Cardio-Renal Discovery Disease Area Lead in Cambridge

We create a place where people can grow, be their best, be safe, and feel welcome, valued and included.

We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme.

We embrace modern work practises; our Performance with Choice programme offers a hybrid working model, empowering you to find the optimal balance between remote and in-office work.

Discover more about our company wide benefits and life at GSK on our webpage Life at GSK | GSK

Discovery Disease Area Lead, Cardiovascular-Renal Diseases

At GSK, we are dedicated to improving the quality of human life by leveraging scientific advancements to develop better medicines with reduced attrition. Through our Discovery Disease Area Leads (DDALs), we enable target identification, selection, and validation at scale, driving innovation and excellence across our R&D landscape.

As the Discovery Disease Area Lead, Cardiovascular-Renal, you will be at the forefront of our mission, driving the discovery and validation of therapeutic targets for a range of diseases, such as chronic kidney disease, glomerulonephritis and cardiovascular conditions that are associated with metabolic dysfunction. You will lead a cross-functional, highly matrixed team of scientists, clinical staff, and pharma experts to identify and validate high-quality targets using large-scale experimental and in silico approaches. Your efforts will ultimately contribute to translating human disease phenotype information into actionable therapeutic innovations.

Location: This role will be based at one of GSK's R&D hub sites, in Stevenage, UK, or Upper Providence, PA, USA. The Discovery Disease Area Lead, Cardiovascular-Renal will be expected to spend at least 2-3 days / week on site.

For candidates seeking to be located at our Stevenage site, this role will temporarily be based at Stevenage. However, the Company plans to relocate its offices to Cambridge, UK. The location of this role will therefore subsequently change to Cambridge, UK in accordance with timelines to be set by the Company. The relocation is currently proposed to take effect by early 2029.

Key Responsibilities:

Portfolio Execution -

• Portfolio Generation and Oversight: Generate and oversee the pre-Commit to Target (C2T) project portfolio in the Renal and Cardio-Renal therapy area.
• Target Delivery: Systematically deliver pools of high-potential targets that fulfill all C2T quality criteria based on therapeutic area-defined target medicine profiles for bespoke target validation
• Senior Management Interface: Influence Senior R&D management by identifying and communicating portfolio risks and opportunities.
• Strategy Execution: Drive development and implementation of key components of the renal and cardio-renal research strategy in R&D Tech for the Research Units.
• Team Representation: Ensure appropriate representation of lines/functions within the operational matrix team.

Cardiovascular / renal / metabolic disease expertise

• Nephrology and/or Cardiovascular Expertise: Apply deep experience in renal and cardio-renal disease indications drug discovery, focusing on clinically relevant target identification through human-first discovery approaches.
• Scientific Excellence: Drive best-in-class science across R&D Technologies and Research Units (RUs).
• Strategic Partnership: Partner proactively with Research Units and R&D Technology Leadership to provide strategic scientific input into disease phenotype discovery and therapeutic target identification.
• External Engagement : Maintain connection with renal biology experts, KOLs, and societies to ensure solid strategic guidance on emerging therapeutics, understanding which could impact the portfolio and priorities.
• Clinical Insight: General understanding of clinical treatments for renal, cardio-renal and associated diseases and emerging innovative trial design and biomarkers.
• Business Case Development: Lead the creation of strong business cases that align with RU and R&D Tech strategies.
• External Opportunities Assessment: Collaborate with Business Development to assess external opportunities.

Strategic Alignment -

• Framework Adherence: Ensure adherence to decision frameworks up to C2T, incorporating relevant stakeholders.
• Resource Coordination: Coordinate resources from RDTech and RUs to cover all steps from the patient identification, strategic ideation, target screening, triage, large-scale validation, and presentation.
• Risk Management: Elevate resource challenges, project risks, pipeline risks, and opportunities to RDTech LT.
• Resource Allocation: Make recommendations to department heads (RDTech and RUs) on areas to reduce, postpone, or stop.

Why you?

Basic Qualifications & Skills:

We are looking for professionals with these required skills to achieve our goals:

Education: Minimum of PhD degree or extensive (15+ years) drug discovery and development experience.

Experience: Minimum of