Associate Director, Quantitative Systems Pharmacology

Overview

The Department of Clinical Pharmacology and Quantitative Medicine (CPQM) in Respiratory, Immunology and Inflammation Research Unit conducts simulations to assess trial design performance. Utilise mechanistic models of biological, physiological, and pathophysiological processes to evaluate a disease, its pathways and progression, as well as drug candidates or treatment modalities.

Develop and/or utilise state-of-the-art mathematical tools including knowledge of inverse-problem modelling and simulation, scientific ML and/or statistical techniques to gain insight into causal relationships between individual components of system-level and drug-level responses of drug-target-biomarker-disease-patient interaction.

Facilitate defining and executing a coordinated scientific and technical strategy (18-24 months planning horizon) with demonstrated ability to co-ordinate outputs from several expertise areas to determine strategy. Work in close collaboration with biologists, clinicians, clinical pharmacologists, pharmacometricians, statisticians, AIML, imaging, biomarker and other partner line colleagues to inform research and development programmes and improve our understanding of disease mechanisms.

Implement best practices, trends, lessons learned from internal and external sources to further clinical pharmacology modelling and simulation contributions to oncology, HIV, and infectious diseases - to impact health at scale.

People and patients around the world count on the medicines and vaccines we make, so we’re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.

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