery, including design, execution, and data generation, led by Senior Scientists and programme teams within the CDL’s strategic direction.
• Serve as the senior clinical strategy leader on the MDT core quad, acting as a full strategic partner to the Medicine Development Leader (MDL) and representing Clinical Development in portfolio, governance, and investment decisions.
• Lead or co-lead governance and investment presentations to senior management, translating clinical evidence into clear strategic recommendations for portfolio prioritisation and progression.
• Serve as the recognised clinical authority and visible leader for the asset, ensuring its clinical vision, scientific identity, and development trajectory are clearly understood and advanced across the organisation.
• Drive an integrated, end-in-mind approach to development, ensuring that target selection, development pathways, regulatory positioning, and commercial readiness are considered as a connected whole.
• Act as the default Clinical Development representative for Health Authority interactions, advisory boards, steering committees, IDMCs, and alliance partnerships.
• Leverage AI-enabled insights, advanced analytics, and emerging data platforms to inform asset-level strategic decisions and drive competitive advantage in development speed and decision quality.
• Lead, develop, and mentor clinical development talent, contributing to talent calibration, succession planning, and capability building aligned to evolving development models.

Key Responsibilities:

• Enterprise Clinical Strategy and Governance
• Clinical Development Plan and Benefit–Risk Leadership
• Scientific Leadership and External Engagement
• People Leadership and Capability Development

Basic Qualifications:

• MD, PharmD, PhD, or equivalent advanced degree required (MD strongly preferred).
• Minimum 10 years’ pharmaceutical or relevant scientific, medical, or clinical experience, with at least 7 years in oncology clinical development.
• Evidenced strong disease area knowledge in GU malignancies, specifically bladder cancer.
• Demonstrated experience operating at the asset, portfolio, or enterprise level, including governance and investment decision-making.
• In-depth knowledge of GCP, ICH, FDA, EMA, NICE, and relevant regulatory frameworks.
• Proven ability to lead and influence cross-functional teams in complex matrix environments.
• Strong understanding of clinical development, oncology therapeutic landscapes, and drug approval processes.
• Experience leveraging data, advanced analytics, or emerging technologies to inform clinical decision-making.

Preferred Qualifications:

• Experience leading or co-leading Health Authority interactions.
• Board certification, eligibility, or substantive clinical experience in oncology.
• Strong executive presence and enterprise influencing capability.
• Experience translating clinical data into strategic decisions across development and lifecycle.
• Cross-functional business acumen across clinical, regulatory, commercial, and access domains.

Closing date for applications: 13 November 2026

Working Arrangement: This role is hybrid. You will be on-site at one of the posted locations at least two days per week. Remote work is available on other days.

Skills: Clinical Data Interpretation, Clinical Trial Designs, Clinical Trials Monitoring, Digital Fluency, Drug Development, Drug Regulatory Affairs, Evidence Based Decision Making, Executive Presence, Hematology and Oncology, Learning Agility, Matrix Leadership, Real World Evidence (RWE), Scientific Presentations, Strategic Direction.

If you require an accommodation or other assistance to apply for a job at GSK, please contact the appropriate Recruitment Staff by emailing us at - usrecruitment.adjustments@gsk.com.

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.