Associate Director, PBPK-PD Translational Modeling, DMPK

This job is with GSK, an inclusive employer.

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people’s lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing.

We have an exciting opportunity for a scientifically ambitious Associate Director to join the PBPK-PD Translational Modeling group within DMPK. The role focuses on developing and applying mechanistic PBPK-PD models for oligonucleotide therapeutics and antibody-drug conjugates, translating in vitro and preclinical data into predictions of tissue exposure, target engagement, and pharmacological effects in patients. Experience in T-cell and myeloid cell engager modelling is advantageous.

You will provide PBPK-PD expertise to support target validation, modality selection, human dose prediction, and PK/PD strategies from early discovery through first-in-human studies. The role also involves integrating PBPK-PD, QSP, and AI-enabled modelling approaches to drive data-informed candidate selection and development decisions.

This role is offered on a hybrid basis (UK or US), with an expectation of typically 2 to 3 days per week on-site and flexibility according to business needs and local policy.

Responsibilities

• Translational PBPK-PD modeling for Biologic Modalities
• Building, qualifying and applying mechanistic whole-body PBPK-PD models for siRNA, ASO and conjugated oligonucleotides
• Building and applying ADC PBPK models integrating antibody disposition, target expression and internalization, DAR distribution and deconjugation, linker stability, payload release and intratumoral penetration including bystander effects
• Delivering human efficacious dose projections — translating preclinical PK/PD into clinical dose, regimen and duration with explicit treatment of uncertainty and driving assumptions
• Defining project-level PK/PD modeling strategies and articulating them to project teams and governance bodies
• Creating opportunities to apply integrated PBPK-PD and QSP approaches earlier in discovery
• Partnering with Discovery, Biology, Chemistry, Toxicology, Bioanalysis and Clinical Pharmacology to embed model-informed drug discovery and development (MID3) into the standard progression path and define quantitative candidate selection criteria
• Applying AI/Tech-enabled modeling frameworks is essential to this role
• Engaging line and middle management, project teams and external partners at functional, strategic and tactical level, and representing DMPK modeling at internal forums and project team meetings
• Promoting external credibility through peer-reviewed publications and conference presentations.

Basic Qualifications

• PhD in pharmacokinetics, pharmaceutical sciences, chemical or biomedical engineering, systems pharmacology, applied mathematics, statistics or a closely related quantitative discipline.
• Strong experience developing and applying mechanistic PBPK and/or PK-PD models in an industry or equivalent research setting, with verifiable proficiency in PBPK and systems modeling platforms (e.g. Simcyp, SimBiology/MATLAB, etc.).
• Demonstrated experience delivering human PK and efficacious dose predictions and translational PK/PD assessments.
• Demonstrated ability to apply AI/Tech-enabled modeling frameworks.

Preferred Qualifications

• Direct experience modeling oligonucleotide and antibody-drug conjugates or other bioconjugates
• Track record of implementing MID3 approaches to accelerate progression of novel therapeutics and to strengthen the quality of portfolio decisions
• Demonstrated aptitude for productive collaboration in a multi-disciplinary matrix team, with effective communication and personal accountability for timely delivery.

How to apply

We welcome applicants at different stages of their careers. Please send your CV and a short cover letter describing a recent PBPK-PD or translational modelling project that had clear impact. Tell us what you modelled, the decisions you supported, and what you learned. If this role fits your skills and purpose, please apply. We look forward to hearing from you.

Why GSK?

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive.

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.