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- Tasks: Lead DMPK studies to support innovative drug development and make a real impact on patient lives.
- Company: Grünthal Group, a leader in pain research and development.
- Benefits: Permanent position with hybrid work, competitive salary, and opportunities for professional growth.
- Why this job: Join a passionate team at the forefront of drug discovery and help change lives.
- Qualifications: Degree or PhD in biological sciences with experience in DMPK and drug development.
- Other info: Dynamic environment with exciting innovation in small molecules and genetic medicines.
The predicted salary is between 48000 - 72000 £ per year.
In Research & Development, we’re continuously exploring innovative new treatment options to make a stronger, more positive impact on the lives of the patients we serve. You’ll work with talented colleagues in a state‑of‑the‑art Research & Development environment, developing innovative medicines that change the life of patients for the better and help us make progress towards our vision of a world free of pain.
What The Job Looks Like
- DMPK representative on project teams influencing project progression from target validation through to candidate selection and into preclinical development.
- For small molecule and oligonucleotide projects, lead the scientific and operational design, conduct, implementation, and analysis of DMPK, ADME and PKPD studies to support the progression of discovery projects towards candidate selection and preclinical development using state‑of‑the‑art computational, in vitro and in vivo technologies.
- Align with Medicinal Chemistry, Pharmacology, Genetic Medicines, Pharmaceutical Sciences and Clinical to ensure human PK, PKPD and dose predictions are undertaken to aid project decision making from target validation through to candidate selection for all modalities.
- Align with non‑clinical safety to integrate PK and metabolism understanding into safety risk assessment, interpretation and quantitation/prediction of therapeutic margin of candidate molecules.
- Engage with Development DMPK and Clinicians to ensure human PK, PKPD, ADME and DDI predictions of candidate molecules are sufficiently robust to be utilised effectively in early clinical study design and dose selection.
- Engage with CROs and external consultants regarding conduct and interpretation of both discovery and preclinical development DMPK studies.
- Keep abreast of DMPK science through literature and conferences and look to publish work where possible.
What You’ll Bring To The Table
- Educated to degree or PhD level in biological or pharmacological sciences or related field with at least several years experience gained working in DMPK discipline in industry as a DMPK project representative on discovery and development projects.
- For small molecules, expert technical knowledge of ADME/DMPK principles particularly in drug discovery and good understanding of their relationship to drug design, pharmacology and PKPD.
- For oligonucleotides, sound understanding of DMPK and PKPD principles for these modalities and preferably some experience of oligonucleotide projects.
- Ability to design, initiate and oversee discovery DMPK/ADME studies at CROs with timely delivery of data and interpretation that drives DMPK optimisation.
- Track record of interpretation and reporting of DMPK studies to support decision making.
- Experienced in pharmacokinetic analysis with experience in use of software such as Phoenix/WinNonLin PK.
- Excellent written and communication skills.
- Demonstrated ability to work in a matrix environment, multi‑task, meet deadlines and deal with evolving priorities.
DMPK sciences plays a crucial role at the interface between preclinical and clinical development. At Grünthal we are at an exciting phase of innovation of small molecules and genetic medicines for Pain R&D. Come join us in DMPK on this journey.
Discovery DMPK Lead (m/f/d) in Maidenhead employer: Grünenthal Group
Contact Detail:
Grünenthal Group Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Discovery DMPK Lead (m/f/d) in Maidenhead
✨Tip Number 1
Network like a pro! Reach out to professionals in the DMPK field on LinkedIn or at industry events. A friendly chat can open doors that a CV just can't.
✨Tip Number 2
Prepare for interviews by diving deep into the latest DMPK research and trends. Show us you’re not just knowledgeable but passionate about making a difference in drug discovery!
✨Tip Number 3
Practice your pitch! Be ready to explain how your experience aligns with our mission at Grünthal. We want to hear how you can contribute to our innovative projects.
✨Tip Number 4
Don’t forget to apply through our website! It’s the best way to ensure your application gets the attention it deserves. Plus, we love seeing candidates who take that extra step.
We think you need these skills to ace Discovery DMPK Lead (m/f/d) in Maidenhead
Some tips for your application 🫡
Tailor Your CV: Make sure your CV is tailored to the Discovery DMPK Lead role. Highlight your experience in DMPK, ADME, and PKPD studies, and don’t forget to mention any relevant projects you've worked on. We want to see how your background aligns with what we’re looking for!
Craft a Compelling Cover Letter: Your cover letter is your chance to shine! Use it to explain why you’re passionate about DMPK and how your skills can contribute to our mission at Grünthal. Keep it engaging and personal – we love to see your personality come through!
Showcase Your Achievements: When detailing your experience, focus on specific achievements rather than just listing duties. Did you lead a successful project? Did your work improve processes? We want to know how you made an impact in your previous roles!
Apply Through Our Website: We encourage you to apply directly through our website. It’s the best way to ensure your application gets into the right hands. Plus, you’ll find all the details you need about the role and our company culture there!
How to prepare for a job interview at Grünenthal Group
✨Know Your DMPK Inside Out
Make sure you brush up on your knowledge of DMPK principles, especially in relation to drug discovery. Be prepared to discuss how your expertise can influence project progression and decision-making in the context of both small molecules and oligonucleotides.
✨Showcase Your Collaborative Spirit
This role requires working closely with various teams like Medicinal Chemistry and Pharmacology. Highlight your experience in a matrix environment and be ready to share examples of how you've successfully collaborated across disciplines to drive projects forward.
✨Demonstrate Your Analytical Skills
Be prepared to talk about your experience with pharmacokinetic analysis and the software tools you’ve used, such as Phoenix or WinNonLin PK. Bring specific examples of how your analytical skills have contributed to successful DMPK studies and decision-making.
✨Stay Current and Curious
Show your passion for DMPK science by discussing recent literature or conferences you've attended. This demonstrates your commitment to staying updated in the field and your eagerness to contribute to innovative research at Grünthal.
