Clinical Development Senior Medical Director - Vascular

This job is with GSK, an inclusive employer and a member of myGwork – the largest global platform for the LGBTQ+ business community.

For candidates seeking to be located at our Stevenage site, this role will temporarily be based at Stevenage. However, the Company plans to relocate its offices to Cambridge, UK. The location of this role will therefore subsequently change to Cambridge, UK in accordance with timelines to be set by the Company. The relocation is currently proposed to take effect by early 2029.

Working model: This role is hybrid. You will be on-site at one of the posted locations at least two days per week. Remote work is available on other days.

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people's lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients' needs and have the highest probability of success. We're uniting science, technology, and talent to get ahead of disease together.

Position Summary: You will lead clinical development medical activities for vascular programmes across early and later phase studies. You will work closely with colleagues in clinical operations, translational science, regulatory, safety, and commercial teams. We value clear clinical judgement, collaborative leadership and a focus on patient impact. You will shape clinical plans that accelerate safe, meaningful medicines to people with vascular disease while growing your career and influence at GSK.

This role will provide YOU the opportunity to lead key activities to progress YOUR career. These responsibilities include some of the following:

• Lead the formulation of translational and clinical plans and study designs with project strategies to ensure quality design and execution of the CDP. Develop sections of core regulatory documents.
• Generate the data and evidence required to determine a target's potential efficacy, safety profile, key areas of differentiation and route to becoming a medicine with value to patients in the shortest possible timeframe.
• Define and deliver the clinical pillars of the translational table. Deliver clinical development and study timelines and endpoints, including pharmacology, mechanism and clinical efficacy endpoints, enabling key decision points and go/no-go criteria for the CDP.
• Establish and maintain relationships with program counterparts in biology, translational sciences, commercial, regulatory, clinical operations, market access, medical affairs and statistics.
• Contribute to the implementation and embedding of strategic initiatives and various organizational initiatives in Clinical Development.

Clinical Development Strategy and Study & Program Design:

• Provide effective and experienced support and oversight of R&D evidence generation strategy, plan and activities to ensure patient safety and on-time, in-full study delivery.
• Contribute to the study team discussions on indication planning and incorporate input from across disciplines (scientific, clinical, commercial, regulatory, stats, etc.) to contribute to vital deliverables including early medicine profile, target validation, translational plans, candidate selection.
• Lead the design of clinical development plans, study protocols and associated documents across all phases of development, reflecting internal and external stakeholder input (e.g., patients, evidence generation, regulators, payors, pharmacovigilance), with an emphasis on early development.
• Bring clinical expertise to regulatory interactions and documents including briefing documents, presentations, addressing questions and responses for assigned studies and programs.
• Provide medical monitoring and oversight of the safety of study participants on behalf of the sponsor during the study, together with pharmacovigilance physician. You will be accountable for medical governance across the project to ensure scientific integrity and overall safety of the study subjects across the study.

Clinical Leadership:

• Accountable for leading the clinical matrix team (CMT) for a program. Serve as a clinical point of contact both internally and externally for an indication of an asset or for a clinical study, and represent the CMT at early/medicine development teams.
• Actively lead the end-to-end clinical development strategy for an early program and may contribute to later stages.
• Serve as the primary clinical point of contact for an investigational agent (early development) or clinical study for internal and external stakeholders, including regulatory agencies, key opinion leaders, and clinical investigators and with the relevant internal review boards (e.g., technical review or governance) and/or Protocol Review Board.
• Lead clinical evaluation of business development opportunities.
• Remain abreast of advancements in research, clinical trial methodologies, competitive environment and regulatory space in the relevant disease area to maintain GSK's competitive edge, and disseminate information about recent advances to the relevant GSK colleagues.

Why You?

Basic Qualification: We are seeking professionals with the following required skills and qualifications to help us achieve our goals:

• Medical degree
• Board registration/certification/eligibility in cardiovascular medicine disease, vascular medicine or related specialty.
• Minimum of 5 years of experience in clinical research and development.
• Knowledge of and experience in the execution of translational studies including both generation and analysis of human translational data and conduct of preclinical biological experiments in relevant model systems.
• Robust knowledge of cardiovascular medicine research priorities, public health needs, competitor landscape, clinical practice trends and treatment guidelines evolution.
• Experience working with global regulatory agencies and managing global clinical trials in relevant disease area.
• Knowledge of regulatory requirements, Good Clinical Practice (GCP), and ethical guidelines for clinical research.
• Demonstrated ability to work collaboratively in cross-functional teams and a matrix environment to design and execute trials to regulatory standards.

Preferred Qualifications:

• PhD in addition to medical degree.
• Experience in contributing to IND/CTA, NDA, BLA, or MAA submissions preferred.

What we value in you: We value people who put patients first, act with integrity and work collaboratively. We want colleagues who apply clear clinical judgement, communicate honestly, and focus on delivering high-quality results. You will join a team that supports your development and gives you space to grow professionally while making a tangible difference to patient care.

How to apply: If this role speaks to you, please apply with your CV and a short note describing a clinical development or safety activity you led and the impact it delivered. If you need reasonable adjustments to apply or interview, tell us and we will support you. We welcome candidates from many backgrounds and encourage you to apply.

Skills: Clinical Development, Communication, Drug Regulatory Affairs, Evidence Based Decision Making, Good Clinical Practice (GCP), Influencing Without Authority, Learning Agility, People Management, Project Management, Scientific Presentations, Strategic Thinking.

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases - to impact health at scale.

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.