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- Tasks: Lead in vivo pharmacology for oncology drug discovery and execute tumour model studies.
- Company: GSK is a global biopharma company focused on advancing health through innovative science and technology.
- Benefits: Enjoy comprehensive benefits, including wellness programmes and opportunities for personal growth.
- Why this job: Join a passionate team making a real impact in cancer research and drug development.
- Qualifications: PhD or extensive experience in life sciences with expertise in in vivo oncology models required.
- Other info: Position based in Cambridge, MA, with a commitment to diversity and inclusion.
The predicted salary is between 48000 - 72000 £ per year.
The Oncology Intracellular Targeted Cancer Therapeutics Unit has an opening for an In Vivo Principal Scientist at its Cambridge, MA site. The successful candidate will work together with a highly motivated team to discover and develop novel oncology drugs with a clear genetic relationship to cancer. The primary responsibility of this position will be to represent in vivo pharmacology in various project teams and lead the in vivo strategy to move the program forward. The candidate should be able to independently execute on a variety of in vivo techniques used to evaluate a compound in mouse tumor models and deliver high quality data. The candidate must be proficient in planning, executing and analyzing data to effectively achieve project goals and timelines.
Responsibilities:
- To be the in vivo lead for early-stage discovery programs and be responsible for generating in vivo proof of concept data for anti-tumor efficacy in genetically relevant tumor models.
- Work with the project team to generate efficacy-PK-PD correlation for the lead compound.
- Share data with the project team and at other internal or external forums.
- Responsible for end-to-end execution of the in vivo tumor model studies including, in life portion, data analysis and recording.
- Works in compliance with GSK’s institutional animal welfare guidelines for the use of animals in research.
- Writing study reports for regulatory submissions.
Basic Qualifications:
- Doctorate / PhD in Cell Biology, Molecular Biology, Biochemistry, Pharmacology, or related life sciences field with 2+ years of pharmaceutical or biotechnology In Vivo Oncology Industry experience.
- Non-PhD in Cell Biology, Molecular Biology, Biochemistry, Pharmacology, or related life sciences field with 10+ years of pharmaceutical or biotechnology industry experience in in vivo oncology.
- 2+ years of experience designing, conducting, and analyzing data from in vivo tumor model studies for oncology.
- Experience in working with vivo tumor models (CDX - Cell line derived, PDX - Patient derived and Syngeneic mouse models).
- Experience in techniques including cell culture, compound preparation and formulation, administration to mice (i.v., s.c., p.o.), tumor implantation and measurements.
- Experience managing multiple priorities in a matrix environment.
Preferred Qualifications:
- Knowledge of translationally relevant tumor models in both solid and haem tumor space.
- Demonstrated expertise including PK/PD, efficacy and biomarker studies to inform patient selection strategies, dose and schedule optimization, and identify rationale drug combinations.
- Data analytical skills using Prism Graph Pad or other software.
- Ability to lead from the bench in problem solving and the development of innovative solutions.
- Excellent communication and presentation skills.
- A proven track record of high productivity and scientific publications in peer-reviewed journals.
- Excellent record-keeping and organization skills.
The position is available in Cambridge, MA, USA.
Principal Scientist, In Vivo Tumor Model Oncology Drug Discovery employer: GlaxoSmithKline
Contact Detail:
GlaxoSmithKline Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Principal Scientist, In Vivo Tumor Model Oncology Drug Discovery
✨Tip Number 1
Make sure to highlight your hands-on experience with in vivo techniques during networking events or informal meet-ups. Engaging with professionals in the oncology field can help you gain insights and potentially get referrals.
✨Tip Number 2
Attend relevant conferences or workshops focused on oncology drug discovery. This not only enhances your knowledge but also allows you to connect with key players in the industry who might be involved in hiring decisions.
✨Tip Number 3
Join online forums or groups related to in vivo pharmacology and oncology research. Engaging in discussions can help you stay updated on industry trends and may lead to job opportunities through connections made in these communities.
✨Tip Number 4
Consider reaching out directly to current employees at StudySmarter or GSK via LinkedIn. Expressing your interest in the Principal Scientist role and asking for informational interviews can provide valuable insights and possibly a foot in the door.
We think you need these skills to ace Principal Scientist, In Vivo Tumor Model Oncology Drug Discovery
Some tips for your application 🫡
Tailor Your CV: Make sure your CV highlights relevant experience in in vivo oncology and any specific techniques mentioned in the job description, such as working with CDX, PDX, and syngeneic mouse models.
Craft a Compelling Cover Letter: In your cover letter, express your passion for oncology drug discovery and detail how your background aligns with the responsibilities of the Principal Scientist role. Mention specific projects or achievements that demonstrate your expertise.
Highlight Data Analysis Skills: Since data analysis is crucial for this role, emphasise your proficiency with software like Prism Graph Pad. Provide examples of how you've used data to inform project decisions in previous roles.
Showcase Communication Skills: Given the importance of sharing data with project teams and presenting findings, include examples of your communication skills. Mention any presentations or publications that showcase your ability to convey complex information effectively.
How to prepare for a job interview at GlaxoSmithKline
✨Showcase Your In Vivo Expertise
Be prepared to discuss your experience with in vivo techniques, particularly in mouse tumor models. Highlight specific projects where you successfully executed these techniques and the impact they had on drug discovery.
✨Demonstrate Data Analysis Skills
Since data analysis is crucial for this role, be ready to explain your approach to analysing in vivo data. Familiarise yourself with tools like Prism Graph Pad and be prepared to discuss how you've used them in past projects.
✨Communicate Clearly
Effective communication is key in a collaborative environment. Practice articulating complex scientific concepts clearly and concisely, as you'll need to share findings with both internal teams and external forums.
✨Prepare for Problem-Solving Scenarios
Expect questions that assess your problem-solving abilities. Think of examples where you led from the bench to overcome challenges in your research, and be ready to discuss innovative solutions you developed.
