Associate Director / Director, Quantitative Systems Pharmacologist Lead

The Department of Clinical Pharmacology and Quantitative Medicine (CPQM) in the GSK Respiratory, Immunology and Inflammation Research Unit is recruiting a Quantitative Systems Pharmacologist Lead for the Quantitative Systems Pharmacology team. CPQM is a newly established organization focused on becoming a Centre of Excellence in Model-Informed Drug Development. The role integrates clinical pharmacology, digital medicine, translational imaging, and mechanistic and systems modeling.

Responsibilities

• Build and/or guide mathematical model development to understand disease, its progression, and drug action to prevent, treat and cure diseases; conduct simulations to assess trial design performance.
• Apply mechanistic models of biological, physiological, and pathophysiological processes to evaluate a disease, its pathways and progression, as well as drug candidates or treatment modalities.
• Develop and/or utilize state-of-the-art mathematical tools including knowledge of inverse-problem modelling and simulation, scientific ML and/or statistical techniques to gain insight into causal relationships between individual components of system-level and drug-level responses of drug-target-biomarker-disease-patient interaction.
• Define and execute a coordinated scientific and technical strategy (18‑24 months planning horizon) with demonstrated ability to coordinate outputs from several expertise areas to determine strategy.
• Work in close collaboration with biologists, clinicians, clinical pharmacologists, pharmacometricians, statisticians, AIML, imaging, biomarker and other partner line colleagues to inform research and development programs and improve our understanding of disease mechanisms.
• Implement best practices, trends, lessons learned from internal and external sources to further clinical pharmacology modelling and simulation contributions to R&D pipeline.
• Create a collaboration framework with internal and external experts in the development and application of these models.
• Learn and apply emerging modeling and simulation methodologies with a view to enhance clinical program efficiency and investment decision quality; collaborate with external field‑leading teams for methodology application.
• Able to efficiently and effectively interact with line and middle management, staff and external contacts on a functional, strategic and tactical level.
• Represent QSP CPQM on various internal advisory boards, companywide initiatives and/or leadership teams.
• Promote transparency and communicate R&D achievements through publications in appropriate scientific journals.

Basic Qualifications

• PhD, MD or PharmD with experience in mechanistic modelling and simulation and systems biology with applications in pharmaceutical research and development.
• Minimum 5 years of experience in mechanistic mathematical modeling, inverse problem modeling and simulation, and/or scientific machine learning methodologies to be applied to pre‑clinical and/or clinical questions in drug development to solve practical problems in the pharmaceutical industry.
• Experience working with senior stakeholders in a cross‑functional environment.
• Track record of implementation of Model‑Informed Drug Discovery and Development (MIDD) approaches to accelerate patient access to novel therapies and to expand therapeutic indications of marketed drugs.

Preferred Qualifications

• Strong drive and agility to quickly learn and build knowledge on a drug‑disease system, the mechanism, endpoints, progression, prevention, treatments, and trial design.
• Demonstrated aptitude for productive collaboration in a multi‑discipline team, using effective communication and taking personal accountability for timely delivery of results.
• Clear evidence or experience in making sound judgement in complex situations and adapting to changing business needs by prioritizing multiple tasks.
• Prior experience in Hepatology and/or Cardiometabolic diseases is a plus.

Compensation and Benefits

If you are based in Cambridge, MA; Waltham, MA; Rockville, MD; or San Francisco, CA, the annual base salary for new hires in this position ranges from $188,100 to $313,500. The US salary ranges incorporate factors such as work location, skills, experience, education level and market rate. This position offers an annual bonus and eligibility to participate in a share‑based long‑term incentive program. Available benefits include health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave.

Equal Opportunity Employer

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

Accommodation Information

If you require an accommodation or other assistance to apply for a job at GSK, please contact the appropriate Recruitment Staff by emailing us at usrecruitment.adjustments@gsk.com.